Latest Articles in Sepsis

  • Immune dysfunction in sepsis

    An overview of the recent advances in the diagnosis and treatment of immune system dysfunction in sepsis. Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection (Singer et al. 2016). Sepsis-induced immune system dysfunction is an important sequelae of sepsis. The persistence of immune system dysfunction...

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  • Sepsis code implementation at Vall d’Hebron University Hospital: rapid diagnostics key to success

    Implementation of a sepsis code, Código Sepsis, in October 2015 at the Vall d’Hebron University Hospital in Barcelona has led to better detection and a significant reduction in mortality. The hospital is the largest in Barcelona, with more than 1,100 beds and 7,000 employees. The objectives of Código Sepsis are to increase suspicion of sepsis and...

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  • Reducing avoidable harm and death from sepsis and acute kidney injury

    Achieving large-scale behaviour change with the NHS Wales programme In 2016 NHS Wales received the Global Sepsis Award, recognising the work throughout the healthcare system on improving identification and treatment of sepsis, which has coincided with an apparent reduction in mortality and ICU admissions for patients with two International...

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  • Improving sepsis outcomes in Brazil

    Flávia Machado is Professor of Intensive Care and Head of the Intensive Care Section of the Anesthesiology, Pain and Intensive Care Department at the Federal University of São Paulo in São Paulo, Brazil. She is one of the founders of the Latin America Sepsis Institute (LASI), which is devoted to quality improvement process in Brazilian hospitals as...

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  • The hidden faces of sepsis, what do they tell us? Focal points for improving patient outcome

    Based on the patients’ perspective Nutma sheds light on the hidden faces of sepsis, calling for more expertise on sepsis sequelae. She also offers recommendations to improve recovery and outcome.   It wasn’t until 2007, after my illness that: “I came to understand the extensive process of recovery after critical illness. Moreover, I came to...

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  • Sepsis Detection and Management: New KLAS Report

    Healthcare providers are increasingly turning to technology to detect sepsis and report on sepsis management. As most electronic medical record (EMR) providers do not offer easily deployed sepsis modules, healthcare providers report using solutions from infection control and surveillance vendors as well as specialised sepsis solutions. KLAS Research’s...

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  • Surviving Sepsis Campaign 2016 Guidelines Released

    The Surviving Sepsis Campaign (SSC) ( survivingsepsis.org ), has released its 2016 guidelines for the management of sepsis and septic shock. The document, published simultaneously in Critical Care Medicine and Intensive Care Medicine , is an update to the 2012 SSC guidelines. The recommendations in the document cannot replace the clinician’s...

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  • Precision Medicine in Sepsis

    Multiple failed clinical trials testing immunomodulatory therapies for sepsis argue for a new approach. While precision medicine has been successfully implemented in other fields, testing it in sepsis poses challenges, which this review will discuss, along with potential implementation strategies. Sepsis has an estimated annual incidence of 1.3...

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  • Albumin Administration in Sepsis: The Case for and Against

    Serum albumin is an essential plasma protein, with a variety of homeostatic and predictive roles in health and disease (Figure 1) . Hypoalbuminaemia is common in critical illness. Human albumin solution has been administered clinically for more than five decades, but its use has been subject to marked controversy for the last twenty years (Fanali...

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  • Vasoactive Drugs in Sepsis

    In this update review on vasoactive drugs in sepsis, we focus on the ‏most recent data regarding the type of vasopressors that should be ‏used, the timing of infusion, the mean arterial pressure target and ‏the alternative approaches.   Sepsis and especially septic shock is associated ‏with arterial vasodilation refractory to ‏fluid challenge. The...

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