Search Tag: Sepsis
2024 23 Jun
Sepsis can progress to multiple organ dysfunction syndrome or multiorgan failure. Globally, sepsis-related deaths are estimated at 11 million annually, representing 19.7% of total deaths, with a global age-standardised death rate of 148.1 per 100,000 people. Despite advancements in treatment, the case fatality rate for sepsis remains high at 30%...Read more
2024 23 Jun
A new study aimed to determine if continuous infusion of a β-lactam antibiotic (piperacillin-tazobactam or meropenem) reduces all-cause mortality at 90 days compared to intermittent infusion in critically ill patients with sepsis. The BLING III randomised clinical trial was conducted across 104 ICUs in Australia, Belgium, France, Malaysia,...Read more
2024 21 Jun
Patients with sepsis could be treated based on their immune system’s response to infection rather than their symptoms. New research has revealed that people’s genetic makeup significantly influences their response to sepsis. This understanding could help identify those who would benefit from specific treatments and pave the way for developing...Read more
2024 15 Jun
Sepsis is a life-threatening complication causing nearly 1.7 million hospitalisations and 350,000 deaths annually in the U.S. Rapid and accurate diagnosis is critical, as the risk of mortality increases by up to 8% for each hour that effective treatment is delayed. Currently, the diagnostic standard relies on culture growth, which typically takes...Read more
2024 13 Jun
A new study published in Microbiology Spectrum reveals that the nasal microbiota of ICU patients can effectively distinguish between sepsis and non-sepsis cases, outperforming gut microbiota in predicting sepsis. These findings have implications for developing diagnostic strategies and advancing critical care medicine. Historically, the focus...Read more
2024 04 Jun
Sepsis is a severe condition characterised by organ dysfunction due to impaired oxygen delivery and utilisation by cells. In ICUs, oxygen is often administered to sepsis patients, especially those with sepsis-induced hypoxaemic respiratory failure. Traditionally, the goal is to maintain a partial pressure of oxygen in arterial blood (PaO2) around...Read more
2024 01 Jun
Sepsis is a major cause of death and disability and a key focus of quality measures for hospitals. In-hospital mortality of sepsis patients is often used for benchmarking by researchers and policymakers. For instance, in New York, sepsis regulations require reporting risk-adjusted in-hospital mortality, identifying hospitals with higher or lower...Read more
2024 28 May
Sepsis causes 11 million deaths annually and is linked to post-intensive care syndrome (PICS), which includes physical impairment, reduced quality of life, and posttraumatic stress syndrome. Despite multidisciplinary interventions, up to 61.4% of sepsis patients experience physical impairment at hospital discharge. This is a significant outcome...Read more
2024 22 May
Acetaminophen (paracetamol) has several pharmacological effects that are potentially beneficial in sepsis, including analgesia, antipyresis, and cyclooxygenase-2 inhibition. Observational studies and small clinical trials suggest acetaminophen improves survival and kidney function in sepsis patients with elevated cell-free haemoglobin. However,...Read more
2024 16 May
Sepsis affects approximately 49 million people worldwide each year. To reduce the mortality rate and the global burden of sepsis, the World Health Organization has classified it as a priority research area. When combined with surgical trauma, anaesthetic drugs, and various invasive procedures, the impact intensifies, leading to further impairment...Read more
2024 14 May
Critical illness-related corticosteroid insufficiency (CIRCI) is commonly seen in criticall ill patients and involves systemic inflammation, hypothalamus–pituitary–adrenal axis dysregulation, altered cortisol metabolism, and tissue glucocorticoid resistance. A task force of international experts from the Society of Critical Care Medicine...Read more
2024 08 May
A recent study conducted by the University of Gothenburg involving over a million newborns in Sweden highlights a concerning trend: despite a notable decrease in the rate of sepsis among this group, the administration of antibiotics remains disproportionately high. The study, published in JAMA, highlights the need for a reevaluation of antibiotic...Read more
2024 30 Apr
A recent study investigates the clinical factors influencing clinician decisions regarding fluid administration, vasopressor initiation, and vasopressor route in early sepsis. Previous concerns about fluid overload in sepsis have prompted interest in early vasopressor initiation, especially through peripheral IVs, as an alternative to central lines....Read more
2024 21 Apr
Sepsis is a Medical Emergency Requiring Immediate Diagnosis & Treatment Pancreatic Stone Protein (PSP) on the abioSCOPE® is the Earliest Marker of Sepsis Sepsis is a major healthcare burden claiming more than 11 million lives per year, one death every 2.8 seconds 1 . It is caused by a dysregulated host response to infection which...Read more
2024 21 Apr
Sepsis is a Medical Emergency Requiring Immediate Diagnosis & Treatment Pancreatic Stone Protein (PSP) on the abioSCOPE® is the Earliest Marker of Sepsis Sepsis is a major healthcare burden claiming more than 11 million lives per year, one death every 2.8 seconds 1 . It is caused by a dysregulated host response to infection which...Read more
2024 02 Apr
A recent review explores the crucial role of hypoxia-inducible factor-1α (HIF-1α) in the development and progression of sepsis. Hypoxia-inducible factor (HIF) is a protein complex consisting of a constitutively expressed subunit β and an oxygen-dependent subunit α. HIF-1α is associated with acute hypoxia and regulates glycolytic genes, oxygen...Read more
2024 26 Mar
Sepsis remains a major cause of mortality, accounting for nearly 20% of global deaths. Microcirculatory dysfunction, marked by irregular blood flow and increased permeability of blood vessels, is a characteristic feature of sepsis. This dysfunction can lead to tissue swelling and impaired organ function. Endothelial dysfunction, which is also seen...Read more
2024 19 Mar
Findings presented at #ISICEM24 show that novel host transcriptomic signatures specific for bacterial and viral infection in children evaluated for sepsis can identify dysregulated host response leading to organ dysfunction. The goal of the study was to create gene expression signatures in children with bacterial or viral infections to predict...Read more
2024 12 Mar
An overview of landiolol, a potent and cardioselective beta-blocker offering a promising addition to the armamentarium for managing acute cardiac conditions for rapid and effective rate control with minimal adverse effects. Cardiac emergencies present complex challenges in emergency medical settings, requiring prompt and effective management...Read more
2024 28 Feb
Sepsis is characterised by dysregulated immune responses. Traditional approaches to treating sepsis by targeting proinflammatory and immunosuppressive responses have been largely unsuccessful. Recent efforts have shifted towards identifying subtypes of sepsis to enable personalised treatment. However, many important immunological concepts, such...Read more
2024 13 Feb
Early recognition and initiation of antibiotics are crucial in managing sepsis. Various warning scores, including qSOFA (quick Sequential Organ Failure Assessment), have been introduced to aid early detection. Patients with suspected infection and at least two of the qSOFA clinical signs are at a significantly higher risk of death after 28 days....Read more
2024 13 Feb
In a subgroup analysis of the Activated Protein C and Corticosteroids for Human Septic Shock (APROCCHSS) trial, researchers aimed to explore the effects of hydrocortisone plus fludrocortisone on patients with community-acquired pneumonia (CAP) compared to those with non-CAP-related septic shock. The goal was to determine whether glucocorticoids...Read more
2024 08 Feb
Nearly 1.7 million adults in the United States contract sepsis annually, with approximately 350,000 succumbing to the condition. In a recent study published in npj Digital Medicine, experts from the University of California San Diego School of Medicine harnessed an artificial intelligence (AI) model within the emergency departments of UC...Read more
2024 30 Jan
Sepsis, characterised by severe organ dysfunction, is a major cause of hospitalisation and mortality globally. The WHO recognises sepsis as a significant global health concern, urging efforts to enhance outcomes for affected individuals. Despite no new targeted therapies emerging for sepsis in recent decades, advancements in ICU management, shifts...Read more
2024 20 Mar
Session One March 20, 2024 | 3:00 PM EST Session Two March 28, 2024 | 1:00 PM EST Session Three March 26, 2024 | 11:00 AM GMT Read more
2024 23 Jan
In 2017, an estimated 25 million children worldwide experienced sepsis, resulting in over 3 million deaths. Paediatric sepsis survivors often face ongoing physical, cognitive, emotional, and psychological challenges. Children, particularly in lower-resource settings, face a higher risk of developing sepsis during their early years. The World Health...Read more
2024 16 Jan
Sepsis is a leading cause of hospital deaths. Despite initiatives like the Surviving Sepsis Campaign and Centers for Medicare & Medicaid Services Severe Sepsis and Septic Shock Management Bundle (SEP-1), healthcare disparities persist. Previous studies revealed disparities in sepsis outcomes by age, sex, race, and ethnicity, but limited English proficiency...Read more
2024 12 Jan
Sepsis is a prominent cause of mortality in ICUs. Despite extensive research on the dynamics leading to sepsis, the role of cytokines—immune system molecules that can cause substantial harm to the body—has remained inadequately understood. While these proteins typically regulate inflammation, an overly aggressive immune response can result in a cytokine...Read more
2024 03 Jan
This study focuses on the impact of sepsis, a condition resulting from a dysregulated immune response to infection, on the ability of patients to return to work (RTW). Sepsis is a significant global health concern, causing substantial morbidity and mortality. Sepsis survivors commonly experience long-term cognitive and functional impairments, but the...Read more
2023 30 Nov
Intensive care impacts more than the patient, with ripple effects for families, employers and wider societies. Patient-centred outcomes reiterate the need for clinical therapies targeting the biological circuitry of the big-hitting syndromes like ARDS, sepsis, delirium, renal failure and recognising they persist beyond the veil of discharge....Read more