Transplant Organs Supercooled For Longer Storage
Human organs cannot be frozen without incurring irreversible damage to delicate tissues. However, without some type of cooling, donated organs rarely remain healthy for more than a day. The scientists involved in the current study injected rat livers with anti-freeze and a glucose compound, which allowed the organs to be saved for a prolonged period without actually freezing them to the -320.8 degrees Fahrenheit (-196 degrees) required for cryopreservation.
In the study, none of the rats, whose livers were transplanted using current methods, survived for at least three months. Meanwhile, all of the rats who received supercooled livers survived three months or more when the livers had been stored for three days or less. The survival rate for rats, whose supercooled livers had been stored for four days, was 58 percent.
Organ transplants are time-sensitive, precisely because of the limited number of hours that tissue can remain healthy in storage. The technology currently used to preserve organs uses chemicals and cold temperatures, but 24 hours is considered the maximum time to transport the donated organs from donor to recipient. By having a wider window of time to transport the organ and to prepare patients and doctors for transplant surgery, the urgency of the operation is greatly reduced.
There are thousands of people on organ transplant lists. In Britain alone, 7,000 people are waiting, with half unlikely to find a matching donor in the current year. By 2015, approximately 1,000 people will die waiting for a transplant of some kind. The new storage technique therefore has the potential to save lives if it becomes safe for human donor organs.
There is a worldwide organ donor shortage, exacerbated by transportation times. Considering the larger distances that can be covered in four days compared to 24 hours, transcontinental transplants of donated organs will be facilitated by the new storage technique. With more organs available on a global level, patients are more likely to find a compatible match based on factors such as age, blood type and genotype.
Future research will have to focus on animals larger than rats, but the breakthrough is being welcomed as promising news by scientists. In addition to expanding the preservation time and geographic reach of donor organs, new possibilities will be allowed to emerge about how organs can be used to benefit patients.
Source: The Telegraph
Published on : Thu, 3 Jul 2014
Features SV 300 is a state-of-the-art ventilator that’s simple to configure, easy to operate and versatile in use. It equips with extensive ventilation modes that can treats pediatric and adult patients with all acuity levels at ICUs and Intermediate...
Q-NRG is the first Indirect Calorimeter specifically intended for the measurement of Resting Energy Expenditure (REE) in patients who are mechanically ventilated or spontaneously breathing and for healthy subjects. Q-NRG is a unique product, resulting...
Designed for many applications. Venue is a multi-purpose, point of care system that is also well-suited to help you manage patients in shock. It includes automated tools that enable you to quickly get the information you need to make fast decisions...
The HAMILTON-C1 neo is a versatile neonatal ventilator that combines invasive and noninvasive modes with the additional options of nCPAP and high flow oxygen therapy. The integrated turbine allows it to be operated independently of a compressed air supply....
A high-end ventilator featured with 1080P HD wide screen, combines an intuitive customized UI with powerful assistive tools and modules. Operate with Ease In the modern busy clinical environment, ease of use is a fundamental requirement for all...