Point-of-View

Hypotension during septic shock is a strong indicator of patient outcome and mortality. Arginine vasopressin is a naturally produced human hormone with vasoconstriction effect via V1 receptor activation and a short 5-20 minutes half-life and is recommended by the Surviving Sepsis Campaign guidelines to be added as a second-line vasoactive agent when increasing mean arterial pressure with norepinephrine alon

Dr Fernando Chaves

Dr Fernando Chaves

The laboratory plays a critical role in ensuring optimal outcomes for ICU patients. Several biomarkers are valuable in this context and can help clinicians achieve improved patient outcomes and decreased expenses for healthcare. Improving both in-ICU and post-ICU clinical outcomes often depends on actions taken much sooner in a patient’s pathway during hospitalisation. Regardless of the underlying diag

 Salvatore Lucio Cutuli

Salvatore Lucio Cutuli

An overview of the clinical application and future perspective of the Seraph® 100 haemoperfusion in critically ill patients with sepsis. Background Over the last few decades, sepsis has been spreading worldwide to such an extent that it has been declared global health priority by the World Health Organization (Reinhart et al. 2017). Sepsis is an old disease (Cutuli et al. 2017) and many efforts have been

Prof. Michael Mansour, MD, PhD, FIDSA, FECMM

Prof. Michael Mansour, MD, PhD, FIDSA, FECMM

Professor Michael Mansour is a physician-scientist with a research concentration in immune responses against invading pathogens. He attends on the Clinical Transplant Infectious Diseases and Immunocompromised Host Service at the Massachusetts General Hospital - Division of Infectious Diseases, where he cares for solid and stem cell transplant recipients and individuals with weakened immunity. He also direc

Dr Herwig Gerlach

Dr Herwig Gerlach

Sepsis and septic shock are the leading causes of death in the ICU. With an estimated mortality rate of 40-60%, septic shock is in the focus of adult critical care medicine. It is broadly accepted that intervention in the very early phase of sepsis before the complex inflammatory host response is initiated should be one major area that clinical research should focus on. Introduction Currently, sepsis and

COVID-19 affects the myocardium and myocarditis and cardiac injury is a common condition among hospitalised patients. Landiolol, a new ultra-short acting, intravenous most β1 selective blocker, can help reduce inflammation and provide therapeutic benefits. Influenza, bacterial pneumonias, respiratory infections and viruses are well-established factors that cause cardiovascular disease (CVD) and are asso

An overview of the Surviving Sepsis Guidelines for the vasoactive agent management of COVID-19 patients with septic shock and the use of arginine vasopressin in this patient population. The SARS-CoV-2 has caused a global health crisis. Thousands of people across the globe have been affected by COVID-19. Clinicians are in urgent need of guidance and recommendations to treat patients and improve outcomes.

Dr. Jorge Ibrain Figueira Salluh, MD, PhD

Dr. Jorge Ibrain Figueira Salluh, MD, PhD

In this article, we focus on clinical and practical application of current available cloud-based data analysis to track and benchmark in real-time suspect and confirmed COVID-19 cases, resource use and availability. Introduction The COVID-19 pandemic represents an unprecedented challenge to intensive care units (ICU) due to the surge of severe cases of pneumonia posing great stress to hospitals and healt

Acute Kidney Injury (AKI) develops in over 55% of ICU patients patients (Hoste et al. 2015). As infections and the need for mechanical ventilation are known to be among the high-risk factors for the development of AKI (Bellomo et al. 2017), the incidence may be even higher in the COVID-19 era. For ICU patients with COVID-19 or other complex conditions, essential physiological functions such as cardiac ou

Dr. Jürgen Fortin

Dr. Jürgen Fortin

The rapid global distribution of COVID-19 is challenging healthcare systems worldwide. In many countries hospitals and ICU departments are overloaded or fear a potential collapse - the optimal allocation of healthcare resources is required. Healthcare professionals are forced to treat severely ill patients with limited access to ventilation equipment, qualified intensive care personnel or protective patien

 Pau Sarsanedas

Pau Sarsanedas

One of the major problems for hospitals fighting the COVID-19 pandemic has been the lack of emergency ventilation devices. GPAINNOVA, a multinational company from Spain, has a simple and efficient solution to this – RESPIRA. Novel Approach RESPIRA is an ICU ventilator based on AMBU automation for assisted ventilation. It has been designed specifically for the needs of intensive care doctors involved in

Baxter launches a new parenteral nutrition formulation designed to meet the need for higher protein provision in Europe and signs a global partnership with COSMED to commercialise Q-NRG+, a metabolic monitoring device that utilises indirect calorimetry technology. Malnutrition in the ICU Around 20 to 50% of hospital patients, including those in the ICU (trauma, surgery) are malnourished.1 Malnutrition is

 Walter Habenbacher

Walter Habenbacher

How effective are less invasive or even noninvasive methods? The clinical and economic burden of post-surgical complications and the economic impact of Goal-Directed Fluid Therapy (GDFT) implementation. Improving the quality of care by reducing post-surgical complications, decreasing mortality, and decreasing hospital length-of-stay for surgical patients while also redu

Dr. Claire Thomas

Dr. Claire Thomas

Accelerate, Accelerate Pheno system, sepsis

Our clinical experiences of using the Accelerate Pheno™ system have greatly benefited patient care, providing earlier diagnostic certainty. Two complex sepsis cases are discussed, where the impact of rapid identification, with antibiotic sensitivities, of the causative organism from blood cultures is described. At Hampshire Hospitals NHS Foundation Trust, we endeavour to be ahead of the curve in diagno

Dr. Nieves Larrosa, MD, PhD

Dr. Nieves Larrosa, MD, PhD

Describes an episode of sepsis in a leukaemia patient, whose treatment was early guided by using rapid diagnostics technology to identify the cause of infection. A 4-year-old patient under treatment for acute lymphoblastic leukaemia, diagnosed 6 months before, was admitted to the emergency room (ER) at midnight (00h33) due to a fever episode of less than one hour of evolution in the context of neutropaen

Dr. Ricard Ferrer, MD, PhD

Dr. Ricard Ferrer, MD, PhD

Sepsis

Implementation of a sepsis code, Código Sepsis, in October 2015 at the Vall d’Hebron University Hospital in Barcelona has led to better detection and a significant reduction in mortality. The hospital is the largest in Barcelona, with more than 1,100 beds and 7,000 employees. The objectives of Código Sepsis are to increase suspicion of sepsis and septic shock, improve the early administration of initia

Dr. Karin Becke, MD

Dr. Karin Becke, MD

Paediatric Sedation,Primex Pharmaceuticals ,Symposium

Report of the Primex Pharmaceuticals Symposium, Euroanaesthesia 2017, Geneva, Switzerland, 4 June 2017 Current treatment options and challenges - Dr. K. Becke Background An increasing number of diagnostic and treatment procedures are performed outside the operating room. Without sedation even minor procedures such as vaccination can be painful, stressful and lead to severe trauma. Sedation ensure

Prof. Gian Maria Rossolini

Prof. Gian Maria Rossolini

MIC Evaluation,n Antimicrobial Stewardship

Dealing with Antimicrobial Resistance Recently antibiotic resistance has become a major public health issue with global dimensions, having a remarkable impact on morbidity, mortality and healthcare associated costs. Due to its increasing relevance, the “antibiotic resistance crisis” has entered the agenda of the WHO and other international agencies, scientific societies, governments and even the UN

Dr Gavin Troughton

Dr Gavin Troughton

Glycaemic Control Practice

Elevated blood glucose is a widely recognised response to critical illness, with most non-diabetic patients exhibiting concentrations outside the normoglycaemic range and a substantial proportion having significantly or hugely elevated blood levels (Farrokhi et al. 2011). It has been 15 years since the publication of the Leuven study abruptly changed the landscape of glycaemic control, highlighting the tol

 Phil Weihser

Phil Weihser

point-of-care, emergency department

Many patients presenting to the hospital ‏emergency department do not need ‏to stay overnight. Ambulatory emergency ‏care (AEC) may optimise identification ‏and management of such patients by delivering ‏streamlined, efficient patient care within ‏one working day. This may improve clinical ‏outcomes, patient experience and lower costs. At James Paget University Hospital, the acute ‏medi

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