Search Tag: antibiotics

ICU Management

Biomarkers in Sepsis

2023 13 Mar

This article describes the application of existing and emerging biomarkers in the diagnosis and management of sepsis and pneumonia. Introduction: The Need for  Biomarkers  in Sepsis Sepsis is defined as a dysregulated host response to infection that results in life threatening organ dysfunction. It carries an estimated... Read more


AMR Dilemma: To Give or Not to Give Antibiotics

2022 24 Nov

The two primary reasons for using antibiotics are treating and preventing bacterial infections. However, a leading cause of the overuse of antibiotics is the misdiagnosis of sepsis. Early and accurate diagnostics using point-of-care biomarkers can help address this issue.  Sepsis is a dysregulated reaction of the body to infection. It is a significant... Read more

ICU Management

Antibiotic Stewardship in Critical and Emergency Care

2022 14 Oct

An overview of antimicrobial stewardship in critical care units and emergency departments, highlighting aspects to reduce multidrug resistance focusing on antibiotic optimisation in respiratory infections and sepsis. Introduction Infections caused by resistant bacteria are associated with higher treatment costs and increased morbidity... Read more

ICU Management

Multidrug-Resistant Gram-Negative Bacteria in the ICU

2022 14 Oct

Severe infections by antibiotic resistant gram-negative bacteria are frequent in ICU patients. They are associated with high morbidity and mortality. Introduction Bacterial infections in patients hospitalised in the Intensive Care Unit (ICU) are frequent, and they elicit an increase in morbidity and mortality. The emerging development... Read more

ICU Management

Rapid Diagnostics and Antimicrobial Resistance in the ICU

2022 14 Oct

The need to address the problem of antimicrobial resistance, the importance of faster diagnosis of bacterial infections and an overview of rapid diagnostic testing. Antimicrobial resistance (AMR) is rapidly increasing on a global scale. The discovery of penicillin revolutionised the field of medicine, providing safe harbour from the most... Read more

ICU Management

Sepsis in Critical Care

2022 14 Oct

The importance of clearly defining sepsis, improving early recognition strategy, and increasing the understanding of innate and adaptive immune system derangements that facilitate the development of sepsis. The improvement in mortality outcomes of patients with sepsis is attributable to the early recognition of sepsis, better adherence to guidelines,... Read more

ICU Management

The Alphabet Book of Sepsis

2022 16 Mar

In this article, the author provides the alphabet review of sepsis and septic shock based on personal clinical experience and choice. Sepsis and septic shock have been defined in 2016 (Singer et al. 2016) and the management of patients is framed by the Surviving Sepsis Campaign guidelines with its renewed version in 2021 (Evans et al. 2021).... Read more

Executive Health Management

Why is the Pharmaceutical Industry Not Developing New Antibiotics?

2021 26 Nov

An overview of antibiotic resistance, causative factors, reasons for the lack of research and drug development in this area and potential solutions. Key Points Antibiotic resistance is one of the biggest threats to global health. The  primary  culprit of fuelling antibiotic resistance is the misuse and overuse of existing antibiotic... Read more

ICU Management

Efficacy, Appropriateness of Antibiotic Use in the ICU

2021 09 Nov

The frequency of antibiotic-resistant pathogens continues to increase, resulting in higher community-acquired infections and high mortality rates in critically ill patients.   In this review, the researchers critically appraise available evidence through a comprehensive literature review to investigate effective empiric antibiotic administration... Read more

ICU Management

Antibiotic Delay Intervals, Mortality Among Patients With Suspected Sepsis

2021 27 Apr

Timely delivery of antibiotics is a major cornerstone of sepsis therapy. Clinical evidence suggests that every one-hour delay in antibiotics after emergency department (ED) triage or the onset of organ dysfunction or shock could result in a 3-7% increase in the odds of a poor outcome. The Surviving Sepsis Campaign (SSC) guidelines recommend antibiotic... Read more