Pharmacodynamic and pharmacokinetic principles play a central role in antimicrobial dose-optimisation to combat antimicrobial resistance. In the future, research focused on the integration of preclinical and clinical data is paramount. Antimicrobial Resistance in the ICU The use of antimicrobial drugs in the hospital is very common...
READ MOREThe importance of clearly defining sepsis, improving early recognition strategy, and increasing the understanding of innate and adaptive immune system derangements that facilitate the development of sepsis. The improvement in mortality outcomes of patients with sepsis is attributable to the early recognition of sepsis, better adherence to guidelines,...
READ MOREThe problem of antimicrobial resistance and the use of a clinical decision score and point-of-care testing biomarkers, such as CRP and PSP, to help solve this problem. Introduction Infectious diseases are a public health issue around the world, with bacterial, viral, parasitic, or fungal-related diseases responsible for 26% of mortality...
READ MOREIn patients with obesity, standard, non-weight-based dosing, or weight-based dosing using either ideal body weight or adjusted body weight, is appropriate to limit the risk of overdosing. The prevalence of obesity is increasing worldwide (Schetz et al. 2019). This trend is confirmed in the Intensive Care Unit (ICU) where patients with obesity...
READ MOREA Practical Approach for Intensivists A practical approach to analgesia, sedation and neuromuscular blockade of critically ill patients and a discussion on potential benefits, adverse effects and current professional international recommendations. Introduction Patients hospitalised in the Intensive Care Unit (ICU) are naturally prone to...
READ MOREIn this article, the authors aim to summarise the current management of delirium, emphasising new publications and possible new studies that will shed light on delirium management strategy. Introduction According to an updated nomenclature of delirium after an interdisciplinary panel of experts from ten medical societies (Slooter et al....
READ MOREJUNE 1-3 ERAS 2022 – World Congress Madrid, Spain https://iii.hm/1eh0 4-6 Euroanaesthesia 2022 Milan, Italy https://iii.hm/1eh5 4-7 45th Annual Conference on Shock Toronto, Canada https://iii.hm/1exk 14-16 40th Vicenza Course on AKI&CRRT Vicenza, Italy / Hybrid https://iii.hm/1exl...
READ MOREEffective pain relief is one of the most important priorities in the ICU. Join our panellists as they discuss different aspects of pain management in critically ill patients and the use and effects of analgesia and sedation in the ICU. Moderator Jean-Louis Vincent (MODERATOR) Editor-in-Chief ICU Management & Practice Professor Department...
READ MOREAn overview of the cardiovascular and respiratory effects of sedative agents commonly used in the ICU, emerging concepts of mechanical ventilation induced injury to the respiratory muscles and evolving concepts for sedation monitoring and sedation minimisation to achieve the goal of expeditious liberation from mechanical ventilation. The...
READ MOREAn overview of the main treatment options currently available in paediatric critical care setting. Critically ill paediatric patients often suffer from pain secondary to trauma, complex medical procedures, invasive testing monitoring devices and illness-induced discomfort. Although the gold standard for assessing patient comfort is self-report,...
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