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Anaesthetic Registrar North Bristol NHS Trust
One of the many facets of critical illness is myopathy, which is associated with increased morbidity and mortality. Here, we delve into the metabolic drivers of muscle wasting, its overlap with frailty syndromes, and how insights into the pathways involved may unveil potential therapeutic strategies. Critical care reflects gruelling illness. Medium to long-term outcomes also reflect a1
READ MORESepsis and ARDS are complex syndromes where point-of-care testing and biomarker-guided, personalised treatments offer growing promise. With high mortality, prolonged recovery, and emerging therapies like anti-fibrotics, even small gains may be cost-effective. Sepsis and Acute Respiratory Distress Syndrome (ARDS) are both clinical syndromes with a high mortality and morbidity burden1
READ MOREIntensive care impacts more than the patient, with ripple effects for families, employers and wider societies. Patient-centred outcomes reiterate the need for clinical therapies targeting the biological circuitry of the big-hitting syndromes like ARDS, sepsis, delirium, renal failure and recognising they persist beyond the veil of discharge. Co-author Lucas Alvarez Belon Ac1
READ MOREBiomarkers hint at the pathophysiology behind a clinical entity, leading to better treatments. Access to biomarker testing may improve drug discovery in clinical trials, responses at the bedside and personalised patient management. The human body is a construct of chemical fires – each with a characteristic smoke signal. The smoke signals are borne to the clinician in the form of biom1
READ MOREBiomarkers are quantifiable indicators of physiological or pathological processes in the body. They can be more effectively utilised in intensive care by improving standardised protocols for biomarker testing and interpretation. Join our panellists as they discuss the use of Biomarkers in critical care and where and how biomarkers can provide valuable diagnostic, prognostic and therapeutic valu1
READ MOREAn overview of hyperoxia, effect of reactive oxygen species on biological processes and tissues and effective strategies for oxygen therapy. The reliance of life on oxygen is a modern and terra-centric view. Oxygen only appeared on the scene about 450 million years ago – wiping out many life forms or forcing them to trap oxygen with porphyrin rings – the ancestor of our own haemog1
READ MOREAn article exploring the experience of an intensive care registrar overnight and the evidence supporting admissions, fatigue, judgement and morality in the circadian cycle. A t night, ICU feels like a fortress that has been put to bed for the night, and as a registrar, you have a role blended from sentinel, secretary, detective and a Valkyrie. Crenelated walls of beds ju1
READ MOREHow are we dealing with the COVID-19 pandemic and the lessons we can learn from similar diseases over the last few centuries. The face of human history has always been pockmarked by disease, in more ways than one. In our current privileged world of technology, gene sequencing and micro RNA, the possibility of a new disease that kept us inside our houses seemed an impossible dystopia. How1
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