Dissolvable Surgical Clip Could Improve Imaging Results
Most surgical clips currently available are made of titanium, and as many as 30 to 40 clips may be used during a single surgical procedure. They remain inside the patient’s body after the wounds are healed. Retained clips lead to diminished quality of CT (computed tomography) and MRI (magnetic resonance imaging) images around the wound and may cause complications, according to researchers.
The magnesium alloy that is used to create the new clip also contains calcium and zinc to improve its microstructure, ensuring fastening ability and formability — qualities required of materials to make clips.
The clip was developed as a collaboration between the Division of Mechanics and Physics of Materials at the Kobe University Graduate School of Engineering and the Division of Hepato-Biliary-Pancreatic Surgery at the Kobe University Graduate School of Medicine. The researchers evaluated the safety of the clip by conducting an implantation study in a subcutaneous mouse model. They found that very little gas was produced as the clip dissolved and there was no inflammation of the surrounding tissues after one to 12 weeks. These results suggest that the clip is associated with very few adverse effects.
In addition, blood testing showed that levels of magnesium and other substances in the blood were in the normal range after 12 weeks. The volume of the implanted clip was reduced by almost half after 12 weeks. Hence, the clip is likely to dissolve and exit the body within one year, says the research team.
To evaluate the clip's functionality, the researchers used it in a rat model in which the biliary duct, portal vein, hepatic artery, and hepatic vein were occluded with the clip and a partial liver was removed. The rat experienced no problems during a monitoring period of eight weeks, suggesting that the clip functioned properly. Of note, micro CT scanning of the mouse and rat revealed that the quality of images was not degraded and organs can be observed.
Professor Mukai Toshiji (Department of Mechanical Engineering, Graduate School of Engineering), who was involved in developing the surgical clip, expressed his hopes: “We will conduct further in vivo studies and a clinical study within 2 to 3 years. Kobe University works toward the development of new medical devices. We will continue to promote collaboration between the Graduate Schools of Medicine and Engineering.”
Source and image credit: Kobe University
Published on : Tue, 5 May 2015
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