New ‘Robust’ Treatment for Stroke Uses Genetic Material From Bone Marrow
“In this study we pioneered a totally new treatment for stroke, and possibly for all neurological disease,” says Michael Chopp, Ph.D., scientific director of the Henry Ford Neuroscience Institute.
The new study is published online in the current issue of Journal of Cerebral Blood Flow and Metabolism.
It focused on exosomes, blister-like microscopic “bubbles” that once were thought to carry and get rid of “old” proteins that were no longer needed by the body. After they were recently found to also carry RNA, whole new fields of study were suggested – including the pioneering work at Henry Ford.
The research team found that after inducing stroke in lab rats, injecting exosomes containing this genetic material into their blood prompted remodeling of the affected brain, including increased production of new brain cells, blood vessels and neural rewiring. Together, these effects significantly improved neurological function that had been impaired by stroke.
Using bone marrow from the adult rats, the researchers extracted stem cells – specifically mesenchymal cells, or MSCs – that were then employed to generate exosomes.
The researchers induced stroke by occluding an artery in the brain of each rat to block blood flow for two hours. Twenty-four hours later, they injected the exosomes into a vein in each rat’s tail.
The rats’ physical agility and neurological responses were tested before stroke and after treatment with the exosomes, and the results were compared.
“All rats showed severe functional loss one day after treatment, but gradual and eventually significant improvement during the four-week period that followed,” Dr. Chopp says. “This discovery provides a novel treatment for stroke, and possibly other neurological diseases.”
Dr. Chopp and Henry Ford researchers earlier found that the beneficial effects of treatment of stroke with bone marrow cells are attributed to their production and release of exosomes. In addition, using a similar treatment with exosomes from bone marrow stem cells significantly reduced a particularly resistant form of malignant brain tumor in living lab rats.
Source: Henry Ford Health System
Published on : Tue, 27 Aug 2013
The system is easy to use and delivers incredibly fast, accurate, and standardized results with minimal centrifugation time of five minutes. Beyond Results. Confidence. Leverage the comprehensive power of Ortho’s trusted testing menu....
Designed for many applications. Venue is a multi-purpose, point of care system that is also well-suited to help you manage patients in shock. It includes automated tools that enable you to quickly get the information you need to make fast decisions...
Streamlined for productivity Specifically designed to be easily integrated into each stage of the laboratory workflow all the way from pre-analytic to post-analytic solutions, the VITROS ® 4600 System is a medium chemistry platform with parallel...
Intended for uncomplicated, atraumatic endotracheal tube exchange. Features and benefits The blunt, soft, and flexible tip of the catheter is atraumatic to internal structures. The distal section of the catheter is flexible. The extra-firm...
Closed System Gastric Residuals Aspiration and Measurement Accessory Nurse Convenience Compat Modum is designed to ease gastric fluid aspiration and measurement. It enables closed system gastric residuals aspiration into a collection bag, reducing...