Insulin Resistance Increases Risk for Alzheimer's Disease
Insulin resistance, broadly defined as reduced tissue responsiveness to the action of insulin, is common in people who are obese, prediabetic or have Type 2 diabetes. Insulin has been increasingly recognised as playing an important role in the brain, according to the study background.
Barbara B. Bendlin, PhD, of the University of Wisconsin School of Medicine and Public Health, and colleagues examined 150 cognitively normal, late middle-age adults (average age nearly 61) from the Wisconsin Registry for Alzheimer’s Prevention (WRAP) study, a general community sample enriched for AD parental history. The subjects underwent cognitive testing, a fasting blood draw and fludeoxyglucose F 18-labelled positron emission tomography (PET) of the brain.
Of the 150 participants, 108 (72 percent) were women, 103 (68.7 percent) had a parental history of AD, 61 (40.7 percent) had an APOE ε4 allele and seven (4.7 percent) had type 2 diabetes.
Dr. Bendlin's team found that insulin resistance was associated with lower global glucose metabolism and lower regional glucose metabolism across large portions of the brain in the frontal, lateral, parietal, lateral temporal and medial temporal lobes. Lower glucose metabolism in the left medial temporal lobe was related to worse performance in immediate memory, according to researchers.
The study is the first to look at insulin resistance in late middle-aged people, identify a pattern of decreased blood sugar use related to AD and link that to memory decline.
“The prevalence of AD continues to grow, and midlife may be a critical period for initiating treatments aimed at preventing or delaying the onset of AD. Accumulating evidence suggests that treatments targeting mechanisms involved in insulin signalling may affect central glucose metabolism and should be investigated in the context of presymptomatic AD,” the authors conclude.
Image credit: Flickr.com
Published on : Tue, 28 Jul 2015
Print as PDF
Based on Mindray's new generation ultrasound platform, mQuadro, M9 has raised the industry standards to an all new level. Advanced signal transmission and reception processors provide highly sensitive and accurate echo detection. Innovative transducer...
The TE7 touch screen ultrasound system is designed to provide superior quality imaging for rapid patient-care decisions. Intuitive gesture controls and efficient focused point-of-care exams minimize the user learning curve, with no need to navigate a...
Introducing a new chapter in ultrasound visualization technology. X-Porte was developed from the ground up to incorporate a breakthrough, proprietary beam-forming technology: XDI (Extreme Definition Imaging). This signal analysis algorithm shapes X-Porte's...
We recognize that the best chance any patient has at getting better is a clinician at their bedside with all the right answers and the confidence to act. SonoSite education and training is the industry standard – no other point-of-care ultrasound manufacturer...
Due to the complex nature of the spine, surgeries may be particularly difficult and call for careful preparation for better outcomes. The spineEOS online software provides a 3D visualization of the patient’s spine in its current state as well as a literature-based,...