Search Tag: PCT

ICU Management

Procalcitonin-Guided Antibiotic Therapy in Severely Critically Ill Patients

2019 30 Aug

The controversy surrounding the efficacy of the blood infection biomarker, procalcitonin (PCT), for guidance in acute infections and sepsis treatment remains. PCT is a calcitonin precursor produced by epithelial cells when infected with bacteria and has been identified as a marker due to the protein levels’ variation upon infection initiation and cessation.... Read more

ICU Management

How effective is procalcitonin-guided antibiotic therapy?

2018 06 Feb

Using biomarkers as a guide to tailor the duration of antibiotic treatment in respiratory infections is an attractive hypothesis assessed in several studies. However, after more than a decade of randomised controlled trials on procalcitonin (PCT)-guided antibiotic treatment, the evidence favouring PCT use is still less than compelling due to limitations... Read more