All Articles
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Combined Extracorporeal Lung and Kidney Support in Fluid Overload
During artificial organ support, kidney injury is multifactorial and related to the high severity of patients treated with extracorporeal membrane oxygenation (ECMO). The successful delivery of continuous renal replacement therapy (CRRT) during ECMO requires a clear prescription of the target solute clearance and fluid removal rate based on the cumulative...
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Which Vasopressors and Inotropes to Use in the Intensive Care Unit
Vasopressors and inotropes are frequently used in intensive care units. With a special focus on recent studies, this article summarises the key messages in the management of patients requiring inotropes and vasopressors. Introduction Cardiac output (CO) is a key determinant of oxygen delivery. Low cardiac output syndrome (LCOS) causes...
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Kidney Replacement Therapy in the Intensive Care Unit
Kidney Replacement Therapy is a commonly used therapeutic strategy in the intensive care unit for patients who develop Acute Kidney Injury or who already have a diagnosis of chronic kidney disease. ICU staff should know when to use it and which type is most suitable for the circumstances. Epidemiology and Outcomes of AKI Acute kidney...
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Predictive Analytics for Kidney Support in the ICU
The timing and application of dialysis in the ICU is highly variable contributing to poor outcomes. A clinical decision support system (CDSS) incorporating a dynamic predictive algorithm for organ support could improve outcomes. Background Multiorgan failure (MOF) and acute kidney injury (AKI) are frequently encountered in critically...
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Early Mobilisation in Patients Undergoing Extracorporeal Membrane Oxygenation
Extracorporeal membrane oxygenation is a resource that is accessible in hospitals and intensive care units all over the world. In serious situations, ECMO therapy is intended to provide haemodynamic and/or ventilatory support. Because of this, many people refer to the ECMO patient as "the most critical patient." As a result, there is a very high...
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Heparin-Induced Thrombocytopaenia
Heparin-induced thrombocytopaenia (HIT) is an immune complication of heparin therapy. This review discusses the pathophysiology, incidence, clinical manifestations, diagnostic approach, and management of patients with HIT. Pathophysiology HIT is an immune complication of heparin therapy caused by IgG antibodies to complexes of platelet...
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Detecting Euglycaemic Diabetic Ketoacidosis Associated With SGLT2 Inhibitors
SGLT2 inhibitor associated EDKA is becoming more prevalent due to the increasing use of SGLT2 inhibitors in cardiovascular medicine and type 2 diabetes. Physician awareness and knowledge about the disease and diagnostic tools need to improve for better management. Point of care blood testing for ketones can allow for rapid and accurate diagnosis....
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Biomarkers
Biomarkers are quantifiable indicators of physiological or pathological processes in the body. They can be useful in establishing a diagnosis, assessing disease progression and a patient's condition and guide therapeutic interventions. However, a great deal could still be done to further improve the utilisation of biomarkers in critical care....
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Biomarkers of Infection in the Intensive Care Unit
Biomarkers are an area of rapid discovery in critical care medicine today. They have the potential to improve our ability to identify and manage patients at increased risk of organ failure and death. This article provides an overview of biomarkers of infection in the intensive care unit. The heterogeneity of sepsis makes its identification...
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Biomarkers in Sepsis - Present and Future
A biomarker defines a measurable indicator of a patient's medical situation that can be measured precisely and accurately. Biomarkers provide value for diagnosis, prognosis, early disease detection, risk stratification, suitable treatment (theragnostic), and trial improvement for patients with sepsis or presumed sepsis. Introduction...
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