Biomarkers Linked to Kidney Damage, Death in Critically Ill
The findings of the international, multicentre study led by the University of Pittsburgh School of Medicine are published online in the Journal of the American Society of Nephrology.
The two biomarkers are indicators of cell stress and injury, key components in the development of AKI, according to researchers. AKI is a condition that usually affects those in intensive care, and can occur hours to days after serious infections, surgery or taking certain medications.
"We found that not only do these biomarkers predict the development of AKI but, at high levels, they also tell us about long-term prognosis," said senior author John Kellum, MD, a critical care physician at UPMC and director of the Center for Critical Care Nephrology at the University of Pittsburgh. "This should greatly aid clinicians and researchers attempting to address this too-common complication."
For this study, Dr. Kellum's team enrolled 692 critically ill patients at 35 medical centres in Europe and North America. The primary analysis evaluated the outcomes of patients using a biomarker test (NeproCheck) within the first day of arrival into the intensive care unit. The team found strong associations between the biomarker combination and the risk of renal replacement therapy or death.
AKI is largely asymptomatic, lacking warning signs such as pain, shortness of breath or other clinical symptoms, particularly in the early stages when intervention is most beneficial, the research team explained. The incidence of AKI is high amongst critically ill patients, with up to 50 percent developing some degree of AKI during their illness, increasing the risk of death due to kidney failure.
In September 2014, the U.S. Food and Drug Administration (FDA) gave Astute Medical clearance for marketing the NephroCheck test, designed to predict the risk of sudden kidney injury within 12 hours. The FDA's review included two clinical studies evaluating the test's safety and effectiveness. The studies compared the clinical diagnoses of more than 500 critically ill subjects at 23 hospitals to NephroCheck test results. NephroCheck accurately predicted 92 percent of AKI cases in one study and 76 percent in the other, although it also incorrectly gave a positive result in about half of people without AKI, the FDA said.
Source: University of Pittsburgh Schools of the Health Sciences
Image Credit: Pixgood.com
Published on : Mon, 19 Jan 2015
Print as PDF
Medos customized tubing sets have been individually designed, so that all customer requirements, depending on application and need can be realized. Furthermore tubing sets can be refined by rheoparin or x.eed coating.
Get an complete overview of your POCT setup - from one dashboard Your point-of-care-testing setup probably involves many different types of devices from various manufacturers. Radiometer's AQURE point-of-care management system can give you an overview...
Features The SynoVent E5 is the ventilator you need with the interface you want. It does not only include advanced ventilator functionality for patients ranging from infant to adult, but also a modern, easy-to-use interface. The display can be configured...
Monitor vital signs of sensitive patients with reliable, smart and intuitive technology Not available in the US Sensitive patients, like neonates, require comfortable care. With transcutaneous monitoring, you can easily keep track of the oxygenation...
Always in sight, always in mind Features Mindray believes the best way to predict the future is to create it. The revolutionary BeneVision N22/N19 is designed to optimize user experience by satisfying all your clinical demands. With visionary-stimulating...