Search Tag: Vitamin C


2023 07 Mar

Sepsis is associated with long-term cognitive impairment and poor psychological and functional outcomes. Potential mechanisms for this include intracerebral oxidative stress and inflammation. However, there is limited knowledge about the effects of early antioxidant and anti-inflammatory therapy on cognitive, psychological, and functional outcomes...Read more

ICU Management

2022 01 Feb

Sepsis is a life threatening condition with an estimated 49 million cases worldwide and 11 million deaths. It involves organ dysfunction due to a dysregulated host response to infection. Sepsis continues to be a global health issue and is is responsible for approximately 20% of annual global deaths.   Sepsis is typically managed through intravenous...Read more

ICU Management

2020 22 Jan

Sepsis is a life-threatening condition that causes nearly one-third to half of all hospital deaths. It is also responsible for more than 5 million deaths worldwide each year. Patients with septic shock are an important subgroup of sepsis. These patients have circulatory and metabolic abnormalities that further increase their mortality risk. New treatments...Read more

ICU Management

2019 04 Oct

Dr. Alpha A. Fowler of Virginia Commonwealth University presented findings from the CITRIS-ALI trial that studied the role of vitamin C in patients with septic ARDS. The findings were presented @ESICM in Berlin and have just been published in JAMA.  The CITRIS-ALI randomised trial addressed the use of high dose intravenous vitamin C to study...Read more

ICU Management

2020 24 Apr


ICU Management

2019 09 Jul

The combination of intravenous vitamin C, corticosteroids and thiamine has been made famous by Dr. Paul Marik, M.D. for the treatment of sepsis in critically ill patients. The ‘Marik protocol’, also termed HAT (Hydrocortisone, Ascorbic acid, Thiamine), has however come under criticism regarding the lack of evidence. Dr. Marik of Sentara Norfolk...Read more

ICU Management

2018 17 Oct

A new meta-analysis reveals a positive correlation between incorporating vitamin C in the treatment of sepsis and favourable patient outcomes. Results of the meta-analysis showed a marked reduction in mortality and duration of vasopressor administration in the group with the use of vitamin C, despite varying degrees of statistical significance between...Read more

ICU Management

2017 17 Apr

A new study reported in the journal CHEST demonstrates the beneficial effects of high-dose intravenous vitamin C in reducing mortality in patients with severe sepsis. However, an Editorial published in the same issue of CHEST, calls for more studies to determine optimal dose of vitamin C in the critically ill population. See Also : Albumin Administration...Read more

Cardiology Management

2015 12 Jul

According to new research from the University of Copenhagen and Herlev and Gentofte Hospital, high concentrations of vitamin C in the blood from the intake of fruit and vegetables are associated with a reduced risk of cardiovascular disease and early death. The study has been published in the  American Journal of Clinical Nutrition. It is a well-known...Read more