• The Seraph® 100: Evidence and Perspectives

    An overview of the clinical application and future perspective of the Seraph® 100 haemoperfusion in critically ill patients with sepsis. Background Over the last few decades, sepsis has been spreading worldwide to such an extent that it has been declared global health priority by the World Health Organization (Reinhart et al. 2017)....

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  • Post-Intensive Care Syndrome - Patients and Families Need to Know They are Not Alone

    In this article, we aim to summarise the current management of Post Intensive Care Syndrome (PICS) and Post-Intensive Care Syndrome – Family (PICS-F), understanding the need for continuum assessment and support throughout critical disease. Illustrating PICS People who have been admitted to an Intensive Care Unit report a reduced quality...

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  • Out-of-Hospital Cardiac Arrest - Long-term Outcomes and their Predictors

    Out-of-hospital cardiac arrests (OHCA) are associated with very high rates of mortality and poor cognitive outcome. This paper reviews long-term outcomes post OHCA and the pre-hospitalisation factors that predict them. Introduction Cardiac arrest is among the most common health emergencies worldwide, suffered by over a half million...

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  • Rehabilitation of the Critically Ill: The Role of Allied Health Professionals

    Rehabilitation and recovery following ICU admission aims to improve patient outcomes, optimising function and recovery. Allied health professionals are key members in the multidisciplinary team, positively contributing to the rehabilitation pathway. S urvivorship after admission to intensive care (ICU) has moved beyond mortality. Reducing...

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  • Infographic

    An overview of the Post-Intensive Care Syndrome (PICS) and the challenges faced by critical care patients post-ICU.

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  • PCT-guided Antibiotic Stewardship in COVID-19 Patients

    Professor Michael Mansour is a physician-scientist with a research concentration in immune responses against invading pathogens. He attends on the Clinical Transplant Infectious Diseases and Immunocompromised Host Service at the Massachusetts General Hospital - Division of Infectious Diseases, where he cares for solid and stem cell transplant recipients...

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  • Lessons From the “Very Old Intensive Care Patients” (VIP) Project

    An overview of the VIP project that studies a subgroup of patients  ≥  80 years, the oldest old, since both ICU mortality and morbidity are increased with advanced age. D uring the last 10 years, we have observed an increased interest in research into our oldest intensive care patients. This is brought forward with the expectation...

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  • In Search of a Crystal Ball: Predicting Long-term Outcomes in Critically Ill Older Adults

    Older adults who survive critical illness are at risk of adverse long-term outcomes, including long-term mortality and impairment in physical function, cognitive function, and mental health. In this article, we discuss the evidence behind prediction of these outcomes in older ICU survivors, and review risk factors that should be considered in...

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  • Angiotensin II in Post Cardiopulmonary Bypass Vasoplegia - The Experience So Far

    Post cardiopulmonary bypass vasoplegia is common, and associated with poor outcomes. Traditional management strategies involving escalating doses of catecholamines, vasopressin and adjuncts such as methylene blue and hydroxycobalamin or ascorbic acid have not shown promising results. Since ACE enzyme dysfunction, high serum renin and low endogenous...

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  • Promising Techniques in Sepsis After Cardiac Surgery

    The purpose of this article is to give an up-to-date, comprehensive review on the utilisation of extracorporeal blood purification techniques and immunostimulation in septic patients after cardiac surgery. Introduction Sepsis is a potentially life-threatening state caused by an infection and an inadequate, dysregulated host immune...

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