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Department of Intensive Care & Laboratory of Experimental Intensive Care and Anesthesiology (L·E·I·C·A) Academic Medical Center Amsterdam, the Netherlands
CO 2 exerts potent effects on lung biology that could be clinically relevant in critically ill patients, in particular those with acute respiratory distress syndrome (ARDS). The impact of hypercapnia on outcome in these patients is yet to be determined. The physiological effects of hypercapnia are increasingly well understood, but the literature remains confusing. Important insights have emerged...
READ MOREInvasive ventilatory support, one of the most frequently applied strategies in intensive care unit (ICU) patients, is increasingly recognised as a potentially dangerous intervention. Recognition of so–called ventilator– induced lung injury and the broad acceptance of lung–protective ventilation strategies in ICUs worldwide led to noticeable changes in ventilatory management (Putensen et al. 2009;...
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