Experts: Diagnostic Radiation Exposure 'Safe for Children'
Ionising radiation is widely thought to increase one's risk of getting cancer. However, researchers claim the long-held belief that even low doses of radiation, such as those received in diagnostic imaging, increase cancer risk is based on an inaccurate, 70-year-old hypothesis and leads to unnecessary fear and misdiagnoses.
The hypothesis referred to is the linear no-threshold hypothesis (LNT) promoted by Nobel Laureate Hermann Muller in 1946. Muller stated that the dose-response relationship is linear with no threshold dose, i.e., all radiation is harmful, regardless of how low the dose and dose rate.
"The underlying intent of lowering future cancer risk, although desirable, goes astray, as the premise is based on the erroneous LNT and the resulting as-low-as-reasonably-achievable (ALARA) principle," asserts Jeffry A. Siegel, PhD, president and CEO of Nuclear Physics Enterprises, Marlton, New Jersey. "The assumption ignores evidence-supported adaptive responses that either repair mutations through enhanced repair enzymes or remove the unrepaired cells by apoptosis [death of cells as part of normal growth] or, most importantly, the immune system."
Siegel and colleagues published an article in The Journal of Nuclear Medicine, in which they evaluate evidence refuting the LNT hypothesis and corollary efforts to reduce radiation exposure from computed tomography (CT) and nuclear medicine imaging in accord with the ALARA Principle. The authors assert that exposure to medical imaging radiation not only doesn't increase an adult person's risk of getting cancer, it doesn't increase a child's risk.
Children are generally considered to be more vulnerable and, therefore, more sensitive to the effects of radiation than adults. Siegel points out, "...much of the current thinking about the risks of ionising radiation is based on certain interpretations of the Hiroshima/Nagasaki life-span study."
The problem is that the study is interpreted incorrectly, Siegel says, noting that Japanese children younger than six at the time of the bombings at the end of World War II and exposed to radiation up to 200 mSv showed no significant difference in adult-onset cancers when compared with a control group. He adds, "Supportively, the French Academy of Sciences reported that these data provide evidence for protective adaptive responses and no valid evidence for harm below 100 mGy."
Nuclear medicine and CT radiation doses are low, and Siegel cites studies that show "initial radiation-induced damage is generally repaired or eliminated in a matter of hours by the body's adaptive responses." In addition, older children have a stronger immune system than adults. Siegel says, "low-dose radiation has been shown to stimulate the immune system to reduce cancer rates."
He emphasises the importance of diagnostic quality and says, "Accurate information about low-dose radiation is the only way to undo fear. ...Radiophobia is detrimental to patients and parents, induces stress and leads to suboptimal image quality or avoidance of imaging, thus increasing misdiagnoses and consequent harm while offering no compensating benefits."
Source: Society of Nuclear Medicine and Molecular Imaging
Image Credit: frankieleon
Published on : Mon, 12 Jun 2017
A breakthrough in biopsy efficiency The Brevera system streamlines the entire breast biopsy process from start to finish – with real-time imaging for instant verification and automated post-biopsy specimen handling. This has the potential to...
The best patient care is your ultimate goal. To achieve this requires confident diagnosis even with daily increases in patient throughput. Built on the foundation of Mindray’s continuous customer insights into clinical needs and the inheritance from...
The SonoSite EDGE II is a high-resolution, all-digital, 9.0-pound (4.1 kg) ultrasound system with a 12.1in. LED full-bleed glass display. The Edge II boosts improvements in cardiac and abdominal image quality through DirectClear Technology and a new...
BioZorb® 3D Bioabsorbable Marker The BioZorb® is a 3D implantable marker that consists of a spiral, bioabsorbable framework embedded with 6 permanent, titanium clips designed to precisely mark your surgical excision site. Designed to improve outcomes...
We recognize that the best chance any patient has at getting better is a clinician at their bedside with all the right answers and the confidence to act. SonoSite education and training is the industry standard – no other point-of-care ultrasound manufacturer...