Fluid and Vasopressor Decisions in Early...
- Sepsis
- 30/04/2024
Latest Articles in Sepsis
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New hospital policies and procedures required for patient safety
Eighteen Actionable Patient Safety Solutions are the key to zero preventable patient deaths in our hospitals. What are the patient safety processes that every hospital administrator and healthcare professional should adopt today to avoid preventable patient harm and death in hospitals? It’s an unfortunate fact of the medical profession...
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Extravascular lung water as a target for intensive care
The paper highlights the present clinical rationale for extravascular lung water measurement as a key to personalisation of haemodynamic therapy. Introduction Extravascular lung water (EVLW) remains a useful guide for monitoring pulmonary oedema (PO) and vascular permeability in sepsis, acute respiratory distress syndrome (ARDS),...
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Shock
Shock is an emergency, and if it is not treated, it will mostly be fatal. Early intervention and admission to the ICU is essential. Our cover story considers several aspects of shock, including pathophysiology and multi-organ dysfunction syndrome, as well as source control, fluids, differentiation using point-of-care ultrasound and vasoactive medication....
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Pathophysiology of endotoxic shock
Mechanisms of endotoxin-induced multi-organ damage. Endotoxin-induced sepsis remains a leading cause of mortality in intensive care units (ICUs) worldwide. Lipopolysaccharide (LPS) identification by the immune system triggers a cascade of signalling pathways, leading to the release of several cytokines and chemokines, which orchestrate the...
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Advances in source control in patients with sepsis and septic shock
In the past decades there have been significant advances in the diagnosis and management of patients with sepsis and septic shock, and overall awareness has increased significantly (Angus and van der Poll 2013). Emphasis is currently on the early detection of sepsis and rapid initiation of fluid administration and antibiotic therapy, all of which...
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What’s new in sepsis in children?
The latest in diagnosis and treatment. Sepsis is a life-threatening condition in children. Current paediatric definitions are based on systemic inflammatory response syndrome. Since the publication of the third international consensus definitions for sepsis and septic shock for adults, efforts in paediatrics are focused on finding a definition...
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The sepsis box, bag and trolley
Evaluation of aids to the delivery of sepsis treatment. In NHS Wales the Sepsis 6 bundle, delivered within one hour of sepsis recognition, has been standard treatment in acute hospital settings since 2013. We describe various methods for increasing the speed and effectiveness of Sepsis 6 bundle delivery that have been trialled with positive...
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The Accelerate Pheno™ system in clinical practice: fast and accurate turnaround for critical results
Our clinical experiences of using the Accelerate Pheno™ system have greatly benefited patient care, providing earlier diagnostic certainty. Two complex sepsis cases are discussed, where the impact of rapid identification, with antibiotic sensitivities, of the causative organism from blood cultures is described. At Hampshire Hospitals NHS...
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Improving diagnostic stewardship by using new microbiological technologies
Describes an episode of sepsis in a leukaemia patient, whose treatment was early guided by using rapid diagnostics technology to identify the cause of infection. A 4-year-old patient under treatment for acute lymphoblastic leukaemia, diagnosed 6 months before, was admitted to the emergency room (ER) at midnight (00h33) due to a fever episode...
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Gut microbes protect against sepsis
New research published in Cell Host & Microbe suggests that gut bacteria may help in the fight against sepsis. In the study, mice were given particular microbes, which increased blood levels of immunoglobulin A (IgA) antibodies, protecting the mice against polymicrobial sepsis. You might also like : Study: Microbiome Disruption May Have Key Role...
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Latest News
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Unravelling the Role of HIF-1α in Sepsis
- Sepsis
- 02/04/2024
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Vascular Leak in Sepsis
- Sepsis
- 26/03/2024
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