Search Tag: Sepsis
Early IV fluid treatment and sepsis mortality
2018 18 Dec
Intravenous (IV) fluids provided by paramedics were associated with reduced in-hospital mortality for patients with sepsis and hypotension but not for those with a higher initial systolic blood pressure. This is the central finding of a large cohort study (n = 1,871 patients) conducted in Canada and published by JAMA Network. Early IV fluid... Read more
Study: sepsis-induced DIC associated with high mortality
2018 27 Nov
Researchers in Japan conducted a multicentre retrospective observational study to investigate the epidemiology of disseminated intravascular coagulation (DIC) in patients with sepsis. They found that patients with DIC diagnosed by two consensus criteria had higher severity and in-hospital mortality than patients without DIC. The study results confirm... Read more
Metabolic-based biomarkers have potential to triage children with sepsis
2018 14 Nov
A new study has validated potential biomarkers for a sepsis-triage model to distinguish sepsis patients requiring care in the paediatric intensive care unit (PICU) from sepsis identified in the paediatric emergency department (PED) that does not require ICU admission. The study, led by Beata Mickiewicz and colleagues from the University of Calgary... Read more
'AI Clinician' can aid doctors in treating sepsis patients
2018 31 Oct
Researchers from Imperial College London have created an artificial intelligence system that could help treat patients with sepsis. Aptly named AI Clinician, the system could predict the best treatment strategy for patients. Tests conducted by the researchers showed that 98 percent of the time, the AI system matched or was better than the human... Read more
Extracorporeal techniques in sepsis treatment: benefits and risks
2018 31 Oct
Sepsis, a leading cause of morbidity and mortality worldwide, is characterised by a dysregulated immune response to infections that results in life-threatening organ dysfunction. Conventional therapy of sepsis typically starts with resuscitative measures; however, the only definitive therapy is adequate antibiotics and source control in surgical... Read more
Patients with AKI and sepsis: when to initiate renal-replacement therapy
2018 17 Oct
Among patients with septic shock who had severe acute kidney injury (AKI), there was no significant difference in overall mortality at 90 days between patients who were assigned to an early strategy for the initiation of renal-replacement therapy and those who were assigned to a delayed strategy, according to a randomised controlled trial published... Read more
Stronger evidence for vitamin C use in sepsis treatment
2018 17 Oct
A new meta-analysis reveals a positive correlation between incorporating vitamin C in the treatment of sepsis and favourable patient outcomes. Results of the meta-analysis showed a marked reduction in mortality and duration of vasopressor administration in the group with the use of vitamin C, despite varying degrees of statistical significance between... Read more
Shock
2018 16 Oct
Shock is an emergency, and if it is not treated, it will mostly be fatal. Early intervention and admission to the ICU is essential. Our cover story considers several aspects of shock, including pathophysiology and multi-organ dysfunction syndrome, as well as source control, fluids, differentiation using point-of-care ultrasound and vasoactive medication.... Read more
Pathophysiology of endotoxic shock
2018 16 Oct
Mechanisms of endotoxin-induced multi-organ damage. Endotoxin-induced sepsis remains a leading cause of mortality in intensive care units (ICUs) worldwide. Lipopolysaccharide (LPS) identification by the immune system triggers a cascade of signalling pathways, leading to the release of several cytokines and chemokines, which orchestrate the... Read more