Search Tag: corticosteroids

ICU Management

2024 14 May

  Critical illness-related corticosteroid insufficiency (CIRCI) is commonly seen in criticall ill patients and involves systemic inflammation, hypothalamus–pituitary–adrenal axis dysregulation, altered cortisol metabolism, and tissue glucocorticoid resistance.   A task force of international experts from the Society of Critical Care Medicine...Read more

ICU Management

2024 19 Apr

Decision-making in the ICU is a multifaceted process that involves clinical assessment, collaboration among multidisciplinary teams, ethical considerations, evidence-based practice, communication, and continuous adaptation to evolving clinical scenarios.  Read more


2024 13 Feb

  In a subgroup analysis of the Activated Protein C and Corticosteroids for Human Septic Shock (APROCCHSS) trial, researchers aimed to explore the effects of hydrocortisone plus fludrocortisone on patients with community-acquired pneumonia (CAP) compared to those with non-CAP-related septic shock. The goal was to determine whether glucocorticoids...Read more

ICU Management

2023 06 Dec

ARDS is a life-threatening respiratory failure characterised by acute hypoxaemia and bilateral radiographic infiltrates. The definition of ARDS has evolved over 50 years, with recent suggestions to include intubated and non-intubated patients. Management remains largely supportive, focusing on strategies to limit lung injury, but high mortality rates...Read more

ICU Management

2023 12 Sep

Corticosteroid use in the care of critically ill patients has been the subject of ongoing research with conflicting findings. There is a growing interest in understanding their role in treating a common source of sepsis: community-acquired pneumonia (CAP). Some studies have focused on determining whether corticosteroids provide clinical benefits to...Read more

ICU Management

2021 06 Apr

Pre-existing respiratory disease could worsen the severity of COVID-19. A review of cases has shown that the prevalence of chronic respiratory disease in hospitalised COVID-19 patients was lower compared to prevalence in the general population. Another systematic review found mixed evidence on asthma. Some data suggests hospitalisation was equally...Read more

ICU Management

2020 24 Nov

The use of corticosteroids for respiratory diseases has been a matter of discussion. Here, we present recent evidence of corticosteroids benefits for COVID-19, including improvements in mortality and ventilator-free days. M ore than six months riding treacherous waves in the COVID-19 storm had passed until a glimpse of a rudimentary...Read more

ICU Management

2020 02 Oct

The use of corticosteroids to treat severe infections has been a controversy for quite a long time. Now, as we face the COVID-19 pandemic, clinical research on corticosteroids has received a significant push.   During the first six months of 2020, 55 studies of corticosteroids for the treatment of COVID-19 have been registered. The RECOVERY trial...Read more

ICU Management

2019 01 Dec

Septic shock is a serious illness that is associated with high morbidity and mortality. A significant number of patients who develop septic shock also have a number of comorbidities that further worsens the prognosis. Over the years, many studies have been published on the benefits of corticosteroids in patients with septic shock. Most of these...Read more

ICU Management

2018 13 Aug

There is a significant association between corticosteroid use and intensive care unit-acquired weakness, according to results of a systematic review and meta-analysis. Thus, exposure to corticosteroids should be limited, or the administration time should be shortened in clinical practice to reduce the risk of ICU-acquired weakness in adult patients,...Read more