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Department of Intensive Care Austin Hospital Heidelberg
Australian and New Zealand Intensive Care Research Centre (ANZIC-RC) School of Public Health and Preventive Medicine Monash University
Department of Critical Care Melbourne Medical School University of Melbourne Austin Hospital
Data Analytics Research and Evaluation (DARE) Centre Austin Hospital
Department of Intensive Care Royal Melbourne Hospital
This review explores bedside methods for monitoring respiratory effort in patients undergoing assisted mechanical ventilation. It highlights the risks of lung and diaphragm injury from excessive or insufficient patient effort, reviews invasive and non-invasive pressure-based techniques, and discusses their strengths, limitations, and proposed safety thresholds. The article emphasises integratin1
READ MOREFinding patients before they crash might be the next major opportunity to improve patient safety. This article describes recent advances and perspectives for ward monitoring with wearable sensors and smart algorithms. Hospital wards are dangerous. Indeed, they are where most unexpected deaths occur within institutions. In a UK national audit study, among 23,554 adult in-hospital cardiac1
READ MOREThis article reviews the RRT system concept and provides an update on the current state of such systems, their challenges, their performance, the evidence supporting their usefulness and their evolution. Rapid Response Teams (RRTs) are the key components of Rapid Response Systems. RRT-based rescue systems were developed in response to evidence that many deteriorating hospital patient1
READ MORECardiac arrest (CA) causes ischaemic brain injury and persistent cerebral hypoperfusion and cerebral hypoxia during the early post-resuscitation period. PaCO2 is the major physiological regulator of cerebral blood flow, is a modifiable component of care and mild hypercapnia may lead to improved neurological outcomes for resuscitated CA survivors. In order to evaluate the potential therapeutic ro1
READ MORESerum albumin is an essential plasma protein, with a variety of homeostatic and predictive roles in health and disease (Figure 1) . Hypoalbuminaemia is common in critical illness. Human albumin solution has been administered clinically for more than five decades, but its use has been subject to marked controversy for the last twenty years (Fanali et al. 2012). This has shaped not just day-to-day1
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Rinaldo Bellomo, MBBS, MD, FCICM, FRACP is Professor of Medicine with the University of Melbourne, Honorary Professor of Medicine with Monash University, Honorary Professor of Medicine with the U1
READ MOREThis review explores current definitions of frailty, methods available to diagnose it, and its application to perioperative and critically ill patients. Frailty is increasingly recognised as a potential contributor to patient outcome during an episode of critical illness. However, there is currently no consensus definition or assessment tool. Two main models exist to conceptualise frailty 1
READ MOREThe Case for Liberal Glycaemic Management Background Several large randomised controlled trials (RCTs) have helped provide evidence to guide clinicians’ decisions about blood glucose management in critically ill patients. In two landmark single centre studies, investigators from Leuven reported a reduction in mortality or morbidity with tight glycaemic control (80-110 mg/dl or 4.4-6.1 m1
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