Search Tag: Sepsis

2026 07 Jun

Sepsis has consistently challenged clinicians. The discovery of antibiotics marked a major advance in the treatment of sepsis, yet germ theory alone did not fully explain its pathogenesis: many patients with sepsis continued to die even after antibiotic treatment had successfully eradicated the causative pathogen. It is now understood that the dys1Read more

2026 14 May

A recent study examined whether starting vasopressin earlier in the course of septic shock improves patient outcomes. Septic shock is a severe form of sepsis characterised by profound circulatory failure and high mortality. Norepinephrine is the recommended first-line vasopressor, but escalating doses can cause adverse effects such as arrhythmias 1Read more

2026 15 Apr

A recent review evaluated the association between socioeconomic position (SEP) and mortality among adults with sepsis and septic shock. Sepsis remains a leading cause of morbidity, mortality, and healthcare expenditure worldwide, and there is increasing recognition that social and economic factors may significantly influence patient outcomes. Whil1Read more

2026 09 Apr

A new review examines the effects of vasoactive medications on the microcirculation in septic shock to synthesise current knowledge and identify gaps in evidence. Sepsis remains a leading cause of inpatient mortality, with rates approaching 30%, and although management strategies focus on restoring macrohaemodynamic parameters such as mean arteria1Read more

2026 01 Apr

A new article reports the findings of the Tigris trial investigating the efficacy and safety of polymyxin B haemoadsorption in patients with endotoxic septic shock (ESS). ESS is a severe subtype of septic shock characterised by high circulating endotoxin levels and multiorgan failure, and is associated with a high mortality rate. Given the absence1Read more

2026 01 Apr

A recent article investigates the association between vitamin D status and the incidence of sepsis and subsequent mortality, using a large, population-based prospective cohort derived from the U.K. Biobank.   Sepsis, a life-threatening organ dysfunction caused by a dysregulated immune response to infection, represents a major global health b1Read more

2026 29 Mar

Pancreatic Stone Protein (PSP) earns its place in the 2026 Surviving Sepsis Campaign International Guidelines.    The new guidelines emphasise the increasing role of rapid diagnostic tools enabling early sepsis detection across emergency and critical care settings.   Pancreatic Stone Protein, running exclusively on the abioSCOPE® platf1Read more

2026 18 Mar

Sepsis is characterised by a dysregulated host response to infection that leads to life-threatening organ dysfunction. Although immune dysregulation is fundamental to its definition, most immunomodulation trials enrol patients based on clinical severity rather than the degree of immune disturbance, potentially contributing to variable treatme1Read more

2026 17 Mar

A landmark population-based study on the developmental risk factors and long-term consequences of sepsis was previewed at ISICEM this afternoon. Djillali Annane, director of the ICU and the IHU-PROMETHEUS Comprehensive Sepsis Center at Raymond Poincaré Hospital in Paris, presented early insights from the ongoing research in a French cohort.   1Read more

2026 04 Mar

The Albumin Replacement Therapy in Septic Shock (ARISS) trial, published in JAMA Network Open was designed to determine whether albumin replacement improves survival in patients with septic shock. The study was conducted on behalf of the SepNet Critical Care Trials Group and ARISS investigators.   Albumin is a natural colloid with physiologi1Read more

2026 17 Feb

The Sequential Organ Failure Assessment (SOFA) score is a cornerstone tool in intensive care medicine. Rather than serving primarily as a mortality predictor, it was designed to assess and monitor organ dysfunction in critically ill patients. It forms part of the diagnostic framework for sepsis, where an acute increase of two or more SOFA points c1Read more

2026 04 Feb

  Sepsis remains a leading cause of mortality and long-term disability in intensive care, with outcomes varying widely across hospitals despite advances in technology and repeated guideline updates. One persistent barrier is the fragmentation of clinical data, which limits the ability of clinicians, researchers and health systems to learn syste1Read more

2026 28 Jan

The TARTARE-2S trial investigated whether a haemodynamic strategy focused on improving tissue perfusion while permitting lower-than-recommended mean arterial pressure (MAP) could improve outcomes in patients with septic shock compared with conventional MAP-guided standard care. Current sepsis guidelines prioritise maintaining MAP targets, typicall1Read more

2026 15 Jan

Current approaches to classifying sepsis are limited because they rely too heavily on clinical features and host-only immune responses, while largely ignoring the role of the infecting microbes. Sepsis is a heterogeneous syndrome, and grouping patients based on clinical signs alone assumes a single underlying mechanism, which is often incorrect. T1Read more

2026 07 Jan

Sepsis is a critical medical emergency that requires prompt treatment with broad-spectrum antibiotics (BSAs) to cover potential multidrug-resistant organisms (MDROs). While early empiric BSA therapy has been associated with reduced mortality in high-risk patients and is recommended by the 2021 Surviving Sepsis Campaign Guidelines, prolonged exposu1Read more

2025 11 Dec

Sepsis is a life-threatening condition caused by a dysregulated immune response to infection. Many immunotherapy trials have failed because sepsis presents with highly variable immune states, ranging from excessive inflammation to profound immunosuppression. A precision-medicine approach, guided by rapid biomarker-based immune profiling, may there1Read more

2025 02 Dec

  Sepsis remains a major cause of in-hospital mortality worldwide and places a substantial burden on intensive care units and healthcare systems. Despite regular updates to clinical guidance and advances in treatment, outcomes for many patients remain poor and early identification of those at highest risk continues to be challenging. Convention1Read more

2025 02 Dec

  Sepsis remains a major cause of in-hospital mortality worldwide and places a substantial burden on intensive care units and healthcare systems. Despite regular updates to clinical guidance and advances in treatment, outcomes for many patients remain poor and early identification of those at highest risk continues to be challenging. Convention1Read more

2025 05 Nov

Sepsis remains one of the leading causes of death in intensive care units worldwide. Despite significant progress in early detection and management, antibiotic dosing protocols often fail to account for patient-specific factors, particularly those linked to biological sex and gender-related disparities in care.    A new editorial in the Jour1Read more

2025 29 Oct

The European Society of Intensive Care Medicine (ESICM) convened an international panel of experts to develop evidence-based guidelines on fluid resuscitation volumes for adult critically ill patients with circulatory failure. This guideline represents Part 2 of a three-part series on fluid management, focusing specifically on resuscitation fluid 1Read more

2025 08 Oct

For decades, progress in developing new treatments for critical illnesses such as sepsis, acute respiratory distress syndrome (ARDS), and trauma has been stalled by one fundamental challenge: although these conditions are treated as single diseases, every patient’s body responds differently. This heterogeneity has been a major barrier to advancing1Read more

2025 02 Oct

When a critically ill patient arrives in the emergency department, physicians must make rapid, high-stakes decisions related to infection and whether that infection is bacterial or viral. There are decisions related to whether the patient needs immediate treatment, and whether they can recover safely at home or must be admitted.    Even once1Read more

2025 13 Sep

  13 September is World Sepsis Day (WSD), a global movement uniting individuals, healthcare professionals, and organisations to confront one of the world’s deadliest yet most preventable conditions.   Since 2012, more than 54,000 stakeholders from 170 countries have joined together each year on 13 September to mark WSD. Participants inclu1Read more

2025 10 Sep

Vasopressors are standard therapy for sepsis-induced hypotension and shock, traditionally given via central venous catheters (CVCs) due to concerns about tissue injury from peripheral intravenous catheter (PIV) extravasation. Recent studies, however, suggest that peripheral vasopressors are safe, with low extravasation rates and minimal tissue inj1Read more

2025 04 Sep

Sepsis is a life-threatening, dysregulated immune response often leading to hypotension and multisystem organ dysfunction, with acute kidney injury (AKI) being the most common organ failure in critically ill patients. Traditional broad therapies for sepsis have largely failed due to the heterogeneity of the syndrome. Recent approaches focus on ide1Read more

2025 04 Sep

Sepsis remains a leading cause of ICU mortality, with therapeutic progress limited to infection control and supportive care, as molecularly targeted treatments have failed in clinical trials due to the syndrome’s heterogeneity. Personalised medicine requires accurate biomarkers and mechanistic insights, and mass spectrometry–based plasma proteom1Read more

2025 26 Aug

Sepsis, a life-threatening condition caused by a dysregulated response to infection, is linked to high in-hospital mortality and healthcare costs. Survivors face increased risks of hospital readmission, cardiovascular disease, cognitive impairment, and long-term healthcare expenses. While previous reviews have examined initial hospitalisation co1Read more

2025 20 Aug

Over 15,000 children experience in-hospital cardiac arrest (IHCA) annually in the U.S., with high mortality and common morbidity among survivors, despite advances in cardiopulmonary resuscitation (CPR) and resuscitation guidelines. IHCA in children is heterogeneous, often stemming from underlying diseases like sepsis, a frequent cause of critica1Read more

2025 14 Aug

Sepsis is a life-threatening condition marked by a dysregulated immune response, causing inflammation, tissue damage, and organ failure. It contributes to around 20% of global deaths and often leads to long-term impairments in survivors, known as post-sepsis syndrome (PSS), which can include physical, cognitive, and psychological symptoms such as 1Read more

2025 06 Aug

Sepsis is a severe condition causing widespread organ damage and failure, affecting multiple systems like cardiovascular, immune, and metabolic. Understanding of the mechanisms remains limited, hindering targeted treatments.   Metabolism, especially mitochondrial dysfunction, has emerged as a key factor in sepsis progression. Biomarkers like1Read more