New Imaging Tool Could Make Brain Tumour Removal Safer
"As a neurosurgeon, I'm in agony when I'm taking out a tumour. If I take out too little, the cancer could come back; too much, and the patient can be permanently disabled," says Alfredo Quinones-Hinojosa, MD, a professor of neurosurgery, neuroscience and oncology at the Johns Hopkins University School of Medicine and the clinical leader of the research team. "We think optical coherence tomography has strong potential for helping surgeons know exactly where to cut."
First developed in the early 1990s for imaging the retina, OCT operates on the same echolocation principle used by bats and ultrasound scanners, but it uses light rather than sound waves, producing a higher-resolution image than does ultrasound. Also, OCT delivers no ionising radiation to patients.
The Johns Hopkins team thought OCT might provide a solution to the problem of separating brain cancers from other tissue during surgery. They first built on the idea that cancers tend to be relatively dense, which affects how they scatter and reflect lightwaves. The team tried for three years to build their technique on this principle. Eventually, the researchers figured out that a second special property of brain cancer cells — that they lack the so-called myelin sheaths that coat healthy brain cells — had a greater effect on the OCT readings than did density.
Once they had found the characteristic OCT "signature" of brain cancer, the Johns Hopkins team devised a computer algorithm to process OCT data and, nearly instantaneously, generate a colour-coded map with cancer in red and healthy tissue in green (see accompanying image). "We envision that the OCT would be aimed at the area being operated on, and the surgeon could look at a screen to get a continuously updated picture of where the cancer is — and isn't," explains Xingde Li, PhD, a professor of biomedical engineering at Johns Hopkins and an author of the study.
The team has already tested the system on fresh human brain tissue removed during surgeries and in surgeries to remove brain tumours from mice. The researchers hope to begin clinical trials in patients this summer.
The system can potentially be adapted to detect cancers in other parts of the body, according to Carmen Kut, an MD/PhD student at Johns Hopkins and also co-author of the study. She is working on combining OCT with a different imaging technique that would detect blood vessels to help surgeons avoid cutting them.
Source: Johns Hopkins Medicine
Image credit: Carmen Kut, Jordina Rincon-Torroella, Xingde Li and Alfredo Quinones-Hinojosa/Johns Hopkins Medicine
Published on : Fri, 19 Jun 2015
Print as PDF
The SonoSite X-Porte is a high resolution, all digital ultrasound kiosk designed to meet the needs of the demanding clinical environment. The X-Porte Kiosk includes: a capacitive multi-touch panel user interface, adjustable high resolution 19” LED monitor...
Mobile Excellence Featuring advanced imaging technology incorporated in compact hardware, the HM70A with Plus is the right choice for physicians and sonographers who want to deliver excellence in patient care and clinical efficiency wherever they go...
Daily Inspiration The HS70A was designed for hospital and private care - with you - the user in mind. The HS70A can be used in Radiology. Internal Medicine, Vascular Surgery. Urology. Gynecology. Pediatrics, Preventive medicine, Orthopedics, Physiotherapy...
The iViz is a lightweight Point Of Care (POC) ultrasound solution, specifically designed for emerging sub-segments where there is need for a highly accessible and mobile solution that is capable throughout key areas of the patient care path. The iViz...
Wide high-resolution touch screen for easy ECG review Full-size keyboard with a durable cover keeping dust, dirt and liquids away, making it highly hygienic ETM Sport, the first automated interpretation of athletes’ ECGs based on the Seattle...