• Sepsis in Critical Care

    Sepsis is a leading cause of morbidity and mortality in the intensive care unit. Nearly  14 million adults and 2.5 million children  survive sepsis each year worldwide. In addition, sepsis survivors are known to experience poor long-term outcomes and often develop functional limitations thereafter. It is thus evident that the long-term impact...

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  • Septic Shock and Vasopressor Initiation: Why Earlier is Better

    An overview of vasopressor management, current evidence and when to initiate vasopressor therapy for best possible patient outcome. Vasopressor management is a cornerstone in the haemodynamic management of septic shock for reversing hypotension by increasing systemic vascular resistance and improving organ perfusion. The Surviving Sepsis Campaign...

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  • Rationale Behind Practice: Landiolol in Critical Care

    A summary of data regarding the use of landiolol as a potential immunomodulator in septic patients and its effectiveness and safety in the management of new-onset postoperative atrial fibrillation (POAF). Cardiovascular Dysfunction and Sepsis Cardiovascular dysfunction is a common complication of sepsis. Approximately 40 to 50% of patients...

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  • Gastric Residual Volume – Monitoring and Management

    An overview of critical care guidelines for enteral nutrition (EN) and the use of gastric residual volume (GRV)  management and monitoring as an essential component of EN patient care to help prevent complications. Malnutrition in Critically Ill and the Use of Enteral or Parenteral Nutrition Disease-related malnutrition is a common...

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  • One Sepsis Fits All? Are There Different Phenotypes of Sepsis? Diagnostic Approaches and Therapies

    This article presents current research results in relation to an advanced sepsis classification and their implications for new treatment options and research strategies. Introduction Through history, the definiti on and the term sepsis changed. Since Semmelweis and others formulated the thesis that sepsis was caused by a systemic reaction...

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  • Sepsis Surveillance (Sepsis Sniffer): Where We Are Now and Where We Are Going

    Timely recognition of sepsis is the foundation of improved patient survival. This article discusses opportunities to improve this in multiple areas and the use of sepsis screening tools to improve surveillance and treatment of sepsis. Sepsis is a critical healthcare problem, associated with high mortality rates, and considerable financial...

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  • Symmetrical Peripheral Gangrene

    In this article, the authors describe the presentation, pathophysiology, and potential treatment options for symmetrical peripheral gangrene. Limitations in the current literature and a possible strategy for future study are highlighted. Introduction Symmetrical peripheral gangrene (SPG) refers to the development of tissue necrosis in...

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  • ICU Management of the Very Old: The Evidence Base Anno 2022

    This overview explores the publications concerning the very old ICU patients since 2011 and with a focus on publications from the VIP network on elderly COVID-19 patients. Introduction In 2017, an international group of intensivists with a particular interest for geriatric intensive care published a statement paper (Flaatten et al....

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  • Understanding Carbon Dioxide in Resuscitation

    Peri-arrest CO 2  measurement may serve to assess resuscitation efficacy and guide clinical decisions. This paper reviews current knowledge and future research directions for CO 2  measurement and clinical application during CPR. Carbon Dioxide During Normal Heart-Lung Function CO 2  is produced by the mitochondria...

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  • Sepsis in Critical Care

    Sepsis is a leading cause of admission to the ICU and is associated with a high mortality rate. Join our panellists as they discuss the impact of sepsis in critical care, characteristics of patients with sepsis, causative factors, and effective preventive and therapeutic interventions. Moderator Jean-Louis Vincent  Editor-in-Chief ICU Management...

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