Search Tag: acute respiratory distress syndrome
Dramatic-decline-in-ards-mortality-rates
2014 23 Oct
According to the largest study to date of mortality trends in patients with acute respiratory distress syndrome (ARDS), advances in critical care medicine played a major role in reducing the rate of mortality over a sixteen year period. The study has been published in the journal CHEST and will be presented at Chest 2014, the annual meeting of the...Read more
Ards-still-under-recognised-under-treated-lung-safe-results
2016 22 Feb
Acute respiratory distress syndrome (ARDs) seems to be under-recognised, under-treated and associated with a high risk of mortality, despite the ARDS Berlin definition and good evidence on treatments. The results of the ESICM LUNG-SAFE observational study are published in JAMA. Speaking to ICU Management, John G. Laffey , MD, MA, of the Departments...Read more
Extracorporeal-membrane-oxygenation-for-immunocompromised-patients-with-ards
2016 11 Mar
Improved Outcomes of Immunocompromised Patients Admitted to the ICU Immunocompromised patients, who include patients with haematological malignancies (HMs), solid tumours, solid-organ transplants, human immunodeficiency virus (HIV) or long-term corticosteroid use, are increasingly admitted to intensive care units (ICUs). Their survival has improved...Read more
Ards-still-under-recognised-under-treated
2016 11 Mar
Acute respiratory distress syndrome (ARDS) seems to be underrecognised, under-treated and associated with a high risk of mortality, according to the results of the ESICM LUNG-SAFE observational study, published in JAMA . Speaking to ICU Management & Practice, John G. Laffey , MD, MA, of the Departments of Anesthesia and Critical Care Medicine,...Read more
Cochrane-high-frequency-oscillatory-ventilation-not-supported-for-ards
2016 19 Apr
High-frequency oscillation ventilation does not reduce hospital and 30-day mortality in acute respiratory distress patients, compared to conventional mechanical ventilation. These are the findings of the 2016 updated Cochrane Systematic Review. The systematic review, by Sachin Sud, Trillium Health Center, University of Toronto, Division of Critical...Read more
Young-females-at-high-risk-for-psych-symptoms-after-ards
2016 26 Apr
Young, female ARDS survivors, who were unemployed prior to ICU admission, are at greatest risk of psychiatric symptoms following discharge. And it is not the sickest patients with the longest ICU stay who are most at risk, according to the results from a multicentre national U.S. study, led by Johns Hopkins University researchers and published in Critical...Read more
Ards-prevalence-in-lung-safe-study-questioned
2016 03 May
The recent publication of the results from the Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG SAFE) study has prompted a rejoinder from Jesús Villar, CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Spain and colleagues Marcus J. Schultz and Robert M. Kacmarek, writing in Critical...Read more
Helmet-based-ventilation-had-better-results-than-facemask-for-ards-patients
2016 17 May
Results of a trial of helmet-based ventilation have shown that using a transparent air-tight helmet instead of a facemask helped critically ill patients breathe better and reduced their need for mechanical ventilation. In the trial, patients who were treated with helmet ventilation spent less time in the intensive care unit and lower mortality. The...Read more
Study-microbiome-disruption-may-have-key-role-in-ards-sepsis
2016 18 Jul
Researchers from the University of Michigan (U-M) Medical School have found culture-independent evidence that the lung microbiome is enriched with gut bacteria, both in a murine model of sepsis and in patients with ARDS. In more severely critically ill patients, lung bacteria were more outnumbered by the misplaced gut bacteria. The researchers conclude...Read more
Study-ards-costs-survival-qol-over-one-year
2016 24 Aug
Patients who survive acute respiratory distress syndrome experience low quality of life at one year after intensive care unit (ICU) admission, and experience high associated post-hospital healthcare costs, out of pocket expenses and lost earnings. Joachim Marti, Centre for Health Policy, Imperial College London, UK, and colleagues from the UK and...Read more
Ards-and-precision-medicine
2017 16 Mar
What is the path forward for treatment of acute respiratory distress syndrome (ARDS)? Is it big trials (favoured by clinical scientists) or further insight into disease physiopathology (favoured by basic scientists)? Or both? Funding resources are limited and the debate is wide open. In the post-genomic era, a new direction is needed. On 20 January 2015,...Read more
Economic-cost-to-surviving-ards-new-study
2017 28 Apr
Research published today in the American Journal of Respiratory and Critical Care Medicine sheds light on the economic toll on survivors of acute respiratory distress syndrome. Nearly fifty percent of survivors who worked before they were ill were not working after a year, and lost nearly two-thirds of their annual income. The researchers estimated...Read more
Ards-treat-high-volume-lower-mortality
2017 22 May
Analysis of data from the large French CUB-REA database indicates that mortality from acute respiratory distress syndrome (ARDS) was lower in high-volume ICUs than low and moderate volume ICUs. Notably, between 2000 and 2014, among 35 ICUs in the CUB-REA registry, ICU mortality decreased despite an increase in ARDS severity. The findings were presented...Read more
Clinical-trials-in-ards-challenges-and-opportunities
2017 07 Jun
A number of supportive therapies have reduced mortality in acute respiratory distress syndrome (ARDS), including lung-protective mechanical ventilation, neuromuscular blockade, and prone positioning. Fluid-conservative therapy has also increased ventilator-free days in patients with ARDS. However, the lack of success of pharmacological therapies...Read more
Respiratory-support-in-ards-an-expert-opinion
2017 19 Sep
Acute respiratory distress syndrome (ARDS) is a common condition in intensive care unit patients and remains a major concern, with mortality rates of around 30-45% and considerable long-term morbidity. In an opinion document published in the journal Critical Care, international experts review the available clinical evidence related to ventilator support...Read more
Driving-pressure-and-hospital-mortality-in-non-ards-patients
2017 24 Oct
According to researchers in Canada, driving pressure was not associated with hospital mortality in a cohort of mechanically ventilated, critically ill patients without Acute Respiratory Distress Syndrome (ARDS), in whom compliance was also not associated with mortality. They say their findings published in the journal CHEST need to be replicated in...Read more
After-50-years-ards-stuck-in-the-past
2017 14 Nov
The acute respiratory distress syndrome (ARDS) was first reported in 1967. Upon the occasion of its 50th birthday, ARDS is due for a midlife crisis, says Dr. Robert P. Dickson, of the Division of Pulmonary and Critical Care Medicine, University of Michigan Health System. "In our era of molecular medicine, ARDS seems a bit stuck in the past," he writes...Read more
Can-we-improve-the-reliability-of-ards-diagnosis
2018 08 Jan
Failure to reliably diagnose ARDS, or acute respiratory distress syndrome, could lead to underrecognition and undertreatment in clinical practice. New research shows the reliability of the Berlin ARDS definition is "moderate," driven primarily by differences in chest imaging interpretation. The study is in press in the journal CHEST. The 2012 revision...Read more
Making-mechanical-ventilation-safe-for-ards
2018 08 Jan
The acute respiratory distress (ARDS) lung is usually characterised by a high degree of inhomogeneity. Indeed, the same lung may show a wide spectrum of aeration alterations, ranging from completely gasless regions, up to hyperinflated areas, explain Luciano Gattinoni, Tommaso Tonetti and Michael Quintel in an article published in the journal Critical...Read more
Ards-delirium-and-antipsychotic-use-reviewed
2018 21 Feb
Acute respiratory distress syndrome (ARDS) often requires prolonged and complicated hospital courses putting patients at risk for intensive care unit (ICU) delirium. Antipsychotics are prescribed to decrease the severity and duration of ICU delirium; however, these drugs are associated with many adverse effects including respiratory failure. "Given...Read more
Co2-in-the-critically-ill
2018 16 Mar
CO 2 exerts potent effects on lung biology that could be clinically relevant in critically ill patients, in particular those with acute respiratory distress syndrome (ARDS). The impact of hypercapnia on outcome in these patients is yet to be determined. The physiological effects of hypercapnia are increasingly well understood, but the literature...Read more
Ards-reclassification-the-debate-continues
2018 15 May
A new analysis of data from patients enrolled in high-quality ARDSnet trials showed no difference between patients with moderate-severe and mild-moderate ARDS in terms of mortality, even though there were differences in rapid resolution of ARDS, ventilator-free days and ICU-free days. The research is published online in Annals of the American Thoracic...Read more
Study-air-pollution-associated-with-ards-hospitalisation-in-over-65s
2018 01 Jun
A comparison of hospital admissions of patients over 65 and air pollution in the USA has found an association between exposure to pollutants and admission for acute respiratory distress syndrome (ARDS). The study was presented at the annual meeting of the American Thoracic Society. The researchers analysed data by zip code from nearly 30 million...Read more
Alleviating-inflammation-new-inhibitor-could-treat-ards-in-future
2018 20 Nov
A newly discovered OGG1 inhibitor has been found to decrease lung inflammation in mice and could in future treat acute respiratory distress syndrome (ARDS), sepsis and autoimmune diseases. The six-year study, by an international team of researchers, is published in Science . The research shows that the OGG1 protein, which is involved in repairing...Read more
Closer-monitoring-needed-for-patients-with-mild-ards
2018 04 Dec
If you landed here from ICU Highlights e-newsletter you may be looking for New protocol for respiratory infectious disease diagnosis in ICU. Hospital mortality in acute respiratory distress syndrome (ARDS) is approximately 40 percent, but mortality and trajectory in “mild” ARDS – classified only since 2012 – are unknown. A new study finds that...Read more
Are-sniffer-systems-effective-in-detecting-ards
2018 11 Dec
Acute respiratory distress syndrome (ARDS) results in substantial mortality but remains underdiagnosed in clinical practice. For this reason, automated “sniffer” systems that analyse electronic records have been developed to assist clinicians with ARDS diagnosis. However, a new systematic review found that these sniffer tools had moderate to high predictive...Read more