Nikkiso's FDY series is a high-flux hemodialyzer with enhanced sieving coefficient profile for HD, HDF and HF with 30 µm PEPA membrane and asymmetrical 3-layer structure. It facilitates very low albumin loss, high endoxin retention ability and low blood side pressure drop due to its 210µm capillary lumen. This triple safety system is the special advantage of the PEPA membrane, which is also used in the dialysate filters of the EF series. The FDY series allows an increased clarification performance for small and medium-sized molecules, enhanced purification performance for low molecular proteins and enhanced biocompability and antithrombogenicity. Indeed, getting closer to nature was Nikkiso's objective during the development process of the FDX and FDY dialyzers generation