Old Blood as Good as Fresh
A team of researchers from 64 Canadian and European centres conducted the Age of Blood Evaluation (ABLE) study, a randomised double-blind trial to compare mortality after 90 days in intensive care patients transfused with either fresh blood (stored for an average of six days) or older blood (stored for an average of 22 days). The study covered 2,430 adults, including 1,211 patients in the fresh blood group and 1,219 in the older blood group.
Study results showed that 423 patients died within 90 days post-transfusion in the group of patients who received fresh blood, compared to 398 patients who died in the group that received older blood.
“There was no difference in mortality or organ dysfunction between the two groups, which means that fresh blood is not better than older blood”, explains Dr. Dean Fergusson, a senior scientist at the Ottawa Hospital Research Institute and the University of Ottawa.
According to current standards, blood is stored up to 42 days. However, many doctors have begun to ask for fresh blood in recent decades, thinking that it is the right thing to do. This is made difficult because of a limited supply and because blood collection agencies and hospital blood banks distribute blood on a “first-in, first-out” basis to avoid wastage.
“Current blood bank practice is to provide patients with the oldest blood available. Some doctors, however, feel that fresh blood is better”, says Dr. Paul Hébert, an intensive care physician-scientist at the Centre de Recherche du CHUM and professor at the Université de Montréal.
As Dr. Alan Tinmouth, a physician and scientist at the Ottawa Hospital Research Institute and the University of Ottawa, points out: “Previous observational and laboratory studies have suggested that fresh blood may be better because of the breakdown of red blood cells and accumulation of toxins during storage. But this definitive clinical trial clearly shows that these changes do not affect the quality of blood.”
Blood transfusions save lives, affirm the researchers. "There is no need to worry about the safety of the age of blood routinely used in hospitals," they add.
The same research team is conducting a clinical trial in paediatric patients. “This study should verify whether children react to fresh blood and older blood transfusions in the same way as adults”, says Dr. Jacques Lacroix of Sainte-Justine University Hospital Research Center and professor at the Université de Montréal.
Source: Universite de Montreal
Image Credit: Centre de Recherche du CHUM
Published on : Tue, 17 Mar 2015
Print as PDF
The fully featured ICU ventilator, HAMILTON-MR1, guarantees uncompromised continuous ventilation care from the ICU to the MRI scanner and back. Its reliability and high performance, with advanced lung-protective strategies and patient-adaptive modes,...
Monitor vital signs of sensitive patients with reliable, smart and intuitive technology Not available in the US Sensitive patients, like neonates, require comfortable care. With transcutaneous monitoring, you can easily keep track of the oxygenation...
The HAMILTON-C3 ventilator is a modular high-end ventilation solution for all patient groups. Offering a number of unique features, the HAMILTON-C3 is one of the first ventilators featuring the “Ventilation Autopilot” INTELLiVENT-ASV®. The HAMILTON-C3’s...
NovaPort cannulas: The safe access to the vascular system. NovaPort® twin double lumen cannulas are specifically developed for veno-venous vascular access. NovaPort one single lumen cannulas are specifically developed for the percutaneous connection (KU)...
The HAMILTON-C1 neo is a versatile neonatal ventilator that combines invasive and noninvasive modes with the additional options of nCPAP and high flow oxygen therapy. The integrated turbine allows it to be operated independently of a compressed air supply....