How Prevalent is Systemic Inflammation after Critical Illness?
The reviewers, led by David M. Griffith, MD, from the Department of Anaesthesia, Critical Care and Pain Medicine, Edinburgh Medical School, University of Edinburgh, UK, reviewed 22 studies of ICU patients aged over 16, who had a clinical or biochemical marker of systemic inflammation measured, and included publications up to December 2011.
See Also: Possible Cause for Chronic Muscle Dysfunction after ICU
The reviewers note that the considerable heterogeneity of the study populations under study and high risk of selection bias precluded meta-analysis. They conclude that the available data do not appear to address the key question of inflammatory mediation of functional recovery, as no studies have reported correlations between inflammatory biomarkers and physical recovery outcomes. They add that the review provides initial evidence that the exposure of interest is present in the early post-ICU period but highlights the need for research into the key processes involved as the patient transitions into the community.
“This may allow us to better identify patients likely to experience a poor recovery trajectory to specifically target physical interventions and potentially to identify processes that might be amenable to pharmacological intervention. It is hoped that these together will improve functional recovery for ICU survivors in the future”, they write.
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Published on : Mon, 25 Apr 2016
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