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Department of Critical Care Imperial College Healthcare NHS Trust St Mary’s Hospital
Heparin-induced thrombocytopaenia (HIT) is an immune complication of heparin therapy. This review discusses the pathophysiology, incidence, clinical manifestations, diagnostic approach, and management of patients with HIT. Pathophysiology HIT is an immune complication of heparin therapy caused by IgG antibodies to complexes of platelet factor 4 (PF4) and heparin. These antibodies bind...
READ MOREAnaemia is commonly encountered in the critically ill and is associated with poor outcomes. The cause is multifactorial and includes high hepcidin levels and a blunted response to erythropoietin. A naemia is defined by haemoglobin (Hb) < 12 g/dL for women and Hb below 13 g/dL for men, according to the WHO (1968). Anaemia is a prevalent condition that affects nearly all critically ill...
READ MOREThe lack of non-technical skills is associated with poor performance and patient harm in medicine. H uman Factor (HF) is an established scientific discipline that studies the interrelationship between humans, equipment, and work environment. Core aspects of HF, widely known as non-technical skills (NTS), include three dimensions 1) cognitive (situation awareness, decision making),...
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