Heparin-Induced Thrombocytopaenia

• 20/04/2023

Heparin-induced thrombocytopaenia (HIT) is an immune complication of heparin therapy. This review discusses the pathophysiology, incidence, clinical manifestations, diagnostic approach, and management of patients with HIT.   Pathophysiology HIT is an immune complication of heparin therapy caused by IgG antibodies to complexes of platelet factor 4 (PF4) and heparin. These antibodies bind...