• Pathophysiology of endotoxic shock

    Mechanisms of endotoxin-induced multi-organ damage. Endotoxin-induced sepsis remains a leading cause of mortality in intensive care units (ICUs) worldwide. Lipopolysaccharide (LPS) identification by the immune system triggers a cascade of signalling pathways, leading to the release of several cytokines and chemokines, which orchestrate the...

    READ MORE
  • What’s new in sepsis in children?

    The latest in diagnosis and treatment. Sepsis is a life-threatening condition in children. Current paediatric definitions are based on systemic inflammatory response syndrome. Since the publication of the third international consensus definitions for sepsis and septic shock for adults, efforts in paediatrics are focused on finding a definition...

    READ MORE
  • Improving access to safe anaesthesia

    Interview with Jannicke Mellin-Olsen, President, World Federation of Societies of Anaesthesiologists. Jannicke Mellin-Olsen, MD, DPH is Consultant Anaesthesiologist at the Department of Anaesthesia, Intensive Care and Emergency Medicine, Bærum Hospital, Norway. She is President of the World Federation of Societies of Anaesthesiologists, and...

    READ MORE
  • Evidence for using first-line coagulation factor concentrates for trauma- induced coagulopathy

    Fibrinogen limits coagulopathy and massive bleeding, has less transfusion requirements and thereby decreases the risk of multi-organ failure in trauma patients. What stops the bleeding? Haemostatic therapy aims to stop the bleeding, but is it a concentration of coagulation factors, mainly assessed by international normalised ratio (INR)...

    READ MORE
  • Implementation of a revised trauma management protocol

    Goal-directed therapy of coagulopathy is recommended for trauma patients. Can guidelines direct our strategy? When presented with bleeding trauma patients, our management strategy may be directed by guidelines, e.g. the European trauma guideline (Rossaint et al. 2016). This recommends treatment with fibrinogen concentrate or cryoprecipitate...

    READ MORE
  • img

    EMERGE10

    EMERGE10

    READ MORE
  • img

    ESA Focus Meeting 2018

    ESA Focus Meeting 2018

    READ MORE
  • img

    Sink traps source of antibiotic-resistant bacteria in ICU

    • ICU
    • 10/10/2018

    Carbapenemase Producing Enterobacteriaceae (CPE) are bacteria or "bugs", and CPE outbreaks are mostly attributed to patient-to-patient transmission

    READ MORE
  • img

    Managing invasive fungal infections

    • ICU
    • 10/10/2018

    New research provides insights into antifungal utilisation within U.S. academic medical centres (AMCs) in the neonatal, paediatric, and adult...

    READ MORE
  • img

    Quality of life after discharge from an ICU

    • ICU
    • 10/10/2018

    Quality of life (QoL) after critical illness is becoming increasingly important as survival improves. A systematic review, conducted by University...

    READ MORE
Subscribe To The ICU Management Channel