Search Tag: cardiovascular adverse effects

Cardiovascular Adverse Events After Treatment With BRAF and MEK Inhibitors

2019 19 Aug

Melanoma accounts for nearly 55500 cancer deaths annually worldwide. Most mutations in melanoma occur at the level of BRAF with an upregulation of the MAPK pathway. BRAF mutations prompted the development of BRAF inhibitors which cause resistance through a signalling cascade mediated by MEK. This, in turn, led to the development of MEK inhibitor... Read more