Search Tag: heterogeneity of treatment effect

Sepsis

2025 27 Jan

Over 50 RCTs have examined resuscitation strategies in sepsis, but the optimal approach remains unclear. Early goal-directed therapy (EGDT), a 6-hour protocol involving fluids, vasopressors, inotropes, and blood products, showed a significant reduction in mortality in a landmark trial. However, subsequent larger trials did not replicate these benefits,...Read more

ICU Management

2023 21 Mar

At the #ISICEM23 this week in Brussels, the benefits and harms of therapeutic-dose heparin varied by hospitalised COVID-19 patient characteristics were discussed, and the importance of considering the heterogeneity of treatment effect (HTE) in the design and analysis of randomised clinical trials was highlighted.   To date, RCTs that have tested...Read more