A recent study investigates the clinical factors influencing clinician decisions regarding fluid administration, vasopressor initiation, and vasopressor route in early sepsis. Previous conce
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A recent review explores the crucial role of hypoxia-inducible factor-1α (HIF-1α) in the development and progression of sepsis. Hypoxia-inducible factor (HIF) is a protein complex consistin
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Sepsis remains a major cause of mortality, accounting for nearly 20% of global deaths. Microcirculatory dysfunction, marked by irregular blood flow and increased permeability of blood vessel
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Findings presented at #ISICEM24 show that novel host transcriptomic signatures specific for bacterial and viral infection in children evaluated for sepsis can identify dysregulated host response...
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Sepsis is characterised by dysregulated immune responses. Traditional approaches to treating sepsis by targeting proinflammatory and immunosuppressive responses have been largely unsuccessfu
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Early recognition and initiation of antibiotics are crucial in managing sepsis. Various warning scores, including qSOFA (quick Sequential Organ Failure Assessment), have been introduced to a
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In a subgroup analysis of the Activated Protein C and Corticosteroids for Human Septic Shock (APROCCHSS) trial, researchers aimed to explore the effects of hydrocortisone plus fludrocortiso
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Nearly 1.7 million adults in the United States contract sepsis annually, with approximately 350,000 succumbing to the condition. In a recent study published in npj Digital Medicin
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Sepsis, characterised by severe organ dysfunction, is a major cause of hospitalisation and mortality globally. The WHO recognises sepsis as a significant global health concern, urging efforts to...
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In 2017, an estimated 25 million children worldwide experienced sepsis, resulting in over 3 million deaths. Paediatric sepsis survivors often face ongoing physical, cognitive, emotional, and psycholo
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