Study: High-Grade DCIS Detection Increases with Age
DCIS, which is confined to the milk ducts, is a common finding on mammography. DCIS treatment, usually in the form of surgery and radiation therapy, is controversial because some types of screening-detected DCIS may never progress to become clinically symptomatic during the patient's remaining lifetime, and treatment can result in significant costs and potential complications for the patient.
DCIS is graded based on how the cancer cells from biopsy samples look under the microscope. Although high-grade, intermediate-grade and low-grade DCIS can all develop into invasive cancer if left untreated, high-grade DCIS develops faster and becomes a more aggressive, invasive cancer.
This retrospective study included 733,905 women aged 50 to 69 years participating for the first time in a screening programme. Researchers divided the participants into five-year age groups and then determined DCIS detection rates for distinguishing high-grade, intermediate-grade and low-grade DCIS.
Results showed that 989 of the participants (1.35 percent) had graded DCIS diagnosis, including 419 with high-grade DCIS, 388 with intermediate-grade DCIS and 182 with low-grade DCIS. Researchers also found that total DCIS detection rates increased with age, mostly due to a rise of high- and intermediate-grade DCIS.
"The detection rate of high-grade DCIS in our collective showed a statistically significant increase with age, with a maximum rate at the oldest assessed age group of 65 to 69 years," says lead author Stefanie Weigel, MD, from the University Hospital Muenster in Muenster, Germany.
The findings underscore the need for more research on the effectiveness of standard DCIS therapy in women older than age 60, a group for which there are scant data, adds Dr. Weigel.
The results also provide more information to consider in the debate over screening in older women. The American Cancer Society advises women to get annual screening for as long as they are healthy, while the U.S. Preventive Services Task Force (USPSTF) recommends women stop annual screening at age 74. The USPSTF based its decision on a lack of evidence to assess the benefits and harms of screening mammography in women ages 75 and older.
According to Dr. Weigel, "The discussion about upper age limits and minimal intervals in mammography screening should be focused on effectiveness of detection of invasive cancers."
Source and image credit: Radiological Society of North America
Published on : Tue, 27 Oct 2015
The new 3Dimensions™ Mammography System matches the unrivaled performance of our 3D Mammography™ exam, which is more accurate than conventional 2D mammograms, detecting 20-65% more invasive breast cancers. Breakthrough improvements transform the patient...
The Next Evolution in Ultrasound, designed for high expectations ARIETTA 850 ultrasound platform responds to high expectations to answer the ever increasing demands of medical professionals. ARIETTA 850’s fundamental performance has been refined...
Digital electrocardiograph / 16-channel / with touchscreen CARDIOVIT AT-170 SCHILLER
Robust design with high-performance
SCHILLER’s new high-end electrocardiograph AT-170 completes the proven AT product range. It offers robust design for the busiest hospitals, as well as a combination of applications that makes it the ideal multi-use workstation for private practices....
The enlightened choice for high-field MRI ECHELON Smart is Hitachi’s smart MRI concept which combines ‘SmartQUALITY’ for superb clinical images and sophisticated applications, ‘SmartSPEED’ for reduced examination time, ‘SmartCOMFORT’ for an extraordinary...
The first wireless, handheld breast ultrasound scanner with exceptional image quality Optimized with preset modes for breast, dense breast and interventional procedures that simplify workflow On-demand high-resolution images – 14 MHz, 192 elements, and...