Search Tag: antibiotics

The Alphabet Book of Sepsis

2022 16 Mar

In this article, the author provides the alphabet review of sepsis and septic shock based on personal clinical experience and choice. Sepsis and septic shock have been defined in 2016 (Singer et al. 2016) and the management of patients is framed by the Surviving Sepsis Campaign guidelines with its renewed version in 2021 (Evans et al. 2021).... Read more

Why is the Pharmaceutical Industry Not Developing New Antibiotics?

2021 26 Nov

An overview of antibiotic resistance, causative factors, reasons for the lack of research and drug development in this area and potential solutions. Key Points Antibiotic resistance is one of the biggest threats to global health. The  primary  culprit of fuelling antibiotic resistance is the misuse and overuse of existing antibiotic... Read more

Efficacy, Appropriateness of Antibiotic Use in the ICU

2021 09 Nov

The frequency of antibiotic-resistant pathogens continues to increase, resulting in higher community-acquired infections and high mortality rates in critically ill patients.   In this review, the researchers critically appraise available evidence through a comprehensive literature review to investigate effective empiric antibiotic administration... Read more

Antibiotic Delay Intervals, Mortality Among Patients With Suspected Sepsis

2021 27 Apr

Timely delivery of antibiotics is a major cornerstone of sepsis therapy. Clinical evidence suggests that every one-hour delay in antibiotics after emergency department (ED) triage or the onset of organ dysfunction or shock could result in a 3-7% increase in the odds of a poor outcome. The Surviving Sepsis Campaign (SSC) guidelines recommend antibiotic... Read more

Biomarker-Guided Antibiotic Stewardship in Suspected Ventilator-Associated Pneumonia

2019 15 Dec

Ventilator-associated pneumonia carries enormous morbidity and mortality, including prolonging hospital stay and increasing the cost of healthcare. In most cases, ventilator-associated pneumonia occurs without any specific signs or symptoms. Making an accurate diagnosis is often difficult. Unlike the past, the administration of empirical antibiotics... Read more

Procalcitonin-Guided Antibiotic Therapy in Severely Critically Ill Patients

2019 30 Aug

The controversy surrounding the efficacy of the blood infection biomarker, procalcitonin (PCT), for guidance in acute infections and sepsis treatment remains. PCT is a calcitonin precursor produced by epithelial cells when infected with bacteria and has been identified as a marker due to the protein levels’ variation upon infection initiation and cessation.... Read more

Antibiotic timing and administration in the ED

2019 01 May

Antibiotics are often prescribed in the emergency department (ED) to patients with suspected infection before any definitive diagnosis can be made. However, amidst increasing antibiotic resistance, their use should be limited to those at high risk of infection or further clinical deterioration. Current tools to aid clinical decision-making include... Read more

Optimising beta-lactam treatment in the ICU - expert consensus

2019 03 Apr

The French Society of Pharmacology and Therapeutics (SFPT) and the French Society of Anaesthesia and Intensive Care Medicine (SFAR) have released guidelines on the optimisation of beta-lactam treatment in intensive care unit (ICU) patients. The two groups strongly recommend the use of personalised dosing, continuous or prolonged infusion and therapeutic... Read more