Dual-agent PET/MR Detects More Cancer, Reduces Radiation

Tc-99m MDP bone scan (left) is negative for osseous lesions. NaF/FDG PET/MRI (right and second slide) confirms absence of bone metastases, but shows liver metastases.
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New research presented at the 2017 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging (SNMMI) shows that simultaneous injections of flourine-18 fluorodeoxyglucose (18F-FDG) and 18F-sodium fluoride (18F-NaF) followed by quantitative scanning significantly improves image quality and detection of bone metastases at a lower dose.

Andrei Iagaru, MD, associate professor of radiology and division chief, Nuclear Medicine and Molecular Imaging, Stanford University School of Medicine in Stanford, California explains that in some patients with breast and prostate cancer, a single PET/MR exam can not only reduce radiation but also provide accurate information. This is convenient for patients and less costly overall. 

Dual-agent PET/MR with time of flight approximates the position photons created as radioactive agents decay. This results in a much finer quality of images. 

The study enrolled 55 cancer patients (39 men with prostate cancer and 17 women with breast cancer) who were in line for a conventional bone scan. Study participants received simultaneous injections of the imaging agent 18F NaF. After that, they underwent PET/MRI scans. Results were compared with conventional technetium 99m-methyl diphosphonate (99mTc MDP) bone scintigraphy. 

Findings showed improved detection of prostate and breast cancer with dual-agent PET/MR. Bone metastases was pointed out in 22 patients who were also found positive with conventional base scan. However, PET/MR detected bone metastases in 14 patients as compared to conventional bone scan. 

Researches thus conclude that PET/MR successfully detected greater extent of metastases while reducing the required radiation dose from the injected agents.  

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Published on : Fri, 16 Jun 2017


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Cancer, radiation exposure, Dual-agent PET/MR, bone metastases New research presented at the 2017 Annaul Meeting of the Society of Nuclear Medicine and Molecular Imaging (SNMMI) shows that simultaneous injections of flourine-18 fluorodeoxyglucose (18F-FDG) and 18F-sodium fluoride (18F-NaF) followed by quantitative sc

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