Optimization, standardization and documentation of the fixation step Accurate control of all steps of the pre-analytical process is a pre-requisite for precise, reliable and consistent diagnostic assays. Recent publications have evidenced that standardization and documentation of the all important fixation step will lead to improved I.H.C. assays. Leaving the specimens in a container with formalin overnight at room temperature does not fulfill the requirements for controlled fixation. Each Laboratory faces very specific problems in carrying out the fixation process. For this reason Milestone has developed a complete line of fixation devices (BASIC, PRO, ADVANCED) to allow optimization, standardization and full documentation of this process. All fixation devices accept the racks utilized by major tissue processor manufacturers.