Older Patients Recover More Slowly from Concussion
"Old age has been recognised as an independent predictor of worse outcome from concussion, but most previous studies were performed on younger adults," says the study's lead author, David Yen-Ting Chen, MD, from the Department of Radiology at Shuang-Ho Hospital, Taipei Medical University, in New Taipei City, Taiwan.
Difficulty in working memory is frequently reported in patients after concussion. However, neuropsychological tests, computed tomography (CT) and conventional magnetic resonance imaging (MRI) generally fail to reveal abnormal findings in these patients. For this study, Dr. Chen and colleagues used functional MRI (fMRI) to evaluate the effect of age on working memory performance and functional activation in the brain after MTBI.
The researchers performed fMRI exams on 13 young adults (21-30 years old) and 13 older adults (51-68 years old) with MTBI and 26 age- and gender-matched controls. The first fMRI scan was performed within one month post-injury. A follow-up scan was conducted six weeks after the first exam. The researchers then analysed post-concussion symptoms, neuropsychological test results and working memory activity in both groups.
The analysis revealed that while performing working memory tasks, the young patients with concussion had initial activation that was greater than normal, known as hyperactivation, compared to young controls in the right precuneus and right inferior parietal gyrus of the brain. In contrast, the older patients had hypoactivation (less than normal) compared to older controls in the right precuneus and right inferior frontal gyrus.
In comparing the patients in initial and follow-up study, the young patients had significantly reduced post-concussion symptom score at follow-up than at the time of the initial exam, but no significant change of the post-concussion symptom score was observed in the older patients, who also showed persistent hypoactivation.
"Taken together, these findings provide evidence for differential neural plasticity across different ages, with potential prognostic and therapeutic implications," co-author Ying-Chi Tseng, MD, from Shuang-Ho Hospital, explains. "The results suggest that MTBI might cause a more profound and lasting effect in older patients."
Source and image credit: RSNA
Published on : Tue, 6 Oct 2015
Print as PDF
Sectra PACS is designed for a high production environment with stability and usability in focus. Highlights include functions to speed up oncology workflows such as anatomical linking and support for reviewing complex multiparametric MRI studies such...
The TE7 touch screen ultrasound system is designed to provide superior quality imaging for rapid patient-care decisions. Intuitive gesture controls and efficient focused point-of-care exams minimize the user learning curve, with no need to navigate a...
Sectra provides a complete solution for primary diagnostics in pathology. The solution includes archiving and storage solutions together with high-end review workstations. It allows pathologists to make their diagnoses and reports with higher precision...
The iViz is a lightweight Point Of Care (POC) ultrasound solution, specifically designed for emerging sub-segments where there is need for a highly accessible and mobile solution that is capable throughout key areas of the patient care path. The iViz...