Search Tag: Sepsis

ICU Management

Introduction-to-landiolol-in-acute-cardiac-care

2024 12 Mar

  An overview of landiolol, a potent and cardioselective beta-blocker offering a promising addition to the armamentarium for managing acute cardiac conditions for rapid and effective rate control with minimal adverse effects.   Cardiac emergencies present complex challenges in emergency medical settings, requiring prompt and effective management...Read more

Sepsis

Informative-subtyping-targeted-immunomodulatory-therapies-for-sepsis

2024 28 Feb

  Sepsis is characterised by dysregulated immune responses. Traditional approaches to treating sepsis by targeting proinflammatory and immunosuppressive responses have been largely unsuccessful. Recent efforts have shifted towards identifying subtypes of sepsis to enable personalised treatment. However, many important immunological concepts, such...Read more

Sepsis

Qsofa-with-supar-for-risk-detection-antibiotic-treatment-guidance

2024 13 Feb

  Early recognition and initiation of antibiotics are crucial in managing sepsis. Various warning scores, including qSOFA (quick Sequential Organ Failure Assessment), have been introduced to aid early detection. Patients with suspected infection and at least two of the qSOFA clinical signs are at a significantly higher risk of death after 28 days....Read more

Sepsis

Hydrocortisone-plus-fludrocortisone-for-cap-related-septic-shock

2024 13 Feb

  In a subgroup analysis of the Activated Protein C and Corticosteroids for Human Septic Shock (APROCCHSS) trial, researchers aimed to explore the effects of hydrocortisone plus fludrocortisone on patients with community-acquired pneumonia (CAP) compared to those with non-CAP-related septic shock. The goal was to determine whether glucocorticoids...Read more

Sepsis

Ai-surveillance-tool-to-predict-sepsis

2024 08 Feb

  Nearly 1.7 million adults in the United States contract sepsis annually, with approximately 350,000 succumbing to the condition.   In a recent study published in npj Digital Medicine, experts from the University of California San Diego School of Medicine harnessed an artificial intelligence (AI) model within the emergency departments of UC...Read more

Sepsis

Temporal-trends-in-mortality-of-patients-with-sepsis

2024 30 Jan

Sepsis, characterised by severe organ dysfunction, is a major cause of hospitalisation and mortality globally. The WHO recognises sepsis as a significant global health concern, urging efforts to enhance outcomes for affected individuals.  Despite no new targeted therapies emerging for sepsis in recent decades, advancements in ICU management, shifts...Read more

ICU Management

Key-updates-including-epv-for-managing-sepsis-and-septic-shock

2024 20 Mar

  Session One March 20, 2024 | 3:00 PM EST   Session Two March 28, 2024 | 1:00 PM EST   Session Three March 26, 2024 | 11:00 AM GMT   Read more

Sepsis

International-consensus-criteria-for-paediatric-sepsis-and-septic-shock

2024 23 Jan

In 2017, an estimated 25 million children worldwide experienced sepsis, resulting in over 3 million deaths. Paediatric sepsis survivors often face ongoing physical, cognitive, emotional, and psychological challenges. Children, particularly in lower-resource settings, face a higher risk of developing sepsis during their early years. The World Health...Read more

Sepsis

English-proficiency-and-sepsis-mortality

2024 16 Jan

Sepsis is a leading cause of hospital deaths. Despite initiatives like the Surviving Sepsis Campaign and Centers for Medicare & Medicaid Services Severe Sepsis and Septic Shock Management Bundle (SEP-1), healthcare disparities persist. Previous studies revealed disparities in sepsis outcomes by age, sex, race, and ethnicity, but limited English proficiency...Read more

Sepsis

Decoding-the-cytokine-storm-in-sepsis

2024 12 Jan

Sepsis is a prominent cause of mortality in ICUs. Despite extensive research on the dynamics leading to sepsis, the role of cytokines—immune system molecules that can cause substantial harm to the body—has remained inadequately understood. While these proteins typically regulate inflammation, an overly aggressive immune response can result in a cytokine...Read more

Sepsis

Return-to-work-after-hospitalisation-for-sepsis

2024 03 Jan

This study focuses on the impact of sepsis, a condition resulting from a dysregulated immune response to infection, on the ability of patients to return to work (RTW). Sepsis is a significant global health concern, causing substantial morbidity and mortality. Sepsis survivors commonly experience long-term cognitive and functional impairments, but the...Read more

ICU Management

Treating-the-whole-human-in-intensive-care-patient-centred-outcomes-in-sepsis-surgery-and-trauma

2023 30 Nov

Intensive care impacts more than the patient, with ripple effects for families, employers and wider societies. Patient-centred outcomes reiterate the need for clinical therapies targeting the biological circuitry of the big-hitting syndromes like ARDS, sepsis, delirium, renal failure and recognising they persist beyond the veil of discharge....Read more

ICU Management

Cardiovascular-management-in-septic-shock-optimising-vascular-and-cardiac-function

2023 30 Nov

An overview of vasopressor management, current evidence on its use, when to initiate vasopressor therapy for best possible patient outcome and a discussion regarding the use of landiolol in septic patients with persistent tachycardia.    Optimising Vasopressin Initiation in Septic Shock   Patients with septic shock, and especially...Read more

Cardiology Management

Cardiovascular-management-in-septic-shock-optimising-vascular-and-cardiac-function

2023 30 Nov

An overview of vasopressor management, current evidence on its use, when to initiate vasopressor therapy for best possible patient outcome and a discussion regarding the use of landiolol in septic patients with persistent tachycardia.    Optimising Vasopressin Initiation in Septic Shock   Patients with septic shock, and especially...Read more

Sepsis

Knowledge-and-awareness-of-sepsis-among-risk-populations

2023 22 Nov

Sepsis can have potentially life-threatening consequences. Early recognition is crucial for effective intervention. The role of patients in preventing and identifying sepsis early is vital. However, there is an incomplete understanding of sepsis knowledge among at-risk groups and their ability to recognise sepsis as a medical emergency. COVID-19...Read more

Sepsis

Uncovering-heterogeneity-in-sepsis

2023 08 Nov

Sepsis is a life-threatening condition caused by a dysregulated host response to infection. Despite progress in understanding its underlying mechanisms, there's no specific successful treatment for sepsis. Precision therapy is needed, and understanding the heterogeneity of sepsis is crucial. Recent methods have attempted to measure sepsis heterogeneity...Read more

ICU Management

Cardiovascular-management-in-sepsis-improving-cardiac-and-vascular-functions

2023 13 Oct

Vasopressin and landiolol are critical therapies for ensuring the vascular and cardiac systems are as close to optimal conditions as possible during septic shock. Better cardiovascular management in septic shock can help improve septic shock management.     Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response...Read more

ICU Management

Why-artificial-intelligence-is-not-fixing-the-problem-of-sepsis-in-the-hospital

2023 13 Oct

The use of Artificial Intelligence in detecting sepsis, AI prediction/detection models and how these healthcare tools need to complement clinical expertise.     The potential of Artificial Intelligence (AI) in healthcare has generated significant excitement and discussion. However, it's important to distinguish between the theoretical...Read more

Sepsis

Genetically-predicted-insomnia-and-risk-of-sepsis

2023 11 Oct

Insomnia, a common sleep disorder, has been linked to various adverse health outcomes, including altered immune function and elevated systemic levels of inflammatory markers, which may affect women more than men. Dysregulated immune responses can lead to conditions like sepsis, which has high morbidity and mortality. A study was conducted to determine...Read more

Sepsis

Data-to-track-incidence-mortality-for-sars-cov-2-associated-sepsis

2023 03 Oct

Sepsis is a life-threatening condition resulting from a dysregulated response to infection, historically associated with bacterial infections. However, viral infections are increasingly recognised as significant contributors to sepsis, especially with events like the SARS-CoV-2 pandemic and surges of respiratory viruses like RSV and influenza. Despite...Read more

ICU Management

World-sepsis-day-lets-work-together-to-encourage-and-support-sepsis-research

2023 12 Sep

A woman came to see me a few days ago: her 44-year-old husband recently died from sepsis in another hospital, and she wanted to have a discussion about this tragic story. Her husband had had just some kind of blister on his foot. He didn’t seem very ill when he arrived at the hospital, but he quickly developed an extended area of fasciitis on his left...Read more

ICU Management

Corticosteroids-in-severe-cap

2023 12 Sep

Corticosteroid use in the care of critically ill patients has been the subject of ongoing research with conflicting findings. There is a growing interest in understanding their role in treating a common source of sepsis: community-acquired pneumonia (CAP). Some studies have focused on determining whether corticosteroids provide clinical benefits to...Read more

ICU Management

World-sepsis-day-understanding-symptoms-better

2023 08 Sep

World Sepsis Day falls on September 13. Sepsis, which kills more people in Austria each year than heart attacks, is caused by an infection which spreads through the body and damages our organs. A lot of people in the general public still do not know very much about this issue.   Sepsis is one of the most common causes of death around the world....Read more

Sepsis

Angiotensin-ii-in-critically-ill-patients

2023 22 Aug

In December 2017, angiotensin II (ATII) intravenous infusion gained approval in the U.S. for treating septic or other distributive shock in adults. This approval was based on results from a phase II clinical trial which showed higher mean arterial pressure in septic shock patients on norepinephrine, who were randomly assigned to titrated ATII compared...Read more

ICU Management

The-promise-of-artificial-intelligence-in-critical-care

2023 01 Aug

Computer-based technologies, including artificial intelligence (AI) applications like ChatGPT and DALL-E, are being increasingly used and can mimic human capabilities, even passing medical board examinations. Retrospective studies have shown that machine learning (ML) applications are especially valuable in the ICU due to their diagnostic and prognostic...Read more

Artificial Intelligence

The-promise-of-artificial-intelligence-in-critical-care

2023 01 Aug

Computer-based technologies, including artificial intelligence (AI) applications like ChatGPT and DALL-E, are being increasingly used and can mimic human capabilities, even passing medical board examinations. Retrospective studies have shown that machine learning (ML) applications are especially valuable in the ICU due to their diagnostic and prognostic...Read more

Sepsis

Vasopressin-loading-for-refractory-septic-shock

2023 01 Aug

Vasopressin is a potent vasopressor used to treat septic shock, acting via a different receptor than catecholamines. Previous randomised control trials have demonstrated its efficacy. However, its use can also lead to adverse effects such as ischaemia events. Therefore, it is recommended as a second-line agent after noradrenaline.   Typically,...Read more