Latest Articles in Sepsis

  • Sepsis in Critical Care: Effective Antimicrobial Strategies in ICU

    ICU sepsis is associated with a mortality rate >25%, with nosocomial infection most lethal, and community acquired infection more common. Optimal management requires identification of the site of infection (lung, abdomen and blood stream most commonly), a focus on the likely pathogens based on risk factors for resistance, and provision of timely and...

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  • The Alphabet Book of Sepsis

    In this article, the author provides the alphabet review of sepsis and septic shock based on personal clinical experience and choice. Sepsis and septic shock have been defined in 2016 (Singer et al. 2016) and the management of patients is framed by the Surviving Sepsis Campaign guidelines with its renewed version in 2021 (Evans et al. 2021)....

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  • Sepsis Surveillance (Sepsis Sniffer): Where We Are Now and Where We Are Going

    Timely recognition of sepsis is the foundation of improved patient survival. This article discusses opportunities to improve this in multiple areas and the use of sepsis screening tools to improve surveillance and treatment of sepsis. Sepsis is a critical healthcare problem, associated with high mortality rates, and considerable financial...

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  • Symmetrical Peripheral Gangrene

    In this article, the authors describe the presentation, pathophysiology, and potential treatment options for symmetrical peripheral gangrene. Limitations in the current literature and a possible strategy for future study are highlighted. Introduction Symmetrical peripheral gangrene (SPG) refers to the development of tissue necrosis in...

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  • Sepsis in Critical Care

    Sepsis is a leading cause of admission to the ICU and is associated with a high mortality rate. Join our panellists as they discuss the impact of sepsis in critical care, characteristics of patients with sepsis, causative factors, and effective preventive and therapeutic interventions. Moderator Jean-Louis Vincent  Editor-in-Chief ICU Management...

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  • Microbiome in Sepsis and COVID-19

    Bacteria play a fundamental role in human life. Given the many roles of gut microbiota in critical illness and other pathological conditions, it is important to target therapeutical interventions to restore, preserve and enrich its composition. Introduction Bacteria play, for better or worse, a fundamental role in human life. As...

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  • The Challenge of Admitting a Very Old Patient with Sepsis to an Intensive Care Unit

    Sepsis incidence in very old patients is high and related mortality and morbidity are a major health concern. Frailty and severity of illness, not just age or sepsis diagnosis, are the determinant factors in outcome. Early identification and treatment are decisive in their survival. N owadays, we are facing some important facts: there has...

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  • Twenty Lessons from 2020: With a Focus on the ICU Perspective

    2020 has been an unusual year. As we begin 2021, it is important for intensivists to look back over what has happened and see whether lessons can be learned from our combined experiences . T he year 2020 has been unusual in so many ways and as we start a new year, it is interesting and important as intensivists to look back and reflect on what...

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  • Promising Techniques in Sepsis After Cardiac Surgery

    The purpose of this article is to give an up-to-date, comprehensive review on the utilisation of extracorporeal blood purification techniques and immunostimulation in septic patients after cardiac surgery. Introduction Sepsis is a potentially life-threatening state caused by an infection and an inadequate, dysregulated host immune...

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  • Advances in Sepsis Research – New Tools Against One of the Oldest Diseases?

    Sepsis and septic shock are the leading causes of death in the ICU. With an estimated mortality rate of 40-60%, septic shock is in the focus of adult critical care medicine. It is broadly accepted that intervention in the very early phase of sepsis before the complex inflammatory host response is initiated should be one major area that clinical research...

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