Search Tag: Sepsis

ICU Management

Machine Learning to Predict Severe Sepsis and Septic Shock

2019 21 Oct

Sepsis is a major cause of death among hospitalised patients. It affects nearly 6% of all admissions and results in in-hospital mortality of greater than 15%. Early detection could reduce mortality, as it would result in the timely implementation of evidence-based interventions.  Clinical researchers have developed and implemented a machine-learning... Read more

ICU Management

ESICM LIVES Forum 2020

2020 14 May

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ICU Management

#LIVES2019: Vitamin C for Sepsis

2019 04 Oct

Dr. Alpha A. Fowler of Virginia Commonwealth University presented findings from the CITRIS-ALI trial that studied the role of vitamin C in patients with septic ARDS. The findings were presented @ESICM in Berlin and have just been published in JAMA.  The CITRIS-ALI randomised trial addressed the use of high dose intravenous vitamin C to study... Read more

ICU Management

Nutrition

2019 26 Sep

The critically ill patient is often unable to feed by mouth. This condition, in some patients, can range from days to months. It is imperative that these patients receive macronutrients either through enteral or parenteral nutrition. If they don't, there is a risk of an energy deficit that could lead to loss of lean body mass and subsequently, other... Read more

ICU Management

Blood Cultures Before Sepsis Treatment

2019 20 Sep

Severe bacterial infections pose a significant threat to public health, with 1.7 million people in the U.S. infected with sepsis every year. There has been a constant debate within medicine as to when treatment should be administered.   Current guidelines state that blood cultures should be taken before antimicrobial treatment is initiated, as is... Read more

ICU Management

Neonatal Early-Onset Sepsis Calculator

2019 13 Sep

In 2007, a study funded by the National Institutes of Health assessed the use of predictive models to calculate the risk of early-onset sepsis (EOS) in neonatal patients, accounting for multiple variables.   The main objectives of the study were to assess the links between the risk factors and the infection outcomes; use patient data collected from... Read more

ICU Management

Understanding the Influenza Virus

2019 25 Jul

Diagnosis of the Influenza virus remains a challenge in the ICU. It is vital that knowledge of its pathophysiology and epidemiology is known so clinicians can make informed decisions regarding their patients’ health.   The Influenza virus is found most commonly to replicate in the respiratory tract in humans. This is mainly due to the haemagglutinin... Read more

ICU Management

Monocyte Distribution Width as Biomarker for Early Sepsis Detection

2019 25 Jul

Existing biomarkers provide limited use for rapid detection of sepsis since they cannot accurately distinguish sepsis from other common conditions encountered in the emergency department (ED). Now a U.S. clinical trial suggests that the monocyte distribution width (MDW) can be a useful indicator of Sepsis-2 and Sepsis-3 in high-risk ED patients. "Changes... Read more

ICU Management

Vitamin C Drug Cocktail for Sepsis

2019 09 Jul

The combination of intravenous vitamin C, corticosteroids and thiamine has been made famous by Dr. Paul Marik, M.D. for the treatment of sepsis in critically ill patients. The ‘Marik protocol’, also termed HAT (Hydrocortisone, Ascorbic acid, Thiamine), has however come under criticism regarding the lack of evidence. Dr. Marik of Sentara Norfolk... Read more

ICU Management

Promising Ideas for Future Intensive Care

2019 26 Jun

The path to innovation is often based on intuition or insight. But the implementation of new ideas in healthcare requires rigorous testing and confirmation.  However, one can argue that in the field of critical care, this cautious approach has let clinicians down. There is no doubt that clinical trials are important, but at the same time, they... Read more