• Introduction to Landiolol in Acute Cardiac Care

      An overview of landiolol, a potent and cardioselective beta-blocker offering a promising addition to the armamentarium for managing acute cardiac conditions for rapid and effective rate control with minimal adverse effects.   Cardiac emergencies present complex challenges in emergency medical settings, requiring prompt and effective management...

  • Cardiovascular Management in Septic Shock: Optimising Vascular and Cardiac Function

    An overview of vasopressor management, current evidence on its use, when to initiate vasopressor therapy for best possible patient outcome and a discussion regarding the use of landiolol in septic patients with persistent tachycardia.    Optimising Vasopressin Initiation in Septic Shock   Patients with septic shock, and especially...

  • Cardiovascular Management in Sepsis: Improving Cardiac and Vascular Functions

    Vasopressin and landiolol are critical therapies for ensuring the vascular and cardiac systems are as close to optimal conditions as possible during septic shock. Better cardiovascular management in septic shock can help improve septic shock management.     Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response...

  • Neonatal Extracorporeal Membrane Oxygenation

    Xenios sponsored a lunch symposium at the 16th European Conference on Paediatric and Neonatal Ventilation (EPNV) in Montreux (CH) in May 2023. Matteo Di Nardo (Italy) introduced the audience to extracorporeal membrane oxygenation (ECMO) in neonates. Florian Kipfmüller (Germany) presented current knowledge and his experience with ECMO in neonates...

  • Using iMg Testing for Clinical Management in the ICU

    An overview of ionised serum magnesium as an important biomarker for critically ill patients and how iMg testing is utilised at Mater Intensive Care.     Ionised Serum Magnesium - An Important Biomarker Magnesium is the fourth most common cation in the body and the second most abundant intracellular cation, exceeded only by potassium....

  • Applying International Sepsis Guidelines by Screening High-Risk Hospitalised Patients With PSP

    Hospital and ICU nosocomial sepsis screening for acutely ill and high-risk patients and daily measurement of PSP to diagnose nosocomial sepsis three to five days before the onset of symptoms.     Introduction Sepsis is a major public health threat and is responsible for 11 million deaths per year (Rudd et al. 2020) among 48.9 million cases....

  • Biomarkers as Prognostic Predictors and Guide in Critically Ill Patients

    An overview of promising biomarkers in critical care, characteristics a biomarker should have and how to ensure their usefulness in clinical practice.   Introduction   Precision medicine is a medical approach that tailors treatments based on individual patient characteristics and their unique response to therapies for a particular disease....

  • Detecting Euglycaemic Diabetic Ketoacidosis Associated With SGLT2 Inhibitors

    SGLT2 inhibitor associated EDKA is becoming more prevalent due to the increasing use of SGLT2 inhibitors in cardiovascular medicine and type 2 diabetes. Physician awareness and knowledge about the disease and diagnostic tools need to improve for better management. Point of care blood testing for ketones can allow for rapid and accurate diagnosis....

  • Sepsis Diagnosis: Clinical Signs, Scores, and Biomarkers

    Abstract     Sepsis and antimicrobial resistance are two major public health problems . Sepsis is defined as a dysregulated response of the body to a bacterial infection with organ dysfunction . The 2021 Surviving Sepsis Campaign SSC guidelines proposed characterising the infection based on clinical assessment and the dysregulated...

  • Sepsis Diagnosis: Pancreatic Stone Protein in Adults, Children, and Neonates

    Based on the concepts and the checklist criteria for an ideal sepsis biomarker presented in the article Sepsis Diagnosis: Clinical signs, Scores, and Biomarkers in this issue of ICU Management & Practice , we update and review the potential use of Pancreatic Stone Protein (PSP) in adults, children, and neonates.     Pancreatic Stone...

  • Tachycardia in Sepsis: Friend or Foe?

    An overview of tachycardia in sepsis, the importance of rate control and the beneficial effects of beta-blockers.         Sepsis and Tachycardia – Aetiologic Factors During sepsis, the sympathetic nervous system plays a key role in maintaining cardiac output and blood pressure. This is achieved through changes...

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