Search Tag: acute kidney injury
Postoperative-kidney-injury-less-likely-in-off-pump-heart-bypass-patients
2014 02 Jun
Patients requiring coronary artery bypass graft (CABG) operations may be less likely to incur acute postoperative kidney injuries when they are not put on a heart-lung machine (off-pump procedure). However, kidney function one year after surgery is not better preserved compared to on-pump patients. These findings are reported in JAMA’s June 4 issue...Read more
Aki-diagnostic-test-gets-fda-marketing-nod
2014 10 Sep
A new laboratory test to gauge severe acute kidney injury (AKI), developed by Astute Medical (San Diego, CA, USA), has been approved for marketing by the US Food and Drug Administration. The manufacturer said its new "NephroCheck" test is intended to be used in critically ill, hospitalised patients. The urine-based test can detect whether a patient...Read more
Esicm-2014-fenoldopam-after-cardiac-surgery-does-not-reduce-need-for-dialysis
2014 29 Sep
According to a study being presented at the European Society of Intensive Care Medicine (ESICM) annual congress in Barcelona, infusion of the antihypertensive agent fenoldopam in patients with acute kidney injury after cardiac surgery does not reduce the need for renal replacement therapy (dialysis) or risk of death at 30 days. The administration of...Read more
Post-operative-intubation-and-acute-kidney-injury
2014 09 Oct
Acute kidney injury (AKI) is a common complication after cardiac surgery and is generally associated with a poor prognosis. It is also an independent mortality factor in cardiac surgical patients. Cardiac surgery is typically performed under general anaesthesia with patients mechanically ventilated in the postoperative period until they have achieved...Read more
Aspirin-use-in-surgery-does-not-reduce-kidney-infection
2014 17 Nov
According to a new study, neither aspirin nor clonidine reduce the risk of acute kidney injury when used in patients undergoing non-cardiac surgery. The study has been published in JAMA and will be presented at the American Society of Nephrology’s Annual Kidney Week meeting. Approximately 10 percent of the 200 million adults undergoing major...Read more
Biomarkers-linked-to-kidney-damage-death-in-critically-ill
2015 19 Jan
Based on results of a new study, high levels of two novel urinary biomarkers early in critical illness correlate with adverse long-term outcomes in patients with acute kidney injury (AKI). The combination of tissue inhibitor metalloproteinase-2 (TIMP-2) and IGF-binding protein-7 (IGFBP7) can identify patients with AKI who are at greater risk of death...Read more
Global-study-65-of-aki-cases-are-community-acquired
2015 16 Mar
The International Society of Nephrology (ISN) has presented the findings of a new global study on acute kidney injury (AKI), seen by experts as a key step forward in their efforts to eliminate preventable deaths from the condition by 2025 ('0by25 Initiative'), at its annual meeting held in Cape Town, South Africa. AKI is a worldwide problem, killing...Read more
Mayo-study-aki-kidneys-can-be-safely-transplanted
2015 07 Apr
New research published in the American Journal of Transplantation indicates that some kidneys affected by Acute Kidney Injury (AKI) may be safely used for transplantation. The revelation that such kidneys might be useful to patients awaiting organ transplantation can help to alleviate the current shortage of kidneys in the US. The single-site study...Read more
Remote-ischaemic-preconditioning-reduces-kidney-injury-after-cardiac-surgery
2015 30 May
According to a study published in JAMA, the use of remote ischaemic preconditioning reduced the rate of kidney injury and the need for dialysis after cardiac surgery in high-risk patients. The study will be presented at the 52nd European Renal Association/European Dialysis and Transplant Association Congress. The procedure is performed to help protect...Read more
Protocol-for-identifying-patients-at-risk-of-aki
2015 08 Nov
A new streamlined approach for early detection and treatment of acute kidney injury (AKI) has reduced mortality rates by 23 percent and hospital length of stay by 13 percent, according to a pilot study presented at ASN Kidney Week 2015 in San Diego. AKI is a common condition that affects 21 percent of hospitalised adults and 33 percent of hospitalised...Read more
Can-rifle-urine-output-criteria-predict-contrast-associated-nephropathy
2016 10 May
A study that assessed the predictive value of the Risk of renal dysfunction, Injury to the kidney, Failure of kidney function, Loss of kidney function and End-stage renal disease (RIFLE) urine output criteria on contrast-induced nephropathy in critically ill patients found its predictive value to be low, which limits its use for assessing the effects...Read more
Biomarkers-for-acute-kidney-injury-1
2016 30 May
Where Are We Now? Acute kidney injury (AKI) has been recognised as a major public health problem. It affects >50% of patients in the Intensive Care Unit (ICU) and is associated with serious short- and long-term complications, premature death and high financial healthcare costs (Mehta et al. 2015; Hoste et al. 2015; Lewington et al. 2013). The consensus...Read more
Early-diagnosis-and-prediction-of-acute-kidney-injury
2016 30 May
penKid – A Dynamic Inflammation-Independent Biomarker Of Kidney (Dys)function Early recognition and close monitoring of acute kidney injury (AKI) is vital in the ICU, given AKI’s high prevalence and effect on length of stay and risk of re-hospitalisation and death (McCullough et al. 2013). As more becomes known about biomarkers, intensivists need...Read more
Elain-trial-for-aki-significant-mortality-reduction-in-early-rrt-group
2016 22 May
Results of the Early vs Late Initiation of Renal Replacement Therapy in Critically Ill Patients With Acute Kidney Injury (ELAIN) Trial found a significant reduction in 90-day all-cause mortality in the early initiation group. The single-centre study, by Alexander Zarbock , MD, of University Hospital Munster, Germany, and colleagues, which is to be...Read more
Acute-kidney-injury-prediction-and-detection-models
2016 24 May
Risk of acute kidney injury (AKI) can be difficult to predict in older adults, due to age-related declines in glomerular filtration rates, which can affect baseline serum creatinine, and because serum creatinine is influenced by muscle mass, nutritional status and volume distribution. A study published in BMC Medical Informatics and Decision Making...Read more
Optimal-timing-of-renal-replacement-therapy-elusive
2016 24 May
A clear answer for the optimal timing of RRT in critical illness remains elusive, say the authors of a systematic review published in Critical Care . They recommend that clinicians refrain from lowering their clinical thresholds for implementing RRT in critical care patients with acute renal injury. Studies on the timing of renal replacement therapy...Read more
Acute-kidney-injury-recommendations-published
2016 20 Jun
French intensive care and nephrology societies have published recommendations for AKI in the perioperative period and in intensive care units (ICUs). The document is published open access concurrently in Anaesthesia Critical Care & Pain Medicine and Annals of Intensive Care . The recommendations were developed by experts from the Société française...Read more
Study-radiocontrast-aki-risk-lower-than-previously-thought
2016 30 Sep
According to a study published in the Journal of the American Society of Nephrology , radiocontrast administration may have a lower risk of kidney damage than previously thought. The findings suggest that the potential benefits of radiocontrast-enhanced imaging are far greater than its hazards, which could have been overestimated by researchers and...Read more
Study-paediatric-aki-diagnosis-not-following-guidelines
2016 01 Nov
A survey of paediatric intensivists in the U.S. has found that around half are not using current guidelines to diagnose acute kidney injury (AKI) in critically ill children, and over 70 percent are using serum creatinine and urine output only. Only one-third refer children with AKI to a kidney specialist after they are discharged. The study is published...Read more
Peritoneal-dialysis-evidence-guidelines-and-controversies
2017 14 Feb
Peritoneal dialysis (PD) may be a feasible, safe, and complementary alternative to haemodialysis not only in the chronic setting, but also in the acute setting, according to a review in the journal Seminars in Nephrology. PD provides an efficient way to correct metabolic, electrolyte, acid-base, and volume disturbances generated by acute kidney injury...Read more
Study-kidney-damage-diagnosis-may-be-inaccurate-for-many
2017 28 Feb
Researchers from Columbia University Medical Center (CUMC) have found that, for many patients, an initial diagnosis of “acute kidney injury” may have been inaccurate. Their finding, published in Journal of the American Society of Nephrology, suggests that the current method of assessing kidney function may be misleading during the initial evaluation...Read more
The-akipredictor-an-online-calculator-to-predict-acute-kidney-injury
2017 16 Mar
Acute kidney injury (AKI), a rapid decline in renal function, is highly prevalent in critically ill patients, and is associated with an increased risk of short- and long-term complications that extend beyond the acute phase (Pickkers et al. 2017). AKI is defined and classified by an increase in serum creatinine or a decline in urine output, both...Read more
Urine-output-monitoring-and-early-aki-detection
2017 29 May
Urine output (UO) is a vital sign for critically ill patients but standards for monitoring and reporting vary widely between ICUs. New research indicates that intensive monitoring of UO was associated with increased detection of moderate to severe acute kidney injury (AKI), reduced incidence of fluid overload and is independently associated with reduced...Read more
Aki-may-indicate-more-serious-systemic-disease
2018 30 Jan
Most cases of acute kidney injury (AKI) represent a manifestation of a system-wide disease, which should be addressed in all patients with an elevated serum creatinine. "Acute kidney injury should most often be seen not as a primary disease entity but a marker of a potentially serious, underlying systemic disease; the kidney may be just an innocent...Read more
Study-nitric-oxide-decreases-renal-failure-after-cardiac-surgery
2018 20 Nov
Results of a phase IIb prospective randomised controlled trial Prevention of Renal Failure by Nitric Oxide in Prolonged Cardiopulmonary Bypass showed that nitric oxide (NO) administered during surgery and for 24 hours afterwards was safe, and postoperatively reduced the incidence of acute kidney injury (AKI), transition to stage 3 chronic kidney...Read more
Aki-long-term-impact-on-mortality-and-renal-function
2019 30 Jan
Acute kidney injury (AKI) is defined as an abrupt loss in renal function and may be caused by a wide variety of clinical conditions. AKI is a frequent complication of hospitalisation and is associated with an increased risk of chronic kidney disease (CKD), end-stage renal disease (ESRD), and mortality. Based on more recent studies, AKI is also...Read more