Search Tag: acute respiratory distress syndrome
2024 23 Sep
Optimal fluid management in patients with acute respiratory distress syndrome (ARDS) poses significant challenges. A positive fluid balance is linked to extended mechanical ventilation, longer ICU stays, and increased mortality due to increased pulmonary capillary pressure, which exacerbates inflammation and causes alveolar flooding. On the other hand,...Read more
2024 09 Sep
In patients with severe acute respiratory distress syndrome (ARDS), managing gas exchange and avoiding ventilation-induced lung injury (VILI) are key challenges. Venovenous extracorporeal membrane oxygenation (ECMO) is used for severe ARDS with persistent hypoxaemia, effectively improving gas exchange and reducing ventilation pressures, though...Read more
2024 09 Apr
The heterogeneity of acute respiratory distress syndrome (ARDS) has played a role in hindering successful pharmacotherapy in clinical trials. To address this, researchers have identified two molecular phenotypes of ARDS - hypoinflammatory and hyperinflammatory - through latent class analysis (LCA) applied to protein biomarkers and clinical data...Read more
2023 06 Dec
The effectiveness of prone positioning to improve outcomes in patients with severe acute respiratory distress syndrome (ARDS) undergoing venovenous extracorporeal membrane oxygenation (VV-ECMO) compared to supine positioning is unknown. The PRONECMO multicenter randomised clinical trial aimed to address the lack of robust evidence regarding prone...Read more
2023 08 Nov
Acute Respiratory Distress Syndrome (ARDS) has been known for over a century but was officially described in 1967. Despite revisions in its definition, there's ongoing debate about whether ARDS is a distinct medical condition. The current diagnostic criteria for ARDS are challenging to apply in clinical practice, so standardising the assessment of...Read more
2023 15 Feb
Prone positioning is a medical intervention that was initially proposed over 50 years ago as a way to improve gas exchange. Multiple clinical trials have been conducted on its effectiveness, with the Proning Severe ARDS Patients landmark trial demonstrating a mortality benefit in patients with severe ARDS. As a result, expert consensus and societal...Read more
2023 15 Feb
There is increasing evidence supporting the use of extracorporeal membrane oxygenation (ECMO) for severe acute respiratory distress syndrome (ARDS) in patients that do not respond to maximal medical therapy. ARDS can occur in some COVID-19 patients who are hospitalised, and ECMO can be utilised as a treatment option in some cases. Using ECMO can help...Read more
2022 28 Apr
Speakers Thomas Metkus, MD Divisions of Cardiology and Cardiac Surgery, Departments of Medicine and Surgery Johns Hopkins University School of Medicine Dennis Begos, MD, FACS, FACRS Medical Director, Medical and Scientific Affairs...Read more
2021 14 Sep
Acute respiratory distress syndrome (ARDS) occurs in approximately 40% of patients with severe acute brain injury (sABI), including acute ischaemic stroke, subarachnoid haemorrhage, intracerebral haemorrhage and traumatic brain injury. It is also a major determinant of morbidity and mortality. With the increase in ARDS cases and reports of neurological...Read more
2021 25 Jan
Mechanical ventilation in the ICU for 48 hours or longer is known to be associated with ARDS, which could be present either when ventilatory support is initiated or develop afterwards, typically during the first five days. ARDS affects approximately 23% of mechanically ventilated, critically ill patients and has a mortality of nearly 46%. Patients...Read more
2020 23 Apr
AMOMED Pharma develops medicinal products for patients suffering from septic shock at the intensive care units. Septic shock is a life-threatening complication in COVID-19 patients. Most COVID-19 admissions to the intensive care unit are due to severe lung disorders requiring invasive mechanical ventilation; many with acute respiratory distress...Read more
2019 16 Dec
Acute respiratory distress syndrome (ARDS) is an inflammatory process that could lead to diffuse oedema and hypoxaemic respiratory failure. It is also characterised by increased pulmonary vascular permeability, increased lung weight, and loss of aerated lung. In low and middle-income countries, ARDS mortality ranges from 26 to 58%. A large majority...Read more
2019 22 Nov
Acute respiratory distress syndrome (ARDS) is a serious disorder that causes severe hypoxia requiring mechanical ventilation. It affects approximately 200,000 patients in the US each year, accounting for 10% of ICU admissions and a mortality risk of 25-40%. In many cases, patients also develop dysfunction of other organs that leads to high morbidity...Read more
2019 06 Sep
A recent study assessed the ability of early noninvasive ventilation (NIV) intervention to decrease the need for invasive ventilation in patients with mild forms of acute respiratory distress syndrome (ARDS). This method has already proved successful for acute respiratory failure patients but has not been tested in ARDS. Use of NIV in ARDS patients...Read more
2019 30 Aug
Acute Respiratory Distress Syndrome (ARDS) affects up to 10% of patients in the ICU. Typical symptoms of ARDS include an increase in lung weight and a reduction of aerated lung tissue. For the treatment of ARDS alveolar recruitment is key, however, this has not yet been shown to benefit severe ARDS cases. It has been suggested that lung recruitment...Read more
2019 18 Aug
The effectiveness of personalised mechanical ventilation in patients with acute respiratory distress syndrome (ARDS) is still unclear. A new study was conducted in France to test whether a mechanical ventilation strategy personalised to an individual patient's lung morphology could improve survival compared with the standard of care. For the...Read more
2019 25 Jul
Diagnosis of the Influenza virus remains a challenge in the ICU. It is vital that knowledge of its pathophysiology and epidemiology is known so clinicians can make informed decisions regarding their patients’ health. The Influenza virus is found most commonly to replicate in the respiratory tract in humans. This is mainly due to the haemagglutinin...Read more
2019 30 May
Interview with Rolf Rossaint, Prof. of Anaesthesiology, RWTH University Aachen, Germany. Rolf Rossaint is a Professor and Chairman of the Department of Anaesthesiology of the University Hospital at the RWTH University Aachen, Germany. Prof. Rossaint has published several high-quality studies dealing with the treatment of severe acute respiratory...Read more
2019 05 Mar
There have been multiple advances in the management of acute respiratory distress syndrome (ARDS), but the temporal trends in ARDS-related mortality are not well known. Conservative fluid management strategy for ARDS, in particular, has been extensively studied and is increasingly being used in clinical practice. However, it is largely unknown whether...Read more
2018 11 Dec
The consensus definitions of acute respiratory distress syndrome (ARDS) mainly rely on feasible clinical criteria, which help to group patients together for inclusion in clinical trials and for clinical management. This generates clinical and biological differences in observable patient characteristics. These differences could be used to group ARDS...Read more
2018 11 Dec
Acute respiratory distress syndrome (ARDS) results in substantial mortality but remains underdiagnosed in clinical practice. For this reason, automated “sniffer” systems that analyse electronic records have been developed to assist clinicians with ARDS diagnosis. However, a new systematic review found that these sniffer tools had moderate to high predictive...Read more
2018 04 Dec
If you landed here from ICU Highlights e-newsletter you may be looking for New protocol for respiratory infectious disease diagnosis in ICU. Hospital mortality in acute respiratory distress syndrome (ARDS) is approximately 40 percent, but mortality and trajectory in “mild” ARDS – classified only since 2012 – are unknown. A new study finds that...Read more
2018 20 Nov
A newly discovered OGG1 inhibitor has been found to decrease lung inflammation in mice and could in future treat acute respiratory distress syndrome (ARDS), sepsis and autoimmune diseases. The six-year study, by an international team of researchers, is published in Science . The research shows that the OGG1 protein, which is involved in repairing...Read more
2018 01 Jun
A comparison of hospital admissions of patients over 65 and air pollution in the USA has found an association between exposure to pollutants and admission for acute respiratory distress syndrome (ARDS). The study was presented at the annual meeting of the American Thoracic Society. The researchers analysed data by zip code from nearly 30 million...Read more
2018 15 May
A new analysis of data from patients enrolled in high-quality ARDSnet trials showed no difference between patients with moderate-severe and mild-moderate ARDS in terms of mortality, even though there were differences in rapid resolution of ARDS, ventilator-free days and ICU-free days. The research is published online in Annals of the American Thoracic...Read more
2018 16 Mar
CO 2 exerts potent effects on lung biology that could be clinically relevant in critically ill patients, in particular those with acute respiratory distress syndrome (ARDS). The impact of hypercapnia on outcome in these patients is yet to be determined. The physiological effects of hypercapnia are increasingly well understood, but the literature...Read more
2018 21 Feb
Acute respiratory distress syndrome (ARDS) often requires prolonged and complicated hospital courses putting patients at risk for intensive care unit (ICU) delirium. Antipsychotics are prescribed to decrease the severity and duration of ICU delirium; however, these drugs are associated with many adverse effects including respiratory failure. "Given...Read more
2018 08 Jan
The acute respiratory distress (ARDS) lung is usually characterised by a high degree of inhomogeneity. Indeed, the same lung may show a wide spectrum of aeration alterations, ranging from completely gasless regions, up to hyperinflated areas, explain Luciano Gattinoni, Tommaso Tonetti and Michael Quintel in an article published in the journal Critical...Read more
2018 08 Jan
Failure to reliably diagnose ARDS, or acute respiratory distress syndrome, could lead to underrecognition and undertreatment in clinical practice. New research shows the reliability of the Berlin ARDS definition is "moderate," driven primarily by differences in chest imaging interpretation. The study is in press in the journal CHEST. The 2012 revision...Read more