Search Tag: antibiotics

ICU Management

2018 19 Jun

Medical decision-making about antibiotic use in critically ill patients is challenging and complex. The need for antibiotic stewardship requires judicious prescription and choice of antimicrobials, as the need for effective therapy has to be put in balance with the need to limit undue selection pressure, and all this must be done in a context of... Read more

ICU Management

Results of antimicrobial stewardship programme implementation in multidisciplinary hospital

2018 01 Jun

The interventional single-centre with historical control study was conducted in a 600-bed multidisciplinary hospital to evaluate 4 years’ results of an antimicrobial stewardship programme. We found a significant reduction in average duration of courses of antimicrobial therapy, length of stay of patients with infection in ICU, mortality in patients... Read more

ICU Management

2018 26 Mar

The Surviving Sepsis Campaign recommends starting empiric broad-spectrum antibiotics in the initial management of patients with severe sepsis and septic shock (Rhodes et al. 2017). As a consequence, many patients receive unnecessary antibiotics, exposing them to adverse events, while others might be undertreated in spite of broad-spectrum therapy... Read more

ICU Management

New way to fight sepsis: rev up patients' immune systems

2018 13 Mar

People especially those with critical illness develop sepsis when an infection triggers an overwhelming immune response, ultimately wreaking havoc on the immune system. Traditional approaches to sepsis therapy do not address the critical problem of patients' severely compromised immune systems. Now, a clinical trial demonstrates that a drug that revs... Read more

ICU Management

2017 07 Dec

As I usually do when I'm writing, first I'll throw a random fact--not so random--with a slight relation with our subject. The thing is, I lack good metaphors. Some time ago I stumbled on a fantastic article by Holloway discussing a new approach to treating multi-drug-resistant tuberculosis . The climax is: in Switzerland, England and New York, tuberculosis-related... Read more

ICU Management

Phase III study program with Amikacin Inhale in patients with Gram-negative pneumonia results

2017 28 Nov

Phase III study program with Amikacin Inhale in addition to standard of care in intubated and mechanically ventilated patients with Gram-negative pneumonia does not meet primary endpoint of superiority Bayer announced on 24 November 2017 that INHALE, a global Phase III clinical study program investigating Amikacin Inhale in addition to standard of... Read more

ICU Management

Antibiotics for Sepsis - Does Each Hour Really Count?

2017 31 May

"Each hour’s delay in initiating antibiotics costs lives" is a doctrine that has attained quasi-religious status. Like most (quasi-)religions this is founded more on faith and hope than hard fact, according to an article in press in the American Journal of Respiratory and Critical Care Medicine. Article author Mervyn Singer, Professor of Intensive... Read more

ICU Management

Volume 17 - Issue 1, 2017

2017 16 Mar

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ICU Management

Antibiotic Resistance in the ICU: Time to Take Things Seriously!

2017 16 Mar

  Multidrug resistance (MDR) is increasing worldwide and has been acknowledged as one of the major threats to healthcare by the World Economic Forum and the World Health Organization (World Health Organization 2014). Intensive care unit (ICU) patients seem to be particularly susceptible for acquiring MDR organisms, either just as colonisers, or as pathogens... Read more

ICU Management

Antimicrobial Stewardship in the ICU

2017 16 Mar

Treating patients with multidrugresistant (MDR) pathogens is an increasing challenge for intensive care unit (ICU) physicians. In the ICU, compared to other hospital departments, severe infections are most prevalent and antimicrobial use is most abundant. Not surprisingly, antimicrobial resistance (AMR) has emerged primarily in the intensive care setting, where... Read more