Search Tag: Thiamine

Sepsis

Antioxidant-anti-inflammatory-therapy-in-sepsis

2023 07 Mar

Sepsis is associated with long-term cognitive impairment and poor psychological and functional outcomes. Potential mechanisms for this include intracerebral oxidative stress and inflammation. However, there is limited knowledge about the effects of early antioxidant and anti-inflammatory therapy on cognitive, psychological, and functional outcomes...Read more

ICU Management

Vitamins-trial-no-significant-benefit-of-vitamin-c-cocktail

2020 22 Jan

Sepsis is a life-threatening condition that causes nearly one-third to half of all hospital deaths. It is also responsible for more than 5 million deaths worldwide each year. Patients with septic shock are an important subgroup of sepsis. These patients have circulatory and metabolic abnormalities that further increase their mortality risk. New treatments...Read more

ICU Management

Vitamin-c-drug-cocktail-for-sepsis

2019 09 Jul

The combination of intravenous vitamin C, corticosteroids and thiamine has been made famous by Dr. Paul Marik, M.D. for the treatment of sepsis in critically ill patients. The ‘Marik protocol’, also termed HAT (Hydrocortisone, Ascorbic acid, Thiamine), has however come under criticism regarding the lack of evidence. Dr. Marik of Sentara Norfolk...Read more