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People Centric Model to Harness User Value: Personal Data Spaces in Transformation of Health & Care
To reap full benefit of ongoing health system transformation, digital health tools and services are urgently needed to equip citizens as patient, informal caregiver or family member. They are the most important, but least supported actors in healthcare, in need of digital health data and services for health management activities at their personal...
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Sepsis in Critical Care
Sepsis is a leading cause of morbidity and mortality in the intensive care unit. Nearly 14 million adults and 2.5 million children survive sepsis each year worldwide. In addition, sepsis survivors are known to experience poor long-term outcomes and often develop functional limitations thereafter. It is thus evident that the long-term impact...
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Septic Shock and Vasopressor Initiation: Why Earlier is Better
An overview of vasopressor management, current evidence and when to initiate vasopressor therapy for best possible patient outcome. Vasopressor management is a cornerstone in the haemodynamic management of septic shock for reversing hypotension by increasing systemic vascular resistance and improving organ perfusion. The Surviving Sepsis Campaign...
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Rationale Behind Practice: Landiolol in Critical Care
A summary of data regarding the use of landiolol as a potential immunomodulator in septic patients and its effectiveness and safety in the management of new-onset postoperative atrial fibrillation (POAF). Cardiovascular Dysfunction and Sepsis Cardiovascular dysfunction is a common complication of sepsis. Approximately 40 to 50% of patients...
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Sepsis in Critical Care: Effective Antimicrobial Strategies in ICU
ICU sepsis is associated with a mortality rate >25%, with nosocomial infection most lethal, and community acquired infection more common. Optimal management requires identification of the site of infection (lung, abdomen and blood stream most commonly), a focus on the likely pathogens based on risk factors for resistance, and provision of timely and...
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Challenges in the Haemodynamic Management of Septic Shock
An overview of the haemodynamic management of patients in septic shock and strategies for detection of haemodynamic changes and appropriate therapeutic action to improve the prognosis of these patients. Introduction Sepsis is one of the main causes of admission to the Intensive Care Unit (ICU). It is defined as a life-threatening organ...
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Sepsis Surveillance (Sepsis Sniffer): Where We Are Now and Where We Are Going
Timely recognition of sepsis is the foundation of improved patient survival. This article discusses opportunities to improve this in multiple areas and the use of sepsis screening tools to improve surveillance and treatment of sepsis. Sepsis is a critical healthcare problem, associated with high mortality rates, and considerable financial...
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Symmetrical Peripheral Gangrene
In this article, the authors describe the presentation, pathophysiology, and potential treatment options for symmetrical peripheral gangrene. Limitations in the current literature and a possible strategy for future study are highlighted. Introduction Symmetrical peripheral gangrene (SPG) refers to the development of tissue necrosis in...
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ICU Management of the Very Old: The Evidence Base Anno 2022
This overview explores the publications concerning the very old ICU patients since 2011 and with a focus on publications from the VIP network on elderly COVID-19 patients. Introduction In 2017, an international group of intensivists with a particular interest for geriatric intensive care published a statement paper (Flaatten et al....
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Understanding Carbon Dioxide in Resuscitation
Peri-arrest CO 2 measurement may serve to assess resuscitation efficacy and guide clinical decisions. This paper reviews current knowledge and future research directions for CO 2 measurement and clinical application during CPR. Carbon Dioxide During Normal Heart-Lung Function CO 2 is produced by the mitochondria...
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