Search Tag: subphenotypes

2024 17 Jul

  Critical care has traditionally focused on clinical practice and research around syndromes such as sepsis, acute respiratory distress syndrome (ARDS), acute kidney injury (AKI), and traumatic brain injury (TBI). However, these syndromes, while familiar to clinicians, are inherently diverse and encompass various pathophysiological processes that...Read more

2022 25 Jan

An observational, multicohort, retrospective study was conducted to validate two machine-learning clinical classifier models for assigning acute respiratory distress syndrome (ARDS) subphenotypes. Two ARDS subphenotypes with distinct biological and clinical features and differential treatment responses have been identified in seven individual cohorts....Read more

2021 19 Oct

Patients with COVID-19 related ARDS present with distinct respiratory subphenotypes. But most phenotyping schema is limited by sample size, disregard for temporal dynamics and insufficient validation.   In the PRoVENT-COVID study, researchers aimed to identify respiratory subphenotypes of COVID-19-related ARDS. This was an investigator-initiated...Read more