Search Tag: PCT

ICU Management

PCT-guided Antibiotic Stewardship in COVID-19 Patients

2020 14 Sep

Professor Michael Mansour is a physician-scientist with a research concentration in immune responses against invading pathogens. He attends on the Clinical Transplant Infectious Diseases and Immunocompromised Host Service at the Massachusetts General Hospital - Division of Infectious Diseases, where he cares for solid and stem cell transplant recipients... Read more

Health Management

B·R·A·H·M·S PCT: A Valuable Tool for Bacterial Coinfection Risk Assessment

2020 23 Jun

Procalcitonin – A Critical Biomarker Procalcitonin (PCT) is a member of the calcitonin family and known as a critical biomarker for bacterial infections. To be effective a biomarker must have high diagnostic accuracy and allow early and rapid diagnosis. PCT fulfills these requirements and has already demonstrated superior diagnostic accuracy compared... Read more

ICU Management

Reappraisal of Biomarkers in Sepsis Management

2020 13 Jun

Sepsis biomarkers have an important role in the diagnosis, prognosis, and treatment of sepsis management. If timely and accurate information about biomarkers becomes available, the physician can not only make better therapeutic choices but also monitor the efficacy of the intervention in progress and adjust it accordingly.  In a previous review... Read more

ICU Management

Procalcitonin-Guided Antibiotic Therapy in Severely Critically Ill Patients

2019 30 Aug

The controversy surrounding the efficacy of the blood infection biomarker, procalcitonin (PCT), for guidance in acute infections and sepsis treatment remains. PCT is a calcitonin precursor produced by epithelial cells when infected with bacteria and has been identified as a marker due to the protein levels’ variation upon infection initiation and cessation.... Read more

ICU Management

How effective is procalcitonin-guided antibiotic therapy?

2018 06 Feb

Using biomarkers as a guide to tailor the duration of antibiotic treatment in respiratory infections is an attractive hypothesis assessed in several studies. However, after more than a decade of randomised controlled trials on procalcitonin (PCT)-guided antibiotic treatment, the evidence favouring PCT use is still less than compelling due to limitations... Read more