MRI Contrast Agents: Study Highlights 'Safety Issue'
The findings could have a major impact on the multimillion-dollar market for MRI contrast agents, according to Investigative Radiology Editor-in-Chief Val M. Runge, MD, of University Hospital Zurich. He comments, “This important safety issue may lead to certain linear GBCAs not being used in the future.”
Researchers led by Philippe Robert, PhD, of the French pharmaceutical company Guerbet, conducted experiments in rats to evaluate the effects of repeated injections of GBCAs. Three groups of rats were involved in the experiments: over five weeks, one group received a series of 20 injections with gadodiamide (one of a class of agents known as “linear” GBCAs); another group was injected with a different type of GBCA — the “macrocyclic” agent gadoterate meglumine; and a third group received an inactive saline solution.
Over time, “significant and persistent” MRI abnormalities (called T1-weighted signal hyperintensities) developed in the brains of rats receiving the linear GBCA, gadodiamide. There were no MRI abnormalities detected in the brains of rats injected with the macrocyclic agent, gadoterate meglumine.
Notably, the increases in signal hyperintensity persisted even after the injections stopped. In subsequent examinations, high total gadolinium concentrations were measured in the deep brain (cerebellum) of gadodiamide-treated rats, corresponding to the area of the MRI abnormalities.
The findings support previous studies reporting T1 hyperintensities in human patients receiving multiple injections of linear GBCAs for MRI scans. “Certain of these agents lead to heavy-metal deposition in parts of the brain, which is not seen with the macrocyclic GBCAs,” says Dr. Runge, a pioneer in the development of chelated gadolinium as a contrast agent for MRI.
Gadolinium is the element employed as the basis of GBCAs, which have been widely used as MRI contrast agents for nearly three decades — with nearly 30 million doses given each year worldwide. “However, it is also a toxic heavy metal that is not a normal trace element in the body,” Dr. Runge points out.
Macrocyclic GBCAs were originally developed as a safer alternative to linear GBCAs. Based on the new findings, Dr. Runge predicts that certain GBCAs may soon fall out of use. A question raised by physicians is whether any patient, upon seeing these data, would want to be injected with the less stable agents.
Source: Wolters Kluwer Health
Image credit: Flickr.com
Published on : Sun, 28 Jun 2015
We recognize that the best chance any patient has at getting better is a clinician at their bedside with all the right answers and the confidence to act. SonoSite education and training is the industry standard – no other point-of-care ultrasound manufacturer...
The first wireless, handheld breast ultrasound scanner with exceptional image quality Optimized with preset modes for breast, dense breast and interventional procedures that simplify workflow On-demand high-resolution images – 14 MHz, 192 elements, and...
OmniTom ® is ideal for cranial procedures and is designed to deliver the highest quality non-contrast CT, CT angiography and CT perfusion scans. The combination of its rapid scan time, ultra-small footprint and immediate image viewing makes OmniTom...
UltraDrape is an innovative dressing designed for use during Ultrasound-Guided Peripheral Intravenous (UGPIV) that provides dual-action barrier and securement in one.
X-Insight is an insightful solution to envision more. Mindray’s brand-new solution is an excellent transforming of continuous customer insights into clinical needs, combined with evolving cutting-edge ultrasound technologies. As an intimate...