Search Tag: Sepsis
Sepsis Through the Lens of Complexity Theory
2023 15 Mar
Sepsis is a complex and dysregulated state involving various factors, including pathogens, host response, organ failure, and medical interventions. Despite this complexity, the necessary concepts, approaches, and methods to understand sepsis are underappreciated. In a recent review, the authors highlight the need to understand sepsis through... Read more
Biomarkers in Sepsis
2023 13 Mar
This article describes the application of existing and emerging biomarkers in the diagnosis and management of sepsis and pneumonia. Introduction: The Need for Biomarkers in Sepsis Sepsis is defined as a dysregulated host response to infection that results in life threatening organ dysfunction. It carries an estimated... Read more
Biomarkers in Sepsis - Present and Future
2023 13 Mar
A biomarker defines a measurable indicator of a patient's medical situation that can be measured precisely and accurately. Biomarkers provide value for diagnosis, prognosis, early disease detection, risk stratification, suitable treatment (theragnostic), and trial improvement for patients with sepsis or presumed sepsis. Introduction... Read more
Tachycardia in Sepsis: Friend or Foe?
2023 13 Mar
An overview of tachycardia in sepsis, the importance of rate control and the beneficial effects of beta-blockers. Sepsis and Tachycardia – Aetiologic Factors During sepsis, the sympathetic nervous system plays a key role in maintaining cardiac output and blood pressure. This is achieved through changes in heart rate,... Read more
Antioxidant, Anti-inflammatory Therapy in Sepsis
2023 07 Mar
Sepsis is associated with long-term cognitive impairment and poor psychological and functional outcomes. Potential mechanisms for this include intracerebral oxidative stress and inflammation. However, there is limited knowledge about the effects of early antioxidant and anti-inflammatory therapy on cognitive, psychological, and functional outcomes... Read more
Sequential Extracorporeal Therapy in Sepsis
2023 15 Feb
Sepsis and septic shock are significant causes of morbidity and mortality in critical care, with a complex and rapidly evolving clinical presentation. This involves microbial invasion, infection focus, immune response, circulating pathogen and pathogen products, immunodysregulation, organ damage, and multiple organ dysfunction. Extracorporeal therapies... Read more
Nanofluidic Technology Enables Rapid Quantification of PSP as an Early Biomarker of Sepsis
2023 01 Feb
In-vitro diagnostic tests allow for quick results and prompt decision-making by medical professionals in near-patient settings. The abioSCOPE® device uses nanofluidic technology to quickly measure the number of molecules in a sample using a small amount of fluid and minimal preparation, resulting in fast results. Pancreatic stone protein (PSP) is a... Read more
Shifting Sepsis Quality Measures From Processes to Outcomes
2023 31 Jan
Sepsis is a significant health issue that leads to high rates of death and disability, with over 250,000 adult deaths annually in the U.S. alone. Healthcare providers, patients, regulatory agencies, and advocates for quality improvement acknowledge the importance of preventing sepsis and improving its outcomes. The Severe Sepsis/Septic Shock Early... Read more