Alleviating ICU survivors' burden - a consensus of 29
In a review paper, a team of international researchers highlights how critical illness and critical care affect longer-term outcomes. According to the authors, the severity of acute illness determines the degree of impairment (with age and length of ICU stay) and the chronic disease status determines the trajectory of recovery.
Over the past 25 years there has been a burgeoning critical care literature addressing the issue of longer-term outcomes, including survival, quality of life, morbidity, functional status, joblessness, and costs of care for ICU survivors.
In the article, longer-term outcomes are analysed as the result of both the acute illness (pneumonia, trauma, stroke, anoxic brain injury, myocardial infarction, spinal cord injury, burn, etc.) and the critical care experience and related burden. "It is likely that most of the deleterious effects of critical care also apply to acute care, with regard to both the prevalence and the mechanisms that lead to weakness, delirium, cognitive impairment, worsening of chronic organ dysfunction, or any other significant sequels," the authors write.
Specifically, the article seeks to underline the contribution of ICU delirium to cognitive dysfunction following ICU discharge. Delirium and its duration are associated with neurocognitive dysfunction and may be associated with mortality over the first year after critical illness. "One year after ICU discharge, up to one-third of patients have symptoms of depression, but pre-illness psychiatric history can be found in only 11-38% of patients. The link between pre-illness and post-ICU psychiatric disorders is not yet completely understood," the authors point out.
The article also provides new insights into ICU acquired weakness. Respiratory muscle weakness, and more particularly diaphragmatic dysfunction, has been reported in about half of patients at the time of ICU admission and are associated with increased mortality.
"Ventilation-induced diaphragmatic dysfunction occurs in half the patients after prolonged controlled mechanical ventilation or ventilation with high-level support, but can also be caused by sepsis alone (without prolonged mechanical ventilation)," the authors explain. "Diaphragmatic weakness follows muscle fibre injury, atrophy, and remodelling and is associated with asynchrony, weaning failure, prolonged ventilation, and ICU and hospital readmission."
Although weakness may not be documented at clinical examination a long time after ICU discharge, the authors note that all patients report varying levels of perceived weakness that prevents them from performing vigorous exercise. They say that further studies focused on early physical therapy are needed to determine the most appropriate target population who are most likely to benefit.
The authors emphasise the need to develop effective interventions – i.e., tested and implemented at various levels – to improve patients’ and caregivers’ abilities to cope with critical illness and its sequelae (prevent tissue impairment, rehabilitate activity limitations, compensate limitations, or adapt with reduction in quality of life). Some evidence exists that rehabilitation should start early during critical illness, but modalities of rehabilitation remain to be tested and clarified. Also, long-term chronic pain, addiction, and dependencies need to be studied in ICU survivors using valid tools that help us understand predictors of ICU-related opioid dependency.
"Furthermore, patients’ and family members’ experiences should be used to guide effective interventions to provide the best comfort and holistic care, to better address the needs of patients and their families, and improve our ability to alleviate the post-ICU burden for surviving patients and their loved ones, as well as the grief symptoms of bereaved family members," the authors write.
Source: Critical Care
Image Credit: Pixabay
Published on : Wed, 13 Dec 2017
The only glucose meters cleared by US FDA and Health Canada for use with all patients, including critically ill Because of the unacceptably high rate of adverse patient events, including deaths, linked to the point-of-care (POC) use of glucose...
Not available in all markets Exceptional Simplicity in a New Generation Electrolyte Analyzer Introducing a new generation electrolyte analyzer that combines the revolutionary microelectronics of the consumer world with new microsensor...
Dual-lumen Jejunal Feeding Tube with Integrated Gastric Drainage Clinical Performance Compat Stayput is designed to be able to be placed using a variety of placement techniques at/or beyond the Ligament of Treitz. Nurse Convenience...
Standardized extracorporeal tubing sets for short-term use • Standardized extracorporeal tubing set • Available in three different sizes (for infants, pediatrics and adults) • Approved for 6 hours of use • Rheoparin coating, the established Medos heparin...
New Technologies Simplify Use and Offer Additional Tests Stat Profile Prime Plus is a comprehensive, whole blood critical care analyzer that combines blood gases, electrolytes, metabolites, CO-Oximetry, and 32 calculated results in a simple, compact...