Search Tag: antibiotics
2017 28 Nov
Phase III study program with Amikacin Inhale in addition to standard of care in intubated and mechanically ventilated patients with Gram-negative pneumonia does not meet primary endpoint of superiority Bayer announced on 24 November 2017 that INHALE, a global Phase III clinical study program investigating Amikacin Inhale in addition to standard of...Read more
2017 31 May
"Each hour’s delay in initiating antibiotics costs lives" is a doctrine that has attained quasi-religious status. Like most (quasi-)religions this is founded more on faith and hope than hard fact, according to an article in press in the American Journal of Respiratory and Critical Care Medicine. Article author Mervyn Singer, Professor of Intensive...Read more
2017 16 Mar
Multidrug resistance (MDR) is increasing worldwide and has been acknowledged as one of the major threats to healthcare by the World Economic Forum and the World Health Organization (World Health Organization 2014). Intensive care unit (ICU) patients seem to be particularly susceptible for acquiring MDR organisms, either just as colonisers, or as pathogens...Read more
2017 16 Mar
Treating patients with multidrugresistant (MDR) pathogens is an increasing challenge for intensive care unit (ICU) physicians. In the ICU, compared to other hospital departments, severe infections are most prevalent and antimicrobial use is most abundant. Not surprisingly, antimicrobial resistance (AMR) has emerged primarily in the intensive care setting, where...Read more
2017 08 Feb
Philips and Diagnostics Development, a P&M Venge company, evaluate the novel human neutrophil lipocalin (HNL) biomarker for the rapid detection of bacterial infection Based on Philips’ Minicare I-20 handheld diagnostics platform, the Minicare HNL assay is recognized for its potential to provide physicians with 10-minute confirmation of bacterial...Read more
2017 08 Feb
Philips and Diagnostics Development, a P&M Venge company, evaluate the novel human neutrophil lipocalin (HNL) biomarker for the rapid detection of bacterial infection Based on Philips’ Minicare I-20 handheld diagnostics platform, the Minicare HNL assay is recognized for its potential to provide physicians with 10-minute confirmation of bacterial...Read more
2016 08 Nov
Two recent Cochrane reviews have evaluated the evidence on oral hygiene care to prevent ventilator-associated pneumonia (CAP) and antibiotics to treat it. Recommendations can be made on oral hygiene, but insufficient evidence exists for antibiotics. See Also : Seven Days Antibiotics OK for HAP/ VAP, New Guidelines Oral Hygiene In the review...Read more
2016 27 Sep
Recently a number of new antibiotics or combinations for complicated intra-abdominal infections have been introduced. Here we review the currently available data of these new drugs and discuss how they can be used in critically ill patients with complicated intraabdominal infections. Complicated intra-abdominal infections (cIAI) remain...Read more
2016 05 Sep
Procalcitonin (PCT) is increasingly used in health services to diagnose and manage sepsis, and is authorised for use for this purpose in the United States. A recently published study found that patients who had 1-2 PCT evaluations on their first day of admission to the intensive care unit (ICU) had a significantly lower hospital and ICU length of stay,...Read more
2016 19 Jul
New clinical practice guidelines from the Infectious Diseases Society of America (IDSA) and American Thoracic Society (ATS) advise shorter antibiotics courses for hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP) - seven or fewer days of antibiotics, in a change from previous recommendations. The guidelines recommend...Read more
2016 12 Oct
Welcome to 19th APCCCM 2016. The APCCCM will combine with the 2nd Joint Meeting of JSICM & TSCCM together with the 7th Critical Care Conference in Thailand and the TSCCM Annual Meeting 2016, together and stronger. With our experiences in organizing the Critical Care Conferences in Thailand in the past years, we chose Bangkok Convention Centre at CentralWorld...Read more
2016 02 Feb
An interdisciplinary team of researchers at UC San Diego have developed a test to find out if bacteria are susceptible to antibiotics, with results available in just a few hours. They hope that this advance could slow the appearance of drug resistance and allow appropriate treatment for patients with life threatening bacterial infections to be identified...Read more
2016 20 Jan
More precise use of antibiotics may result from a blood test, according to an observational study from scientists at Duke Health, published in Science Translational Medicine . The infectious disease and genomics experts developed ‘gene signatures’, which are patterns that reflect which of a patient’s genes are turned on or off, to indicate whether...Read more
2016 05 Jan
Antibiotic dosing regimens for critically ill patients require constant vigilance, due to extreme shifts on organ function that can impact on drug exposure. In a recent article in Medicina Intensiva Australian researchers Menino Cotta, Jason Roberts and Jeffrey Lipman recommend therapeutic drug monitoring and individualising and tailoring dose for...Read more
2015 07 Dec
The European Congress of Clinical Microbiology and Infectious Diseases , the annual meeting of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) is the most attended infectious disease conference worldwide. This year, more than 10,000 clinicians and scientists attended the congress to present and share the latest research...Read more
2015 07 Dec
ICU Management is pleased to host three reports from the European Congress of Clinical Microbiology and Infectious Diseases, the annual meeting of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID). ECCMID is the most attended infectious disease conference worldwide. More than 10,000 clinicians and scientists attended ECCMID...Read more
2015 24 Nov
New guidelines on the prevention and control of multidrug-resistant Gram-negative bacteria in hospitals have been published by the Journal of Hospital Infection . These guidelines are accredited by the National Institute for Health and Care Excellence in the UK. Gram-negative bacteria (MDRGNB) include common types such as E. coli that are present...Read more
2015 23 Nov
A promising new drug for sepsis will have its first clinical trials thanks to a new grant from the British Heart Foundation . The new drug, called L-257, has been shown to improve survival and reduce organ failure during sepsis in animal models. The BHF Translational Award was granted to Dr. James Leiper and his clinical collaborator Dr. Simon Lambden...Read more
2015 29 Oct
Researchers at the University of Twente (Enschede, Netherlands) have developed an eHealth application that provides support for care providers when administering antibiotics in hospitals. They say this eHealth tool is intended to help improve the quality of work of healthcare professionals that leads to safer patient care. The app was created as part...Read more
2015 12 Oct
Researchers analysed use of seven low-value clinical services in Choosing Wisely campaign and found notable declines in two services: the use of imaging for headaches and cardiac imaging in low risk patients. Their findings are reported in JAMA Internal Medicine . One way to minimise healthcare costs is to reduce the use of unnecessary medical procedures...Read more
2015 15 Sep
Virginia Tech researchers say a new group of antibiotics shows potential in fighting the bacteria Staphylococcus aureus (staph) and the antibiotic-resistant strains commonly known as MRSA. The discovery, published in Medicinal Chemistry Communications , shows that the new antibiotics are unlike contemporary antibiotics because they contain iridium,...Read more
2015 18 Aug
According to Johns Hopkins researchers, patients admitted to an intensive care unit (ICU) for Clostridium difficile infection were at risk for developing subsequent C. difficile infections. Their finding is reported in the journal Infection Control & Hospital Epidemiology . “Importantly in this study, colonisation with toxigenic C. difficile on admission...Read more
2015 21 Jul
Variation in antibiotic prescription is mostly due to the different routines of healthcare providers rather than differences in patient characteristics, practice standards at different hospitals or the clinical setting, according to a study published in the Annals of Internal Medicine. 10 percent of health care providers write an antibiotic prescription...Read more
2015 04 Jun
A new University of Michigan and VA study shows that older adults are three times more likely to develop sepsis — a body-wide catastrophic response to infection — in the first three months after leaving a hospital than at any other time. Notably, the risk of sepsis is 70 percent higher for those who received care that is likely to alter the balance...Read more
2015 21 Apr
Sepsis is a common condition whereby an infection triggers an extreme immune response, resulting in widespread inflammation, blood clotting, and swelling. Although sepsis is believed to contribute to between a third and a half of all hospital deaths, the condition remains poorly understood. Now leading doctors warn that medical and public recognition...Read more