- BRAF+MEK inhibitor therapy was associated with a higher risk ratio of pulmonary embolism, decrease in LVEF, and arterial hypertension compared with BRAF inhibitor monotherapy.
- BRAF+MEK inhibitor therapy was not associated with higher rates of myocardial infarction, atrial fibrillation, or QTc interval prolongation compared with BRAF inhibitor monotherapy.
- The risk ratio of high-grade decrease in LVEF and high-grade arterial hypertension were higher in the BRAF+MEK inhibitor group compared to the BRAF inhibitor monotherapy group.
- A higher risk of a decrease in LVEF was associated with patients with a mean age younger than 55 years.
- BRAF+MEK inhibitor therapy was associated with a higher risk of pulmonary embolism.
Cardiovascular Adverse Events After Treatment With BRAF and MEK Inhibitors
Published on : Mon, 19 Aug 2019
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