Search Tag: Sepsis
2025 15 Apr
Sepsis remains a major cause of illness and death among children worldwide. Although mortality has decreased due to quality improvement initiatives and clinical guidelines, 4–10% of paediatric sepsis cases still result in death, often due to refractory shock or multiorgan dysfunction. For children with persistent shock despite fluid resuscitation,...Read more
2025 03 Apr
Sepsis remains a major global health issue, with nearly 49 million cases and 11 million deaths annually. International guidelines emphasise routine screening and standardised treatment protocols for high-risk patients. The World Health Assembly’s 2017 Resolution 70.7 and the G7 Health Ministers’ 2022 statement have called for enhanced prevention, diagnosis,...Read more
2025 27 Mar
The basics of vasopressor support and advanced considerations regarding its early use in intensive care settings. Introduction The use of vasopressors in critical care is a crucial aspect of haemodynamic management. While norepinephrine remains the primary agent of choice, the role of other vasopressors such as vasopressin has gained...Read more
2025 25 Mar
Sepsis is a major cause of death and disability. The Centers for Medicare & Medicaid Services (CMS) aims to improve sepsis outcomes through the Severe Sepsis and Septic Shock Management Bundle (SEP-1), which hospitals must report compliance with. SEP-1, based on the Surviving Sepsis Campaign bundle, is linked to lower mortality rates. CMS...Read more
2025 20 Mar
Pancreatic stone protein (PSP), C-reactive protein (CRP), and procalcitonin (PCT) are potential biomarkers for early detection of infection and sepsis in critically ill patients. A poster presentation @ISICEM on Pancreatic Stone Protein (PSP) highlighted how this biomarker plays a role as an early sepsis predictor. The study aimed...Read more
2025 19 Mar
The complexity of clinical trials in critical illness remains a significant challenge. A discussion at the ISICEM Congress in Brussels focused on why trials often fail, the role of heterogeneity in patient responses, and emerging methodologies to improve our understanding of pathways to outcomes. For over 30 years, researchers have debated...Read more
2025 18 Mar
Sepsis is a common and potentially fatal condition, causing over 270,000 deaths annually in the U.S. Emergency treatment involves fluids and vasopressors, with norepinephrine as the first-line choice and vasopressin as a second-line option when blood pressure remains unresponsive. However, the timing of vasopressin use is unclear due to the dynamic...Read more
2025 12 Mar
Early recognition and treatment of sepsis are crucial for improving patient outcomes, leading to clinical guidelines recommending sepsis screening programmes. However, evidence supporting these programmes is limited. Observational studies suggest screening improves care processes , such as timely lactate measurement and antibiotic administration,...Read more
2025 12 Mar
Sepsis is a major cause of mortality worldwide, with intravenous crystalloid infusion being the first-line treatment to maintain organ perfusion. However, fluid overload is associated with poor outcomes, and restrictive fluid therapy has not shown benefits. Albumin, due to its molecular properties, may help retain fluid intravascularly, but its volume-sparing...Read more
2025 17 Feb
Sepsis is a major but often overlooked cause of death and disability. In 2017, there were an estimated 48.9 million cases of sepsis, causing 11 million deaths worldwide. Sepsis is more common in lower-income regions, and its incidence is expected to rise as populations age. Severe forms of sepsis, such as septic shock, have high mortality rates,...Read more
2025 17 Feb
Sepsis, as defined by Sepsis-3, is a life-threatening organ dysfunction caused by a dysregulated response to infection, with high mortality rates, especially in septic shock. Sepsis can cause acute myocardial injury, and high-sensitivity cardiac troponin (hs-cTn) assays are increasingly used to detect cardiac injury in these patients. While previous...Read more
2025 17 Feb
Vasopressors are commonly used in critically ill patients to increase vascular tone in cases of severe hypotension with signs of altered tissue perfusion, such as poor skin perfusion, altered mental status, or decreased urine output—indicative of shock. Shock is associated with elevated lactate levels (>2 mmol/L) and can be classified into four types:...Read more
2025 10 Feb
Dementia is a progressive neurodegenerative disease with growing public health and economic implications. In 2019, 57.4 million people had dementia worldwide, a number projected to reach 152.8 million by 2050. The global financial burden is substantial, estimated at $1.31 trillion annually. As dementia prevalence rises, increased healthcare resources...Read more
2025 27 Jan
Over 50 RCTs have examined resuscitation strategies in sepsis, but the optimal approach remains unclear. Early goal-directed therapy (EGDT), a 6-hour protocol involving fluids, vasopressors, inotropes, and blood products, showed a significant reduction in mortality in a landmark trial. However, subsequent larger trials did not replicate these benefits,...Read more
2025 07 Jan
Sepsis is a life-threatening condition caused by a dysregulated host response to infection, leading to organ dysfunction. Sepsis involves both pro-inflammatory and anti-inflammatory processes, which can occur early in the disease and explain the severe clinical outcomes such as septic shock and premature death. However, each patient follows a unique...Read more
2024 10 Dec
Sepsis is a common cause of ICU admissions and mortality, with its incidence increasing over recent decades. Although hospital mortality has declined, long-term mortality remains high, with 1-year mortality rates for survivors ranging from 7% to 44% and over 2-year mortality exceeding 53%. Factors contributing to this risk are debated, including...Read more
2024 28 Nov
Abionic, an innovative medical diagnostics company specialising in rapid early detection technologies, has received 510(k) clearance from the U.S. Food and Drug Administration (FDA) for its IVD CAPSULE PSP test. Abionic, an emerging medical diagnostics company focused on rapid early detection technologies, received 510(k) clearance for...Read more
2024 28 Nov
Vasopressin timing, patient selection, optimal vasopressin use in septic shock, and potential mortality benefits in selected patient populations. Septic Shock Overview and Current Treatments Septic shock is a severe, life-threatening response to infection, characterised by systemic inflammation, tissue hypoperfusion, and persistent,...Read more
2024 21 Oct
Sepsis affects nearly 50 million people globally. Survivors face significant long-term issues like reduced quality of life and frequent hospital readmissions. Studies show that 21.4% of survivors are readmitted within 30 days and 39% by one year, with sepsis-related readmissions being costlier than those for other conditions like heart failure or myocardial...Read more
2024 18 Oct
Half of all patients admitted to an emergency department with sepsis died within two years, according to a Danish study aimed at identifying factors that could predict patient outcomes. These findings were presented at the European Emergency Medicine Congress. Study researchers analysed a cohort of 714 adult sepsis patients, revealing key risk...Read more
2024 16 Sep
Mechanical ventilation (MV) can be both beneficial and harmful for critically ill patients. It improves gas exchange, reduces the work of breathing, and lowers self-inflicted lung injury risk. MV, often accompanied by sedatives and neuromuscular blockers, can also reduce oxygen consumption and carbon dioxide production, and in patients with cardiac...Read more
2024 02 Sep
A recent review addresses the challenge of categorising new persistent symptoms that patients experience after recovering from ICU-treated sepsis caused by COVID-19. It explores whether these symptoms fit into one of the following categories: Long-COVID, Post-Sepsis Syndrome, or Post-Intensive-Care Syndrome. It also considers if patients might...Read more
2024 29 Aug
A new artificial intelligence tool, SepsisLab, has been developed to assist clinicians in making decisions about hospital patients at risk for sepsis, with a distinctive feature: it acknowledges its uncertainty. It indicates which demographic data, vital signs, and lab test results are needed to enhance its predictive accuracy. The research was published...Read more
2024 05 Aug
Sepsis is a life-threatening organ dysfunction caused by a dysregulated response to infection. It is responsible for approximately 50 million cases and 11 million deaths worldwide, accounting for about 20% of all global deaths. The challenge in accurately estimating sepsis and its associated mortality stems from varying definitions, diagnostic...Read more
2024 24 Jul
Sepsis is a global health issue with high mortality and morbidity rates among hospitalised patients. To enhance the quality of sepsis management, the Surviving Sepsis Campaign (SSC) developed an evidence-based bundle comprising five key elements to be implemented within the first hours of sepsis recognition. These elements include fluid resuscitation...Read more
2024 22 Jul
The clinical course and outcomes of sepsis vary widely, but early recognition and intervention with fluids, vasoactive agents, and antimicrobials significantly reduce morbidity and mortality. However, beyond supportive care, therapeutic options for sepsis are limited. Many biomarkers are associated with sepsis severity and outcomes, but their...Read more