Search Tag: bleeding
2025 08 Apr
Severe traumatic injuries cause 4.4 million deaths globally each year, with haemorrhage responsible for 35–40% of these deaths, making it the second leading cause after brain injuries. Haemorrhagic deaths occur rapidly, often before hospital arrival, necessitating fast, pre-hospital interventions like haemostatic dressings, tourniquets, hypothermi1Read more
2024 30 Jul
Direct oral anticoagulants (DOACs) like apixaban, edoxaban, rivaroxaban (all FXa inhibitors), and dabigatran (a thrombin inhibitor) have been used for many years, with their generic versions becoming increasingly available. Though DOACs have a lower risk of serious bleeding, such as intracranial haemorrhage, compared to vitamin K antagonists, 1Read more
2024 30 Apr
The impact of trauma on global health is significant, resulting in millions of deaths and disabilities annually, with a particularly high toll on young people. However, the elderly are also increasingly affected. Variances in trauma-related death patterns worldwide are influenced by factors such as prompt treatment availability and the prevale1Read more
2023 07 Mar
According to the Global Burden of Diseases, Injuries, and Risk Factors Study, trauma accounted for 8% of total deaths annually. Among adolescents aged 10-24 years, road injuries, self-harm, and interpersonal violence are the top causes of disability-adjusted life-years, and road injuries are ranked first in the 25-49 year age group. Post-traumatic1Read more
2019 26 Sep
Specific treatment options for factor Xa inhibitor-related bleeding, focusing on drugs like rivaroxaban, apixaban, and edoxaban. Non-vitamin K oral anticoagulants (NOACs/DOACs) are direct reversible inhibitors of factor Xa. These drugs are also reversible inhibitors versus warfarin or other vitamin K antagonist that are used in Europe. 1Read more
2019 02 Apr
An updated guideline on the management of significant bleeding and coagulopathy following major trauma has been released by the pan-European, multidisciplinary Task Force for Advanced Bleeding Care in Trauma. The document, published in the journal Critical Care, includes recommendations intended to guide the management of patients during the early1Read more
2018 01 Jun
Coagulation management remains a formidable challenge in severely bleeding trauma patients. A strong rationale suggests starting treatment of trauma-induced coagulopathy in the pre-hospital phase. The burden of trauma is increasing worldwide, particularly in less well-resourced nations. There are an estimated 5 million deaths per year, mo1Read more
2018 03 Apr
A new study compared outcomes among patients with atrial fibrillation hospitalised for bleeding after starting anticoagulation (warfarin, dabigatran, or rivaroxaban). Results show rivaroxaban and dabigatran were associated with shorter hospitalisations; however, there were no differences in 30- and 90-day mortality. These findings suggest bleeding1Read more
2014 20 Nov
The AABB, formerly the American Association of Blood Banks, has developed a guideline on appropriate use of platelet transfusion in adult patients. The new guideline published in the Annals of Internal Medicine emphasises judicious use of the procedure to reduce patient risk and conserve resources. The guideline was developed following a systema1Read more