Search Tag: Sepsis
2025 05 Nov
Sepsis remains one of the leading causes of death in intensive care units worldwide. Despite significant progress in early detection and management, antibiotic dosing protocols often fail to account for patient-specific factors, particularly those linked to biological sex and gender-related disparities in care. A new editorial in the Journal...Read more
2025 29 Oct
The European Society of Intensive Care Medicine (ESICM) convened an international panel of experts to develop evidence-based guidelines on fluid resuscitation volumes for adult critically ill patients with circulatory failure. This guideline represents Part 2 of a three-part series on fluid management, focusing specifically on resuscitation fluid volumes,...Read more
2025 08 Oct
For decades, progress in developing new treatments for critical illnesses such as sepsis, acute respiratory distress syndrome (ARDS), and trauma has been stalled by one fundamental challenge: although these conditions are treated as single diseases, every patient’s body responds differently. This heterogeneity has been a major barrier to advancing...Read more
2025 02 Oct
When a critically ill patient arrives in the emergency department, physicians must make rapid, high-stakes decisions related to infection and whether that infection is bacterial or viral. There are decisions related to whether the patient needs immediate treatment, and whether they can recover safely at home or must be admitted. Even once...Read more
2025 13 Sep
13 September is World Sepsis Day (WSD), a global movement uniting individuals, healthcare professionals, and organisations to confront one of the world’s deadliest yet most preventable conditions. Since 2012, more than 54,000 stakeholders from 170 countries have joined together each year on 13 September to mark WSD. Participants include...Read more
2025 10 Sep
Vasopressors are standard therapy for sepsis-induced hypotension and shock, traditionally given via central venous catheters (CVCs) due to concerns about tissue injury from peripheral intravenous catheter (PIV) extravasation. Recent studies, however, suggest that peripheral vasopressors are safe, with low extravasation rates and minimal tissue injury,...Read more
2025 04 Sep
Sepsis is a life-threatening, dysregulated immune response often leading to hypotension and multisystem organ dysfunction, with acute kidney injury (AKI) being the most common organ failure in critically ill patients. Traditional broad therapies for sepsis have largely failed due to the heterogeneity of the syndrome. Recent approaches focus on identifying...Read more
2025 04 Sep
Sepsis remains a leading cause of ICU mortality, with therapeutic progress limited to infection control and supportive care, as molecularly targeted treatments have failed in clinical trials due to the syndrome’s heterogeneity. Personalised medicine requires accurate biomarkers and mechanistic insights, and mass spectrometry–based plasma proteomics...Read more
2025 26 Aug
Sepsis, a life-threatening condition caused by a dysregulated response to infection, is linked to high in-hospital mortality and healthcare costs. Survivors face increased risks of hospital readmission, cardiovascular disease, cognitive impairment, and long-term healthcare expenses. While previous reviews have examined initial hospitalisation costs...Read more
2025 20 Aug
Over 15,000 children experience in-hospital cardiac arrest (IHCA) annually in the U.S., with high mortality and common morbidity among survivors, despite advances in cardiopulmonary resuscitation (CPR) and resuscitation guidelines. IHCA in children is heterogeneous, often stemming from underlying diseases like sepsis, a frequent cause of critical...Read more
2025 14 Aug
Sepsis is a life-threatening condition marked by a dysregulated immune response, causing inflammation, tissue damage, and organ failure. It contributes to around 20% of global deaths and often leads to long-term impairments in survivors, known as post-sepsis syndrome (PSS), which can include physical, cognitive, and psychological symptoms such as fatigue,...Read more
2025 06 Aug
Sepsis is a severe condition causing widespread organ damage and failure, affecting multiple systems like cardiovascular, immune, and metabolic. Understanding of the mechanisms remains limited, hindering targeted treatments. Metabolism, especially mitochondrial dysfunction, has emerged as a key factor in sepsis progression. Biomarkers like...Read more
2025 24 Jul
Sepsis remains a leading cause of morbidity and mortality in intensive care units (ICUs), exacerbated by delays in diagnosis and inadequate risk stratification. Despite advances in critical care, conventional biomarkers like procalcitonin (PCT) and C-reactive protein (CRP) often fail to provide timely or specific detection. Pancreatic Stone Protein...Read more
2025 15 Jul
Sepsis affects over 1.7 million people annually in the U.S., causing more than 350,000 deaths and over $62 billion in healthcare costs. The 2021 Surviving Sepsis Campaign (SSC) guidelines recommend antibiotic timing based on illness severity and sepsis probability, creating four risk categories, but this classification is subjective and often debated...Read more
2025 15 Jul
Many ICU survivors of sepsis do not fully regain health or normal function, facing issues in cognition, physical, and mental health (post-sepsis syndrome). Recovery, not just survival, is crucial to patients and families, but studies show increased healthcare use post-ICU , indicating incomplete recovery. Health, per WHO, includes physical, mental,...Read more
2025 25 Jun
Sepsis is a life-threatening condition caused by a dysregulated response to infection, leading to organ dysfunction and high mortality—about 10% overall and over 40% in septic shock cases. Early detection of patients at risk of deterioration in the emergency department (ED) is critical for timely treatment and appropriate patient disposition. Existing...Read more
2025 11 Jun
Sepsis is a life-threatening condition that affects approximately 750,000 people annually in the U.S., with a mortality rate of around 27%. In about 15% of these cases, sepsis progresses to septic shock, a more severe state marked by dangerously low blood pressure and reduced tissue perfusion, where the risk of death increases to 30-40%. Prompt...Read more
2025 03 Jun
Sepsis is a serious global health issue, with septic shock carrying a high mortality rate (~38.5%). The optimal blood pressure target for managing septic shock remains unclear. Recent trials show that maintaining a mean arterial pressure (MAP) above 65 mmHg isn’t always beneficial, but higher targets (80–85 mmHg) may help patients with chronic hypertension....Read more
2025 20 May
Sepsis remains one of the most daunting challenges in critical care. An estimated 49 million cases of sepsis occur globally every year, and it affects 1 in 5 people worldwide. Sepsis is responsible for 11 million deaths each year — this accounts for 20% of all global deaths. Sepsis and Acute Respiratory Distress Syndrome (ARDS)...Read more
2025 20 May
Sepsis and Acute Respiratory Distress Syndrome (ARDS) are heterogeneous critical illness syndromes. Molecular subphenotyping shows promise in furthering our understanding of these syndromes and may offer a more precise method for identifying appropriate therapies. Current Definitions of Sepsis and Acute Respiratory Distress Syndrome...Read more
2025 20 May
Both sepsis and Acute Respiratory Distress Syndrome (ARDS) are major determinants of morbidity and mortality in the ICU, and sepsis is often complicated by ARDS. We discuss the role of corticosteroids in these patients. Introduction Acute respiratory distress syndrome (ARDS) is a heterogeneous syndrome that can be the result of several...Read more
2025 20 May
This article highlights sepsis early recognition and prevention to reduce the risk of developing sepsis-induced ARDS while emphasising pathophysiology, early recognition, and early intervention for both conditions. Introduction Sepsis, a life-threatening condition caused by a dysregulated immune response to infection, is a preventable...Read more
2025 20 May
Sepsis-induced ARDS is a critical condition that may require anti-inflammatory strategies. There are some promising treatments that may alter the evolution, including corticosteroids, vitamin C, NET inhibitors, and statins, which help mitigate excessive immune response and improve clinical outcomes. Introduction Sepsis represents a...Read more
2025 20 May
Sepsis and ARDS are complex syndromes where point-of-care testing and biomarker-guided, personalised treatments offer growing promise. With high mortality, prolonged recovery, and emerging therapies like anti-fibrotics, even small gains may be cost-effective. Sepsis and Acute Respiratory Distress Syndrome (ARDS) are both clinical syndromes...Read more
2025 28 Apr
Sepsis and septic shock represent critical conditions frequently encountered in emergency medicine, carrying significant risks of morbidity and mortality. Vitamin C has been proposed as a potential therapeutic agent due to its antioxidant, anti-inflammatory, and immunomodulatory properties. The C-EASIE trial was conducted to evaluate whether...Read more
2025 15 Apr
Sepsis remains a major cause of illness and death among children worldwide. Although mortality has decreased due to quality improvement initiatives and clinical guidelines, 4–10% of paediatric sepsis cases still result in death, often due to refractory shock or multiorgan dysfunction. For children with persistent shock despite fluid resuscitation,...Read more
2025 03 Apr
Sepsis remains a major global health issue, with nearly 49 million cases and 11 million deaths annually. International guidelines emphasise routine screening and standardised treatment protocols for high-risk patients. The World Health Assembly’s 2017 Resolution 70.7 and the G7 Health Ministers’ 2022 statement have called for enhanced prevention, diagnosis,...Read more
2025 27 Mar
The basics of vasopressor support and advanced considerations regarding its early use in intensive care settings. Introduction The use of vasopressors in critical care is a crucial aspect of haemodynamic management. While norepinephrine remains the primary agent of choice, the role of other vasopressors such as vasopressin has gained...Read more