Search Tag: acute kidney injury
2025 01 Oct
Sepsis frequently results in acute kidney injury, prolonging hospital stay and increasing mortality risk. Incidence estimates range from 35–50% in sepsis and rise to 50–70% in intensive care. Early prediction remains difficult because current approaches rely on blood and urine tests that can be costly, variable and not always available in time...Read more
2025 01 Oct
Sepsis frequently results in acute kidney injury, prolonging hospital stay and increasing mortality risk. Incidence estimates range from 35–50% in sepsis and rise to 50–70% in intensive care. Early prediction remains difficult because current approaches rely on blood and urine tests that can be costly, variable and not always available in time...Read more
2025 04 Sep
Sepsis is a life-threatening, dysregulated immune response often leading to hypotension and multisystem organ dysfunction, with acute kidney injury (AKI) being the most common organ failure in critically ill patients. Traditional broad therapies for sepsis have largely failed due to the heterogeneity of the syndrome. Recent approaches focus on identifying...Read more
2025 24 Jul
Traumatic rhabdomyolysis is a clinical and biochemical syndrome frequently encountered in the intensive care unit, characterised by skeletal muscle necrosis and the release of intracellular components such as myoglobin, creatine kinase, and electrolytes into the bloodstream. Trauma-induced muscle injury may result from crush injuries, compartment...Read more
2025 22 May
Acute Kidney Injury (AKI) in critically ill patients carries high morbidity and mortality, especially when renal replacement therapy (RRT) is needed. Despite interest in using biomarkers to predict the need for RRT, reliable tools remain lacking. Previous studies, including the RUBY trial, explored biomarkers for persistent AKI but not specifically...Read more
2025 25 Mar
Mechanical ventilation increases the risk of acute kidney injury (AKI) in critically ill patients, with studies indicating a three-fold higher risk compared to non-ventilated patients. The lung-kidney cross-talk during mechanical ventilation occurs through three primary mechanisms: (1) gas exchange abnormalities (hypoxaemia and hypercapnia) impair...Read more
2025 14 Jan
Acute kidney injury (AKI) often complicates critical illness, with management focusing on supportive care per the Kidney Disease Improving Global Outcomes (KDIGO) guideline due to the lack of specific reversing therapies. Although timely implementation of these guidelines can reduce postoperative moderate and severe AKI, adherence in routine clinical...Read more
2024 23 Jun
Sepsis can progress to multiple organ dysfunction syndrome or multiorgan failure. Globally, sepsis-related deaths are estimated at 11 million annually, representing 19.7% of total deaths, with a global age-standardised death rate of 148.1 per 100,000 people. Despite advancements in treatment, the case fatality rate for sepsis remains high at 30%...Read more
2023 18 Jul
Sepsis is a frequently encountered condition that leads to severe illness and is associated with significant morbidity and mortality. It is commonly accompanied by acute kidney injury (AKI), known as sepsis-associated acute kidney injury (SA-AKI). The relationship between sepsis and AKI has been investigated in prior studies. However, the absence...Read more
2022 20 Jun
Acute kidney injury (AKI) is a serious complication of sepsis. According to data from several clinical studies, AKI can occur in nearly 50% of patients with sepsis and has a mortality rate of approximately 60% at three months. Renal replacement therapy (RRT) is used to treat AKI, but some data show that it exerts only a limited effect in patients...Read more
2021 17 Aug
Acute kidney injury is highly prevalent among severely ill COVID-19 patients. However, there is very limited data on the progression of AKI and long-term outcomes in these patients. In this study, researchers aimed to describe the prevalence and risk factors for the development of acute kidney injury, its clinical course and progression and renal...Read more
2021 01 Jun
Many critical care patients with severe acute kidney injury (AKI), especially those who develop refractory complications, receive renal replacement therapy (RRT). However, when RRT should be initiated for these patients remains unclear. There is a consensus that in patients with urgent or refractory complications, RRT should be started. However, the...Read more
2021 13 Apr
Delaying renal replacement therapy (RRT) in critically ill patients with severe kidney injury and no severe complication is safe and can allow optimisation of the use of medical devices. However, uncertainty still remains regarding the duration for which RRT can be delayed without risk to the patient. In this study, the researchers evaluate a more-delayed...Read more
2021 23 Mar
Early recognition of sepsis is vital for improving patient outcomes. If detected on time, sepsis can be treated with antibiotics and source control, recognition and reversal of shock and organ support. The three most common organ dysfunctions in sepsis are cardiovascular, renal and respiratory. Cardiovascular and respiratory organ dysfunctions are...Read more
2020 27 Oct
In patients admitted to the ICU following surgery, trauma or septic shock, fluid boluses are often used to increase cardiac output and blood pressure. However, clinical evidence shows that excess fluid administration could be detrimental for patients and could lead to increased rates of acute kidney injury (AKI), prolonged days of mechanical ventilation...Read more
2020 11 Oct
Acute kidney injury (AKI) is a global health issue, accounting for approximately two million deaths per year as well as presenting a heavy economic burden on healthcare systems. Hospital-acquired AKI is associated with increased risk of death and prolonged length of hospital stay. There are no effective treatments beyond supportive care for patients...Read more
2020 30 Jun
ABSTRACT This review discusses the importance of continuous, real-time monitoring of urine flow in critical care patients and its potential role in Acute Kidney Injury (AKI) and fluid management in a variety of clinical conditions. Real-time, reliable monitoring of urine flow enables clinicians to detect early signs of kidney injury, and facilitates...Read more
2020 03 Jun
Incidence and risk factors for acute kidney injury (AKI) in COVID-19 patients Recent reports from China, Italy, and the US indicate that there is a 25-37% incidence of AKI among critically ill COVID-19 patients (Singh 2020, Hirsch et al. 2020). In a study of 5449 hospitalized COVID-19 patients, AKI was observed primarily in patients with respiratory...Read more
2019 23 Aug
Acute Kidney Injury (AKI) is a common occurrence for critically ill patients in the ICU, and its early diagnosis has proven to be challenging. The accuracy of the online, machine-learning-based prediction model, AKIpredictor , was analysed for its use in a clinical setting. The study, which took place over five ICUs in Belgium, compared the predictions...Read more
2020 02 Nov
POSTPONED DUE TO COVID-19 HEALTH CONCERNS TO NOV 2-6TH AND CHANGED TO VIRTUAL MEETING Find IRRIV on Social Media Read more
2019 14 Mar
An overview of the acute kidney injury service launched at the Lancashire Teaching Hospitals NHS Foundation Trust The acute kidney injury service at Lancashire Teaching Hospitals NHS Foundation Trust was launched in October 2015. Key stakeholders were identified and included in the service development from the beginning and throughout which...Read more
2019 30 Jan
Acute kidney injury (AKI) is defined as an abrupt loss in renal function and may be caused by a wide variety of clinical conditions. AKI is a frequent complication of hospitalisation and is associated with an increased risk of chronic kidney disease (CKD), end-stage renal disease (ESRD), and mortality. Based on more recent studies, AKI is also...Read more
2018 20 Nov
Results of a phase IIb prospective randomised controlled trial Prevention of Renal Failure by Nitric Oxide in Prolonged Cardiopulmonary Bypass showed that nitric oxide (NO) administered during surgery and for 24 hours afterwards was safe, and postoperatively reduced the incidence of acute kidney injury (AKI), transition to stage 3 chronic kidney...Read more
2018 30 Jan
Most cases of acute kidney injury (AKI) represent a manifestation of a system-wide disease, which should be addressed in all patients with an elevated serum creatinine. "Acute kidney injury should most often be seen not as a primary disease entity but a marker of a potentially serious, underlying systemic disease; the kidney may be just an innocent...Read more