Sepsis remains a leading cause of mortality and long-term disability in intensive care, with outcomes varying widely across hospitals despite advances in technology and repeated guideline u
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The TARTARE-2S trial investigated whether a haemodynamic strategy focused on improving tissue perfusion while permitting lower-than-recommended mean arterial pressure (MAP) could improve outcome1
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Current approaches to classifying sepsis are limited because they rely too heavily on clinical features and host-only immune responses, while largely ignoring the role of the infecting microbes.1
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Sepsis is a critical medical emergency that requires prompt treatment with broad-spectrum antibiotics (BSAs) to cover potential multidrug-resistant organisms (MDROs). While early empiric BSA the1
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Sepsis is a life-threatening condition caused by a dysregulated immune response to infection. Many immunotherapy trials have failed because sepsis presents with highly variable immune states, ra1
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Sepsis remains a major cause of in-hospital mortality worldwide and places a substantial burden on intensive care units and healthcare systems. Despite regular updates to clinical guidance
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Hospitals depend on round-the-clock nursing teams to monitor patients, deliver treatment and coordinate care. When planned staffing falls short, the impact can be immedi
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Sepsis remains one of the leading causes of death in intensive care units worldwide. Despite significant progress in early detection and management, antibiotic dosing protocols often f
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The European Society of Intensive Care Medicine (ESICM) convened an international panel of experts to develop evidence-based guidelines on fluid resuscitation volumes for adult critically ill pa1
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Sepsis remains the leading cause of death in burn care, yet early recognition is complicated by persistent hyperinflammatory responses and altered baseline physiology following ma
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