Search Tag: Biomarkers
2026 29 Apr
Sepsis remains a major cause of morbidity and mortality in intensive care settings, requiring timely identification to support intervention. A recent systematic review published in International Journal of Medical Informatics evaluates machine learning approaches for early detection and prediction of sepsis, focusing on model explainability1Read more
2026 29 Apr
Sepsis remains a major cause of morbidity and mortality in intensive care settings, requiring timely identification to support intervention. A recent systematic review published in International Journal of Medical Informatics evaluates machine learning approaches for early detection and prediction of sepsis, focusing on model explainability1Read more
2026 29 Apr
Sepsis remains a major cause of morbidity and mortality in intensive care settings, requiring timely identification to support intervention. A recent systematic review published in International Journal of Medical Informatics evaluates machine learning approaches for early detection and prediction of sepsis, focusing on model explainability1Read more
2026 29 Apr
Sepsis remains a major cause of morbidity and mortality in intensive care settings, requiring timely identification to support intervention. A recent systematic review published in International Journal of Medical Informatics evaluates machine learning approaches for early detection and prediction of sepsis, focusing on model explainability1Read more
2026 17 Feb
The Sequential Organ Failure Assessment (SOFA) score is a cornerstone tool in intensive care medicine. Rather than serving primarily as a mortality predictor, it was designed to assess and monitor organ dysfunction in critically ill patients. It forms part of the diagnostic framework for sepsis, where an acute increase of two or more SOFA points c1Read more
2025 09 Nov
Large language models (LLMs) are moving into clinical decision support, yet their value for personalised recommendations remains uncertain. A new benchmark focused on longevity interventions examines how different models perform when asked to generate advice based on biomarker profiles. Using synthetic cases that mirror common scenarios in ge1Read more
2025 09 Nov
Large language models (LLMs) are moving into clinical decision support, yet their value for personalised recommendations remains uncertain. A new benchmark focused on longevity interventions examines how different models perform when asked to generate advice based on biomarker profiles. Using synthetic cases that mirror common scenarios in ge1Read more
2025 09 Nov
Large language models (LLMs) are moving into clinical decision support, yet their value for personalised recommendations remains uncertain. A new benchmark focused on longevity interventions examines how different models perform when asked to generate advice based on biomarker profiles. Using synthetic cases that mirror common scenarios in ge1Read more
2025 22 May
Acute Kidney Injury (AKI) in critically ill patients carries high morbidity and mortality, especially when renal replacement therapy (RRT) is needed. Despite interest in using biomarkers to predict the need for RRT, reliable tools remain lacking. Previous studies, including the RUBY trial, explored biomarkers for persistent AKI but not specificall1Read more
2024 09 Aug
Recent publications on triggers, symptoms, biomarkers, treatment and its association with post-COVID Myalgic encephalomyelitis (ME), better known as the Chronic Fatigue Syndrome (CFS) is a neuroimmunological multisystem disease affecting millions of people worldwide. The global prevalence of CFS ranges between 0.4% and 2.5% and is growin1Read more
2024 07 Aug
Blood-based biomarkers can be used in the diagnosis and treatment of many illnesses, including cancer. Biomarkers, in general, are biological molecules found in blood, other body fluids, or tissues that indicate normal or pathological processes or responses to therapeutic interventions. They may include unusual proteins, enzymes, or norm1Read more
2024 22 Jul
The clinical course and outcomes of sepsis vary widely, but early recognition and intervention with fluids, vasoactive agents, and antimicrobials significantly reduce morbidity and mortality. However, beyond supportive care, therapeutic options for sepsis are limited. Many biomarkers are associated with sepsis severity and outcomes, but their1Read more
2024 02 Jul
Parkinson’s Disease (PD) is identified as the world’s fastest-growing neurodegenerative disorder, affecting approximately 10 million individuals globally. The urgency for effective disease-modifying strategies is underscored by significant gaps in understanding the early molecular events of PD and the absence of reliable biomarkers in easily 1Read more
2024 02 Jun
Longer working hours, the expectation of being constantly “on,” and blurred boundaries between work and personal life are causing workplace stress to spill over into home life. This negative spillover adversely affects mental health, family relationships, work productivity, and job satisfaction. This “epidemic” of work-life imbalance raises co1Read more
2024 09 Apr
Traumatic brain injury (TBI) is a major cause of death and disability globally, with outcomes heavily influenced by both the severity of the initial injury and subsequent secondary injury mechanisms. Systemic insults (SIs), such as hypoxaemia and hypotension, can worsen outcomes by exacerbating the cascade of events following the initial damag1Read more
2024 04 Apr
A team of researchers are exploring the possibility of creating a blood test aimed at early Alzheimer's detection. The group from the University of York is exploring the use of light-based technology to identify specific disease-related protein levels in blood samples. Additionally, they are working on a portable device that could offer diagno1Read more
2023 08 Nov
Sepsis is a life-threatening condition caused by a dysregulated host response to infection. Despite progress in understanding its underlying mechanisms, there's no specific successful treatment for sepsis. Precision therapy is needed, and understanding the heterogeneity of sepsis is crucial. Recent methods have attempted to measure sepsis hete1Read more
2023 13 Oct
An overview of ionised serum magnesium as an important biomarker for critically ill patients and how iMg testing is utilised at Mater Intensive Care. Ionised Serum Magnesium - An Important Biomarker Magnesium is the fourth most common cation in the body and the second most abundant intracellular cation, exceeded only by potassi1Read more
2023 13 Oct
Hospital and ICU nosocomial sepsis screening for acutely ill and high-risk patients and daily measurement of PSP to diagnose nosocomial sepsis three to five days before the onset of symptoms. Introduction Sepsis is a major public health threat and is responsible for 11 million deaths per year (Rudd et al. 2020) among 48.9 million c1Read more
2023 02 May
Dr François Ventura, anaesthesiologist and intensive care physician, gave a lecture on the " C urrent research on sepsis biomarkers and early diagnosis" during the 4th World Sepsis Congress, organised by the Global Sepsis Alliance, which took place the 25 th and 26 th April 2023. He discussed the challenges of diagnosing sepsis, which requires1Read more
2023 20 Apr
An overview of promising biomarkers in critical care, characteristics a biomarker should have and how to ensure their usefulness in clinical practice. Introduction Precision medicine is a medical approach that tailors treatments based on individual patient characteristics and their unique response to therapies for a particular 1Read more
2023 13 Mar
Biomarkers are quantifiable indicators of physiological or pathological processes in the body. They can be useful in establishing a diagnosis, assessing disease progression and a patient's condition and guide therapeutic interventions. However, a great deal could still be done to further improve the utilisation of biomarkers in critical care. 1Read more
2023 13 Mar
Despite several biomarkers having been studied for diagnosis and/or prognosis of acute respiratory distress syndrome (ARDS), their extensive use has not been established. Better knowledge of the pathophysiology of ARDS and acute lung injury (ALI) may help develop new biomarkers. Acute respiratory distress syndrome (ARDS) is characterised 1Read more
2023 13 Mar
This article describes the application of existing and emerging biomarkers in the diagnosis and management of sepsis and pneumonia. Introduction: The Need for Biomarkers in Sepsis Sepsis is defined as a dysregulated host response to infection that results in life threatening organ dysfunction. It carries an estimated1Read more
2023 13 Mar
Biomarkers are an area of rapid discovery in critical care medicine today. They have the potential to improve our ability to identify and manage patients at increased risk of organ failure and death. This article provides an overview of biomarkers of infection in the intensive care unit. The heterogeneity of sepsis makes its identification1Read more
2023 13 Mar
A biomarker defines a measurable indicator of a patient's medical situation that can be measured precisely and accurately. Biomarkers provide value for diagnosis, prognosis, early disease detection, risk stratification, suitable treatment (theragnostic), and trial improvement for patients with sepsis or presumed sepsis. Introduction 1Read more
2023 13 Mar
Abstract Sepsis and antimicrobial resistance are two major public health problems . Sepsis is defined as a dysregulated response of the body to a bacterial infection with organ dysfunction . The 2021 Surviving Sepsis Campaign SSC guidelines proposed characterising the infection based on clinical assessment and the dysregulate1Read more