Search Tag: Sepsis

ICU Management

Immunotherapy effects on sepsis

2019 01 May

A randomised controlled multicentre trial assessed for the first time the safety and pharmacokinetics of an antiprogrammed cell death-ligand 1 (anti–PD-L1) immune checkpoint inhibitor (BMS-936559; Bristol-Myers Squibb, Princeton, NJ) and its effect on immune biomarkers in participants with sepsis-associated immunosuppression. Results show that... Read more

ICU Management

New approach in managing patients with septic shock

2019 23 Apr

Sepsis remains the most common cause of vasodilatory shock worldwide. The mainstay of haemodynamic treatment of septic shock is fluid resuscitation followed by vasopressors where fluids alone are insufficient to achieve target blood pressure.  This article, published in the journal Critical Care, proposes the concept of “broad spectrum vasopressors”... Read more

ICU Management

Study: obesity improves short-term survival in sepsis

2019 16 Apr

In a large cohort study of 55,038 adults hospitalised with sepsis, short-term mortality (death or hospice) was lower in overweight and obese patients compared with those with normal body mass indices (both unadjusted and adjusted analyses). These findings highlight the need for well-conducted prospective clinical trials that assess obesity’s impact... Read more

ICU Management

#ISICEM19: Critical care medicine in space

2019 27 Mar

Dr. Matthieu Komorowski, Consultant in Intensive Care and Machine Learning researcher at Imperial College, London, talked about critical care in space at the 39th International Symposium on Intensive Care and Emergency Medicine .   One of the most distinct features about his talk (apart from the fact that it was about space), was that instead... Read more

ICU Management

Extravascular lung water as a target for intensive care

2019 14 Mar

The paper highlights the present clinical rationale for extravascular lung water measurement as a key to personalisation of haemodynamic therapy.   Introduction   Extravascular lung water (EVLW) remains a useful guide for monitoring pulmonary oedema (PO) and vascular permeability in sepsis, acute respiratory distress syndrome (ARDS),... Read more

ICU Management

Using biomarkers to improve sepsis diagnosis and treatment

2019 12 Mar

Since sepsis was first identified almost three decades ago, the existing definitions remain imprecise and the clinical diagnosis of sepsis corresponds poorly with post hoc presence of infection. Furthermore, the outcome of sepsis depends on factors beyond patient signs and symptoms, including age, the infection source, and the timing and appropriateness... Read more

ICU Management

The role of post-ICU recovery clinics

2019 06 Mar

With multiple advances in critical care, more patients are given the chance to survive life-threatening illnesses such as sepsis. This growing cohort of patients, however, grapples with a new challenge – post-intensive care syndrome (PICS). A raft of symptoms, including muscle weakness, depression, anxiety, and posttraumatic stress disorder (PTSD),... Read more

ICU Management

How preventable are in-hospital sepsis-associated deaths?

2019 20 Feb

In a cohort study reviewing the medical records of 568 patients who were admitted to six U.S. hospitals, sepsis was found to be the most common immediate cause of death. However, most underlying causes of death were related to severe chronic comorbidities and most sepsis-associated deaths were unlikely to be preventable through better hospital-based... Read more