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Microbiome in Sepsis and COVID-19
Bacteria play a fundamental role in human life. Given the many roles of gut microbiota in critical illness and other pathological conditions, it is important to target therapeutical interventions to restore, preserve and enrich its composition. Introduction Bacteria play, for better or worse, a fundamental role in human life. As...
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The Intestinal Microbiome in Critical Illness
Critical illness alters the intestinal microbiome, resulting in a loss of microbial diversity and induction of a pathobiome. Manipulating the intestinal microbiome offers a potential treatment approach in ICU patients. T he intestinal microbiome is comprised of diverse, robust microbial communities within the intestine, modified by...
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Microbiome and Probiotics: Do They Really Work?
The microbiota is recognised as one of the most important factors that can worsen the clinical conditions of patients who are already very frail in the intensive care unit. It also plays a crucial role in the prevention of ICU associated complications. It’s important to ensure the best functioning of the intestinal immune system. T...
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Clostridioides difficile Infection: Complication of Intestinal Microbiome Alteration
Clostridioides difficile (C. difficile) infection is a potentially serious complication in critical patients admitted to the Intensive Care Unit (ICU). It generally occurs because of an alteration of the intestinal microbiota due to antibiotic exposure that must be timely identified and diagnosed to start proper and early management....
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The Role of the Microbiome and Nutritional Therapy in Critical COVID-19
Dysbiosis has been closely related to inflammation and severe-to-critical COVID-19, a reason why nutritional therapy could be important in the prevention and management of critical disease. Introduction Infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease (COVID-19), involves...
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Methylene Blue for Vasoplegic Syndrome Post Cardiac Surgery
Post-operative cardiac surgical patients are encountered commonly in the intensive care unit. Methylene blue might be a useful treatment for patients with vasopressor-refractory vasoplegia but high quality evidence is lacking. C ardiac surgery is one of the most frequently performed major surgical procedures, with more than 1 million operations...
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Management of Acute Arrhythmias in Patients With Cardiac Dysfunction - Update of ESC Guidelines
In 2020, the ultra-short acting beta-blocker landiolol was first included in the ESC guidelines with a class I recommendation. The recommendations were based on study results demonstrating the rapid response, efficacy, and safety of this drug. At a recent symposium, during 2021 Heart Failure World Congress, cardiologists were invited to present...
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Mitigating the Risk of Harm During the Transition From Controlled to Assisted Mechanical Ventilation
Monitoring the strength of the patient´s breathing effort, titrating the sedation, and selecting the correct mode of ventilation is vital when transitioning from controlled to assisted ventilation. Assessing The Transition From Fully Controlled to Assisted Ventilation One of the key issues with mechanical ventilation is the transition...
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Health and the City
The COVID-19 pandemic has made it abundantly clear that healthcare systems worldwide need significant transformation and change. There is an urgent need for new models of care to improve patient outcomes and be better prepared for future health crises similar to the recent pandemic. With the increasing prevalence of chronic disease and a...
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